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Biomedical subjects

K Jonderko

Publications and source records attributed to K Jonderko.

At least 73 records · Page 4Linked to original sources
PubMed1987

Cigarette smoking delays gastric emptying of a radiolabelled solid food in healthy smokers.

The effect of cigarette smoking on gastric emptying was studied in 18 healthy volunteers by means of an isotopic method. Although the observed individual reactions were fairly variable, cigarette smoking significantly delayed gastric emptying of a solid meal. Potential mechanisms of action of cigarette smoking on gastric emptying are discussed, including the role of nicotine. The method of gastric emptying measurement was shown to be reproducible in the paired studies performed in 11 subjects.

Adult↗
PubMed1987

Effect of cigarette smoking on gastric emptying in patients with an active duodenal ulcer.

The effect of cigarette smoking on gastric emptying (GE) of a radiolabelled solid meal was examined in 14 patients with an active duodenal ulcer. The patients underwent GE measurement thrice: under basal conditions and for two smoking sessions, without and after cimetidine pretreatment (2 X 400 mg orally for 2 days and 400 mg orally 1.5 h before the isotropic GE examination) in random order. Cigarette smoking significantly delayed GE (p less than 0.05 for both the gastric half emptying time (H) and the mean transit time (MTT90)). The inhibitory effect of smoking on GE was enhanced after cimetidine pretreatment (p less than 0.02 for H and p less than 0.004 for MTT90, respectively). Potential mechanisms and pathophysiological meaning of the findings are discussed.

Adult↗
PubMed1987

Radionuclide studies on gastric evacuatory function in health and in the duodenal ulcer disease. I. Types of solid meal distribution within the stomach and their relation to gastric emptying.

Solid meal distribution patterns within the stomach, as well as gastric emptying were studied in 35 healthy subjects and 34 duodenal ulcer patients. Inspection of the serial scintiscans., recorded during each gastric emptying examination, revealed three different intragastric meal distribution patterns. Distinction between the three types of meal distribution within the stomach was facilitated by the use of the proximal: distal stomach width ratio (P:D), a parameter with a proven reproducibility. The P:D ratio less than 0.7 characterized Type III stomach, whereas 0.7 less than P:D less than 1 + 45 and P:D greater than 1.45 described Types I and II, respectively. Attention was focussed on the relationship of the intragastric meal distribution patterns to total stomach emptying. A significantly higher incidence of Type III stomach in women was accompanied by delayed gastric emptying and different emptying pattern when compared to men (T1/2 107.4 +/- 5.74 versus 84.2 +/- 3.21 min, mean +/- SEM p less than 0.001). Irrespective of the equally frequent occurrence of the relevant stomach types in normals and in duodenal ulcer patients, increased gastric emptying was observed in the latter group T1/2 90.8 +/- 3.30 versus 76.7 +/- 3.82 min, means +/- S.E.M., p less than 0.01). The necessity of establishing the normal range of gastric emptying parameters separately for men and women is concluded.

Adult↗
PubMed1987

Gastric emptying in active duodenal ulcer.

Gastric emptying of a radiolabeled solid-phase meal was studied in 45 patients with an active duodenal ulcer, and in 32 healthy controls. Precise analysis of the course of gastric emptying was possible with the use of the function gamma approximation and power-exponential fitting. Unchanged lag phase followed by a small but significant acceleration of gastric emptying was found in duodenal ulcer patients as compared with healthy controls.

Adult↗
PubMed1986

Gastric emptying in obesity.

The gastric emptying, expressed as the half-emptying time (T1/2) and mean transit time (MTT90), in 31 obese and 21 control women was studied using a radionuclide technique. No correlation between body weight and body surface area and gastric emptying rates could be found. T1/2 was slightly shorter and MTT90 faster in the obese women than in the controls. There is little chance that a subtle difference in gastric emptying is of any importance in the pathogenesis of obesity.

Adolescent↗
PubMed1982

The influence of noise and vibration upon creatine kinase activity in blood serum.

The investigations comprised part of the workers employed in a factory of prefabricated concrete elements. The creatine kinase (CK) activity was determined before and after a day's work in the following groups of workers: I-exposed to noise and vibration exceeding the allowed norm, II- exposed to noise, performing the same hard physical work as group I and exposed to vibration not exceeding 79dB in particular octave bands, III- practising physical work a group I and II but in environment free from noise and vibration, and a control group of persons (C) not exposed to any of the tested factors (vibration, noise, work). The obtained results indicate that the determination of the CK activity may serve as a test of exposure to vibration and noise.

Adult↗
PubMedDate not supplied

Effect of calcitonin on gall-bladder volume in man.

The effect of increasing intravenous doses of synthetic salmon calcitonin (0.0044, 0.0088, 0.0175, and 0.0350 iu/kg per min) versus placebo on the fasted gall-bladder volume was assessed in seven normal subjects according to a double-blind study protocol. In addition, the action of calcitonin on meal-induced gall-bladder emptying was examined. Gall-bladder volumes were measured by means of real-time ultrasonography. Calcitonin evoked a dose-dependent relaxation of the fasted gall-bladder. A statistically significant increase of the fasted gall-bladder volume was observed with 0.0175 (23.4 +/- 5.5 cm3 placebo versus 33.9 +/- 7.7 cm3 calcitonin, P less than 0.001) and 0.0350 (21.4 +/- 4.6 cm3 placebo versus 36.1 +/- 8.4 cm3 calcitonin, P less than 0.01) iu/kg per min calcitonin, whereas a mean increase of the gall-bladder volume amounted to 32.1% and 46.5%, respectively. A significant delay of the gall-bladder emptying after calcitonin was reflected by a decrease of the ejection fraction: 23.2 +/- 8.3% calcitonin versus 57.8 +/- 6.9% placebo (P less than 0.02) at 20 min, and 40.5 +/- 8.8% calcitonin versus 67.2 +/- 3.8% placebo (P less than 0.02) at 30 min after the test meal. Calcitonin is concluded to have a potent relaxing effect on the human gall-bladder.

Adult↗