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Biomedical subjects

K Ishida

Publications and source records attributed to K Ishida.

At least 577 records · Page 32Linked to original sources
PubMed1981

[Prediction of the location of left anterior descending coronary artery disease by anterior echocardiography and esophageal echocardiography (author's transl)].

In 11 normal subjects and 30 patients (pts) with left anterior descending coronary artery (LAD) lesion, the left ventricular anterolateral wall (LVAW) was investigated by esophageal echocardiography (Eso Echo) and the interventricular septum (IVS) by conventional anterior echocardiography (Ant Echo). The location of LAD obstruction, either proximal (20 pts; P-group) or distal (10 pts; D-group) to the first septal branch, was confirmed by coronary arteriography. Twenty-two of the 30 pts with LAD lesion had anteroseptal myocardial infarction (ASMI) and the remaining 8 had angina pectoris. Of the 30 pts, 20 pts including 13 pts with ASMI had normal systolic excursion of IVS. On the other hand, LVAW excursion was below 8 mm in 28 of the 30 pts with LAD lesion compared to the value of the normal subjects (10.8 +/- 1.7 mm; range = 8--13 mm). The sum of the values of IVS and LVAW excursions in the pts with ASMI was significantly lower in the P-group than those in the D-group (p less than 0.001). In the P-group, the beginning of both systolic IVS and LVAW excursion delayed significantly (IVS: 118 +/- 47 msec, LVAW: 121 +/- 44 msec from Q wave on ECG) than those of normal subjects, while in the D-group only LVAW excursion was delayed (142 +/- 23 msec) compared to that of IVS (84 +/- 32 msec). Thus, the analysis of the motion of IVS and LVAW obtained by Ant Echo and Eso Echo is useful in predicting the presence of absence as well as the location of LAD lesion.

Aged↗
PubMed1981

[Left ventricular end-systolic pressure and wall thickness relation for the assessment of regional myocardial contractility in man (author's transl)].

In 28 patients (pts) (5 normal subjects (N), 12 pts with valvular heart disease, 6 with cardiomyopathy, and 5 with ischemic heart disease), left ventricular (LV) pressure was measured using Millar's catheter tip transducer simultaneously with LV posterior wall thickness (W) by echocardiography. After the control recording, LV peak systolic pressure was altered by about 30 mmHg from the control level by angiotensin (20 ng/kg/min) or nitroprusside (1 gamma/kg/min) to attain two (18 pts) or three (10 pts) different end-systolic pressure points, determined after the steady state was achieved. LV end-systolic pressure and wall thickness (P-W) relation a the three different end-systolic pressure points was found to be linear (r = 0.996) in each of the 10 pts, suggesting that end-systolic P-W relation is independent of afterload. Isoproterenol infused in 4 pts, which led to an increase in peak positive (+) dp/dt by a mean of 28%, increased the slope of the P-W relation by 43.4% of the control value (P less than 0.001), while propranolol, which led to a decrease in peak (+) dp/dt by a mean of 16.7%, reduced the slope by 27.3% (p less than 0.001). This indicates the sensitiveness of the slope of P-W relation to the inotropic change of the myocardium. In N, the slope of the P-W relation was -29.7 +/0 6.0 mmHg/mm (mean +/- SD), while the value in 4 pts with decreased functional capacity (NYHA III or IV) was significantly lower (-13.7 +/- 2.9 mmHg/mm; p less than 0.001). Thus, the present study suggests that the slope of the end-systolic P-W relation is useful in assessing regional myocardial contractility in man.

Adult↗
PubMed1980

Novel post-column derivatization method for the fluorimetric determination of norepinephrine and epinephrine.

A novel method is described in which catecholamines are converted into fluorescent products by heating in alkaline borate buffer. The method was applied to the determination of norepinephrine and epinephrine after separation by high-performance liquid chromatography using a pellicular, strong cation exchanger. The new system is simpler than the system based on the trihydroxyindole reaction. It is suitable for the measurement of catecholamines in the range of 0.25-20 ng. The assay of catecholamines in human urine is also described.

Borates↗
PubMed1979

Experimental hematogenous Candida endophthalmitis: diagnostic approaches.

Anterior chamber aspiration and vitreous aspiration were evaluated as diagnostic procedures for establishing a specific microbiological diagnosis in the rabbit model of hematogenous Candida endophthalmitis. Vitreous aspiration was the most successful procedure, confirming the diagnosis of hematogenous Candida endophthalmitis in 62% of eyes with documented intraocular infection. When animals with only the most severe clinical endophthalmitis were considered, vitreous aspiration confirmed the diagnosis in 89% of eyes evaluated. Vitreous aspiration correlated well with the extent of clinical endophthalmitis, as well as with postmortem, whole-vitreous cultures. Gram staining of the aspirate was additive to culture results in confirming the diagnosis. Anterior chamber aspiration was positive in only 1 of 58 eyes evaluated (1.7%). Additionally, muscle biospy was evaluated in this study as a tool for establishing a microbiological diagnosis in the rabbit model of disseminated candidiasis. Only 2 of 131 biospy specimens contained detectable Candida. Although vitreous aspiration may be associated with ocular complications, in certain clinical settings this procedure may be valuable in establishing the definitive microbiological diagnosis of hematogenous Candida endophthalmitis.

Animals↗