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Biomedical subjects

K Eriksson

Publications and source records attributed to K Eriksson.

At least 127 records · Page 7Linked to original sources
PubMed1984

Screening for iron overload using transferrin saturation.

People with parenchymal iron overload exhibit an elevated serum iron concentration and a raised transferrin (TIBC) saturation early in the course of the disease. They can therefore be detected by simple laboratory tests before organ damage has occurred. In this study running for 2 months, 10512 samples from approximately 8750 patients and blood donors were examined in a county hospital in Central Sweden. Abnormal TIBC saturation (greater than 70%) was found in 1.7% of the samples. This abnormality was caused by physiological fluctuations in serum iron in 44%, liver disease in 22%, blood disorder in 10%, iron therapy in 10.5% and parenchymal iron overload in 11.5%. The diagnosis of iron overload was confirmed by measuring the serum ferritin concentration and by performing the desferrioxamine test, liver biopsy, quantitative phlebotomy and family studies including HLA typing. We found a prevalence of iron overload of 0.24%. This figure is almost certainly too low because some affected patients were probably lost because of TIBC desaturation induced by inflammatory conditions.

Adult↗
PubMed1984

Microcracking in dog bone under load. A biomechanical study of bone visco-elasticity.

Entire diaphyseal bones from adult dogs were repeatedly loaded in torsion. The residual deformation after unloading from the non-linear deformation range was found to decrease with time. Acoustic-emission signals typical for micro-cracking were registered not only during loading in the non-linear deformation range but also during the initial phase of the following unloading. The initial torque and twist required for further micro-cracking decreased for every subsequent load-cycle, i.e. with the amount of cracking already formed. These observations are indications of visco-elastic properties of bone material.

Animals↗
PubMed1983

Recurrences after initial dislocation of the shoulder. Results of a prospective study of treatment.

During the years 1978 and 1979, the results in 257 patients with a primary anterior dislocation of the shoulder were prospectively studied. The patients were less than forty years old and had been treated at twenty-seven Swedish hospitals. Thirty-two patients had a fracture of the greater tuberosity, but none of them reported having any further dislocations within two years after treatment, while 32 per cent of the patients without this fracture had a redislocation during the same period. The incidence of fractures of the greater tuberosity varied with the age of the patient; the highest rates were in the age groups of twelve to thirteen years and thirty-four to forty years (43 and 30 per cent, respectively), while in the age group of twenty to twenty-two years this injury was found in only 3 per cent of the patients. Chip fractures of the glenoid rim were found in 8 per cent of the patients, most of whom were in the older age groups. Impression fractures in the posterior part of the humeral head were demonstrated in 55 per cent of the patients and were not associated with a significantly higher rate of recurrence of dislocation. One hundred and twelve patients used an immobilization device for three to four weeks, while 104 patients began to use the shoulder as early and as freely as possible. At the two-year follow-up the groups showed an equal rate of recurrence of dislocation. In the age group of twenty-two years or younger nearly 50 per cent of the patients had one or more recurrences, regardless of treatment. In the two older age groups (twenty-three to twenty-nine and thirty to forty years old), the incidence of recurrence was 25 per cent or less.

Adolescent↗
PubMed1982

[What is meant by the science of patient care?].

The study had two main purposes: to develop further a specific patient care process model and to develop a curriculum approach based on the model. These two problem areas depend on other problems, which have to be solved when a vocation develops and moves into academic setting. It is important to form a new foundation of knowledge and to educate a first generation to be able to command this new knowledge. The science of care is in the preparadigmatic phase and is about to enter into the normal scientific period. The medical paradigm is confronted today with the phase in which it must look for new possibilities, in other words, with a revolutionary phase. Therefore one can assume that the concepts of nursing science and those of medical science are not completely in agreement with each other.

Health Services Research↗
PubMed1980

The effects of dietary thiamin on voluntary ethanol drinking and ethanol metabolism in the rat.

1. The influence of a deficiency or surplus of thiamin in the diet on voluntary ethanol consumption, ethanol elimination rate and blood acetaldehyde concentration was studied in rats. 2. Both the high-thiamin diet containing 20 mg thiamin hydrochloride/kg and the thiamin deficient diet containing no measurable thiamin produced obvious functional effects on thiamin metabolism in rat tissues after 4 weeks as demonstrated by measurements of the blood transketolase (sedoheptulose-7-phosphate: D-glyceraldehyde-3-phosphate glycolaldehyde-transferase; EC 2.2.1.1) activity and the extent of thiamin pyrophosphate-stimulation of the enzyme. 3. During the first week on the test diets the prospective ethanol free-choice groups had 1.72 M-ethanol as their only drinking-fluid. Subsequently they had a choice between ethanol and tap water for three weeks. During the free-choice period the rats on the high-thiamin diet drank only one-fifth as much ethanol as the rats given the optimum diet with 4 mg thiamin hydrochloride/kg. 4. The thiamin-deficient rats showed a significant tendency to increase ethanol drinking, when intake was expressed relative to total energy intake, but their intake of ethanol on a g/kg body-weight basis was approximately the same as that of the group given the optimum-diet. 5. The observed differences in voluntary ethanol drinking associated with different levels of dietary thiamin cannot be explained by changes in the ethanol elimination rate or the acetaldehyde accumulation in blood during the oxidation of ethanol.

Acetaldehyde↗
PubMed1980

Material reaction of diaphyseal bone under torsion. An experimental study on dogs.

The formation of microcracks in entire canine diaphyseal bones under torsional loads was studied. The acoustic emission technique was used to register the stress waves which were generated in the bones by crack formation and/or growth. Acoustic emission signals, characteristic of crack formation and/or growth, were recorded exclusively during the non-linear deformation. This is a strong indication of the elastic behaviour of diaphyseal canine bone material.

Acoustics↗
PubMed1980

The rigidity of human fingernails: a biophysical investigation on influencing physical parameters.

(A) The property of withstanding bending and buckling in a composite material such as the nail is best described by such terms as rigidity or stiffness. (B) The physical property of rigidity can be understood from the macromolecular orientation of the keratin filaments and the cellular architecture of the dorsal and ventral nail plates. (C) The rigidity is influenced by factors such as the water content of the nail material. Specimens investigated must therefore be well equilibrated prior to the measurements. (D) Detergents, organic solvents, oils etc. are factors which are likely to influence nail rigidity.

Biomechanical Phenomena↗
PubMed1979

Peripheral neuropathy and myopathy. An experimental study of rats on alcohol and variable dietary thiamine.

The effects of variable dietary thiamine concentrations (deficient, normal, surplus) on the development of alcoholic neuromyopathy in rats exposed for 36 weeks to 10-25% (v/v) ethanol or water (control group) as the sole drinking fluid were studied by histological and electrophysiological methods. Abnormalities in the structure of the sciatic nerve (phagocytosis, myelin abnormalities, increase in nonspecific cholinesterase activity) and tibial muscles (angular atrophic fibers, group atrophy, fibre necrosis) developed more frequently in animals on diets deficient in thiamine than in animals on diets with normal or surplus thiamine, and more frequently in animals drinking alcohol and water than in those drinking water alone. No differences were observed between the different groups in the number of perivascular sympathetic nerves, in the motor nerve conduction velocities and in the muscle fibrillation potentials. Thus, thiamine deficiency, established as a significant reduction of red blood cell transketolase activity, seems to have a deleterious effect on the peripheral nerves and muscles. The effect is enhanced by the simultaneous consumption of ethyl alcohol.

Alcoholism↗
PubMed1979

Tendinography for diagnosing injuries to tendons and ligaments.

A radiographic method of tendinography is described. In rabbits no inflammatory reaction in the Achilles tendon was observed 12 to 15 days after injection of contrast medium. Effects of examination of two healthy subjects and a patient with a traumatic condition are described. Suitable amounts and concentrations of contrast medium for examinations of Achilles tendon and cruciate ligaments are discussed.

Achilles Tendon↗