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Biomedical subjects

K Eriksson

Publications and source records attributed to K Eriksson.

At least 145 records · Page 8Linked to original sources
PubMed1979

Non-linear properties of diaphyseal bone. An experimental study on dogs.

The deformation of entire long bones from dogs has been studied in torsion. The load-deformation relationship is non-linear prior to ultimate failure and repeated successively increased loading and unloading in the non-linear range is found to reduce the stiffness of the bone. The non-linearity of the curve is assumed to be due to a change in the geometry of the bone originating from formation of small cracks in the cortex. The bone material of entire long bones from dogs seems to be linearly elastic for all torques.

Animals↗
PubMed1978

Myopathy associated with chronic alcohol drinking. Histological and electrophysiological study.

Muscles of the lower legs of rats given 25% ethanol in water ad libitum for up to 9.5 months were studied using histological, histochemical and electrophysiological techniques. Ethyl alcohol was substituted for about 20% of the total calorific input of the animals. The observations were compared with the structure of the gastrocnemius muscle of five alcoholics with clinical neuropathy. Fibrillation potentials and angulated atrophic fibers were observed in the muscles of animals on alcohol for 9.5 months. No fiber type grouping was present. There was also phagocytosis of the muscle fibers and changes in their internal structure, as reflected by the distribution of NADH-diaphorase. The observed muscle changes in the alcoholics and those in the experimental animals on alcohol differed mainly quantitatively, the only exception being the presence of fiber type grouping in the biopsies from the alcoholics.

Alcoholism↗
PubMed1978

Dietarily-induced changes in voluntary ethanol consumption and ethanol metabolism in the rat.

1. The voluntary ethanol consumption, ethanol elimination rate and blood acetaldehyde level after intraperiotoneal injection of ethanol were studied in rats receiving diets with highly imbalanced proportions of dietary protein, carbohydrate and fat. 2. The rats, which received the low-protein diet containing 0.05 of the total energy as protein, 0.80 as carbohydrate and o.15 as fat, drank only approximately half as much ethanol as did the control group, which received 0.30 of its total food energy from protein, 0.55 from carbohydrate and 0.15 from fat. Ethanol elimination rate in the low-protein group was decreased and the blood acetaldehyde level after ethanol injection was markedly increased. 3. On the high-fat diet, which contained 0.30 of the total energy from protein, 0.05 from carbohydrate and 0.65 from fat, the rats drank significantly more ethanol than did the rats on the control diet; their ethanol elimination rate was decreased but their blood acetaldehyde level was not affected. 4. In conclusion, the strong decrease in voluntary ethanol drinking by the low-protein group may have been caused by the increased acetaldehyde accumulation in the blood, but a particularly low blood acetaldehyde level was not one of the factors inducing excessive ethanol drinking in the high-fat group.

Acetaldehyde↗
PubMed1978

Torsional strength and geometry of diaphyseal bone. An experimental study on dogs.

A previously presented method for measuring the torsional strength of diaphyseal bones has been used to study the effect of direction of twist upon the torsional strength and stiffness of diaphyseal canine bones. No significant effect of the direction of twist upon the studied properties has been found. The reason for the observed twist direction independence of the torsional strength and stiffness is assumed to be the adaptation of the diaphyseal bone architecture to functional demands.

Animals↗
PubMed1977

The effects of chronic ethanol consumption on goniomitosis in the rat.

Male rats, provided with dissimilar diets with regard to thiamine (deficient, normal and superfluous) received either water or alcohol (7-20%: w/v) as the only supply of liquid for 4-7 months. Mitotic acitivity was very low in the spermatogonia of many of the individuals especially those belonging to the alcohol groups. The frequency of cells with visible chromosomal defects was invariably quite low. It seems that combining abnormal thiamine supply with alcoholism does not lead to a drastic increase in the frequency of chromosomal aberrations.

Alcoholism↗
PubMed1976

Enzyme polymorphism in feral, outbred and inbred rats (Rattus norvegicus).

Polymorphism at 25 loci coding for liver enzymes was studied in two feral, three outbred and three inbred rat strains by starch gel electrophoresis. No variation was found at 14 loci, and a low degree of polymorphism was detected at three. Eight loci were polymorphic in more than one population. The average degree of heterozygosity per locus per individual feral rat was 0-07. The degrees of heterozygosity observed in the outbred and inbred strains were lower, from 0-006 to 0-012. Contrary to expectation, the inbred strains were neither monomorphic nor appreciably less heterozygous than the outbred ones. The heterozygosity of the inbred strains was primarily due to two polymorphic loci, G-3-pdh and alpha-Gpdh. The reason for this polymorphism is probably the superior homeostasis of the heterozygotes.

Animals↗
PubMed1976

Goniomitosis in rats affected by mycoplasma or macrolides.

Infection with Mycoplasm pulmonis caused a slight increase in the incidence of chromosome breaks in goniomitotic cells of the rat testis. No differences existed between healthy and infected rats in the frequency of mitotic divisions, measured as the number of metaphases per slide. The macrolide antibiotics erythromycin and tylosin are widely used as antimycoplasmal drugs. Erythromycin was given to healthy rats intramuscularly at a concentration of 20 mg/kg, and tylosin perorally in the drinking water at a concentration of 0.1%, both for 10 days. Neither drug induced an increase in the incidence of chromosome breaks in the spermatogonia. But both these macrolides caused a definite reduction in the therapy of cell division. With erythromycin, this effect had disappeared 18 days after the end of treatment.

Animals↗
PubMed1976

Goniomitosis in rats subjected to ethanol.

Prolonged compulsory consumption of ethyl alcohol does not increase the incidence of chromosomal abnormalities in the spermatogonial cells of the rat. This was the result of an experiment in which rats given a nutritionally adequate diet received 10% (v/v) ethyl alcohol as their only supply of liquid for 70 days.

Animals↗