Treatment of eczema herpeticum with vidarabine.
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Adolescent↗
Biomedical subjects
K E Greer
Publications and source records attributed to K E Greer.
Minocycline-induced pigmentation at sites of cutaneous inflammation.
In four cases of minocycline hydrochloride-induced cutaneous pigmentation, blue-gray discoloration in sites of cutaneous inflammation was seen in all cases. An additional finding of generalized, brown hyperpigmentation with accentuation in sun-exposed areas was noted in one. Although all of the patients had used relatively high doses of medication, the variable duration of therapy before pigmentary changes and dearth of similar reports suggest an idiosyncratic response to this commonly used medication. Histochemical stains and electron microscopic studies suggest hemosiderin or a pigment with similar staining properties; a minocycline degradation product, however, cannot be discounted.
Acne Vulgaris↗
Bullous amyloidosis.
The variety of cutaneous lesions in primary systemic or multiple myeloma-associated amyloidosis is impressive and includes purpura, waxy papules, tumors, plaques, alopecia, and, rarely, bullae. We report a patient in whom the diagnoses of amyloidosis and multiple myeloma were established after he presented with bullae and extensive infiltrated, purpuric plaques. Immunoelectrophoresis of the blister fluid revealed an IgA kappa monoclonal protein similar to that found in the patient's serum and urine.
Aged↗
Benign mucous membrane pemphigoid in association with internal malignancy.
A patient with benign mucous membrane pemphigoid was found to have metastatic carcinoma of the lung. With so few similar case reports in the literature, the possible association of this blistering disorder with internal malignancy cannot be disclaimed totally, as appears to be the case for bullous pemphigoid which has been studied much more extensively.
Adenocarcinoma↗
Primary oxalosis with livedo reticularis.
Livedo reticularis developed on the lower extremities of a 37-year-old woman with primary oxalosis and renal failure that was treated by hemodialysis. Biopsy results of the involved skin indicated oxalate crystals in the walls of the blood vessels of the dermis and subcutaneous tissue. Oxalosis with vascular involvement should be included in the long list of causes of livedo reticularis.
Adult↗
Electrocardiographic changes associated with multiple yellow jacket stings.
A previously healthy 38-year-old man was stung multiple times by yellow jackets without any signs of anaphylaxis being observed. An electrocardiogram taken 16 hours later revealed episodes of wandering atrial pacemaker, junctional rhythm, and intermittent premature ventricular contractions. These arrhythmias disappeared spontaneously.
Adult↗
Sporotrichoid cutaneous infection due to Mycobacterium chelonei.
Extensive cutaneous lesions that simulated sporotrichosis developed in a patient. Mycobacterium chelonei, a facultative pathogen that exists as a saprophyte in the environment and rarely produces clinical disease in humans, grew from culture of biopsy material. There was no evidence of visceral involvement, and the lesions healed spontaneously within six months.
Aged↗
Toxic epidermal necrolysis.
Toxic epidermal necrolysis (TEN) is a disorder characterized by the sudden onset of widespread erythema and tenderness of the skin with rapid progression to desquamation of sheets of epidermis, resembling scalding. Although the clinical picture is similar in many instances, toxic epidermal necrolysis is subdivided into two main clinicopathologic types, those due to staphylococcal infections, and the nonstaphylococcal variant. It occurs as the result of a number of causes, including specific exfoliative toxin-producing staphylococci, drugs, vaccines, and the graft vs. host reaction. Differentiation of these types is important, both for therapeutic and prognostic reasons.
Adult↗
Intracranial calcifications and dyskeratosis congenita.
We describe two brothers with dyskeratosis congenita and intracranial calcifications. The calcifications were massive, approximately symmetric, and showed a predilection for the basal ganglia and dentate nuclei. No underlying causes for this finding were identified. Idiopathic familial intracranial calcification of this type has been described, but an association with dyskeratosis congenita has not previously been observed.
Adolescent↗
Cystic chromomycosis due to Wangiella dermatitidis.
Chromomycosis is a chronic, slowly progressive disease of the skin and subcutaneous tissue produced by several species of dematiaceous or pigmented fungi, especially Phialophora gougeroti. Verrucous nodules and flattened annular plaques are the most frequently reported skin lesions in chromomycosis, but deep abscesses and cystic lesions have also been reported. We describe herein a case of cystic chromomycosis due to Wangiella dermatitidis that developed following a nonprenetrating injury to the thumb.
Chromoblastomycosis↗
Cutaneous manifestations of acute carbon monoxide poisoning.
A patient with acute carbon monoxide poisoning due to leakage of gas from the exhaust system in his automobile noted edema and blister formation over large areas of the skin of one half of his body. Rhabdomyolysis, acute but transient renal insufficiency, and hemolytic anemia developed subsequently.
Acute Kidney Injury↗
Hereditary sclerosing poikiloderma.
Three persons with hereditary sclerosing poikiloderma were studied to find any clue to explain the mechanism involved in producing the cutaneous lesions which are so striking clinically and also evident histologically. Investigational studies included a blood chemistry screen, chromosome analyses, and skin biopsies evaluated by routine stains as well as by electron microscopy and direct immunofluorescence. No mechanism for the production of the clinical and histological changes in the dominantly inherited disorder was found.
Adolescent↗
Leser-Trélat associated with acute leukemia.
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Acute Disease↗
Disseminated actinomycosis.
A case of pulmonary actinomycosis with dissemination to skin, subcutaneous tissue, and bone is described. The cutaneous lesions were characterized by tender swellings and fluctuant nodules and were the presenting manifestation of the disease. Typical sulfur granules were present in the skin and pleural biopsies. Actinomyces israelii and its synergistic bacteria Actinobacillus actinomycetemcomitans were cultured from skin and pleura. Clinical improvement, with resolution of lung and disseminated skin lesions, was prompt with parenteral penicillin therapy.
Actinomycosis↗
Lymphomatoid papulosis and other pseudomalignancies of the skin.
Lymphomatoid papulosis, keratoacanthoma, juvenile melanoma, and atypical fibroxanthoma are clinically benign yet histologically malignant cutaneous disorders which have been designated as pseudomalignancies of the skin. Other disorders which may be classified as pseudomalignant include angiolymphoid hyperplasia with eosinophilia, nodular fasciitis, lymphocytoma cutis, actinic reticuloid and, occasionally, insect bites. A patient with lymphomatoid papulosis is reported and the pseudomalignancies of the skin are briefly reviewed.
Aged↗
Unusual cutaneous manifestations of sarcoidosis.
The diagnosis of sarcoidosis is best established when there is evidence of granulomatous involvement in two or more organs. Three patients with unusual cutaneous manifestations of sarcoidosis, including palmar and follicular lesions, nonscarring alopecia, and widespread plaque or erythrodermic sarcoidosis, are reported. In all three patients the skin biopsy was important in establishing the diagnosis.
Adult↗
Multiple osteolytic lesions in a patient with mycosis fungoides.
Skeletal lesions that were clinically significant and roentgenographically demonstrable developed in a patient with mycosis fungoides. Biopsy specimens from skin plaques and tumors and from a tibial tumor mass revealed an infiltrate of similar-appearing cells that were compatible with mycosis cells. Bone marrow involvement is not unusual in patients with mycosis fungoides with extracutaneous disease, but destruction of cortical bone in mycosis fungoides, as demonstrated by the patient in this report, is rare.
Biopsy↗
Topical treatment of herpes labialis with chloroform.
The efficacy of topical chloroform treatment of herpes labialis (HL) was evaluated in 50 patients with culture-verified HL. Treatment was begun within 48 hours of lesion onset, with either chloroform or camphor-in-oil placebo applied locally once a day for three days. Patients were observed daily by one investigator who also cultured and photographed the lesions. The photographs were evaluated by two other investigators. By direct observation, the time for scab formation was significantly less in the group treated with chloroform (P less than .01). No difference in time to healing was noted. Blind evaluation of the serial photographs showed a trend for more rapid scab formation and healing in patients treated with chloroform, but the differences were not significant. The minimal benefit derived from topical chloroform therapy of HL does not appear sufficient to recommend its routine use.
Administration, Topical↗