Search PubMed⌕ Search

Biomedical subjects

K E Greer

Publications and source records attributed to K E Greer.

At least 37 records · Page 2Linked to original sources
PubMed1991

Sclerosing panniculitis. A clinicopathologic assessment.

Six patients with well-circumscribed, indurated, inflammatory plaques of the lower extremity are described. Incisional biopsy specimens in each patient revealed fat necrosis, sclerosis, and a lobular panniculitis. These patients are similar to those described under the designations hypodermitis sclerodermaformis or lipodermatosclerosis. The name sclerosing panniculitis is proposed to unify these conditions. The pathogenesis is unknown, although a role for venous stasis or previous thrombophlebitis has been proposed. Systemic or local anti-inflammatory therapies have not been clinically effective.

Adult↗
PubMed1990

White sponge nevus.

A case is presented of white sponge nevus involving the vaginal, labial, and oral mucosae of a 34-year-old woman. White sponge nevus is a rare, benign, autosomal dominant leukokeratosis that predominantly affects the oral mucosa. Less frequently, it affects extraoral sites including the vulvovaginal mucosa. In this case, histopathologic study of vulvovaginal lesions, subsequent examination of extragenital mucosae, and inquiry into the family history led to the correct diagnosis. The genetics, clinical appearance, and histopathology of white sponge nevus are discussed in relation to the differential diagnosis of oral and vaginal leukokeratoses.

Adult↗
PubMed1989

Eruptive disseminated lobular capillary hemangioma (pyogenic granuloma).

A 43-year-old man reported a 2-month history of numerous widespread vascular lesions that had developed suddenly on his scalp, trunk, and extremities. The lesions were 2 to 6 mm in diameter, firm, dark red papules that bled easily with minor trauma. Histopathologic examination of four lesions revealed lobular capillary hemangioma, also known as pyogenic granuloma. Treated lesions did not recur after surgical excision or electrocauterization. Five months after the onset of the eruption, no new lesions were developing, and some were resolving spontaneously after bleeding. Eruptive, disseminated lobular capillary hemangioma is a rare, self-limited cutaneous disorder that occurs in otherwise healthy persons.

Adult↗
PubMed1988

Congenital self-healing (transient) mechanobullous dermatosis.

A neonate with a congenital mechanobullous disorder is described and compared with similar patterns from the literature. The blisters were subepidermal, remitted within a few months, and have not recurred on long-term follow-up. The relation of the congenital self-healing mechanobullous dermatoses to epidermolysis bullosa is unclear.

Blister↗
PubMed1985

Contemporary therapy for acne. What, when, and how to prescribe.

The use of topical tretinoin (Retin-A) for comedonal lesions, benzoyl peroxide for inflamed papules and pustules, and topical or oral antibiotics for more severe or widespread disease gives excellent results for the majority of patients with acne. At present, oral isotretinoin (13-cis-retinoic acid) (Accutane) should be reserved for patients with severe nodulocystic acne whose condition has not responded to an accepted therapeutic regimen. Good patient rapport and follow-up are essential in the management of this common disease.

Acne Vulgaris↗
PubMed1985

Eosinophilic cellulitis (Wells' syndrome).

Two patients with eosinophilic cellulitis are reported and 22 additional cases from the literature are reviewed. Cutaneous lesions are variable in appearance and may be confused with cellulitis, urticaria, insect bites, or contact dermatitis. Microscopically, there is a dense dermal infiltrate of eosinophils. Subsequently, granulomatous features with characteristic "flame figures" become apparent. Peripheral eosinophilia is common. The etiology of eosinophilic cellulitis is unknown, although a hypersensitivity mechanism is suspected. Treatment with systemic corticosteroids is frequently effective, but the disease is often characterized by relapses that can occur for several years.

Adolescent↗
PubMed1984

Low-grade clear cell eccrine carcinoma.

Two patients had facial tumors that had a distinctive microscopic appearance. Each consisted of multiple nests of glycogen-filled clear cells dispersed in the dermis and associated with a hyalinized, collagenous stroma. There were also ductular features suggestive of eccrine differentiation. The lesions had a locally infiltrative microscopic appearance, and one involved the subcutaneous fat and skeletal muscle. Although neither tumor has recurred following excision, we believe that they are low-grade eccrine carcinomas and that they may represent a distinctive, albeit rare, subtype of adnexal neoplasm.

Aged↗
PubMed1983

Acute febrile neutrophilic dermatosis (Sweet's syndrome) and myeloproliferative disorders.

Acute febrile neutrophilic dermatosis (ND) consists of the abrupt onset of red, tender, cutaneous plaques on the face, extremities, and upper trunk, accompanied by fever, malaise, and neutrophilic leukocytosis. Histologically, there are distinctive, dense, dermal infiltrates of neutrophils. Response to systemic steroids is dramatic. This report describes four patients with leukemia or preleukemia and ND (LND), reviews reports of 12 similar patients, and compares LND with ND in otherwise healthy individuals (idiopathic ND, IND). Although lesions of LND more frequently had vesiculobullous appearances or location on mucous membranes, this study showed no consistent difference between LND and IND with regard to cutaneous signs, symptoms, histologic findings, and response to therapy. The first episode of LND either preceded or followed documentation of the myeloproliferative disorder, and the most common associated hematologic conditions were acute myeloid or myelomonocytic leukemia. Moderate to severe anemia was present in nine of ten patients whose first episode of LND preceded the discovery of the hematologic condition by eight months or less. The presence of anemia is the most obvious and readily detectable difference between LND and IND. The possibility of an underlying myeloproliferative disorder should be considered in all patients with ND, and LND should not be confused with infectious complications in patients known to have myeloproliferative disorders.

Acute Disease↗
PubMed1983

Subcutaneous neutrophilic infiltrates in acute febrile neutrophilic dermatosis.

A patient had an evolving hematologic disorder, accompanied by tender, red, subcutaneous nodules. Histologically, there were dense neutrophilic infiltrates confined to the subcutaneous adipose tissue. Three months later, a typical episode of acute febrile neutrophilic dermatosis (ND) developed in the patient, and she was found to have acute myeloid leukemia. In addition to the dermis, the neutrophilic infiltrates of ND occasionally involve the subcutis. As seen in our patient, the infiltrates are rarely limited to the subcutaneous tissue.

Acute Disease↗