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Biomedical subjects

K E Greer

Publications and source records attributed to K E Greer.

71 records · Page 4Linked to original sources

Skin lesions induced by penicillamine. Occurrence in a patient with hepatolenticular degeneration (Wilson Disease).

A 41-year-old patient with hepatolenticular degeneration (Wilson disease), who had been treated for 15 years with penicillamine, developed small white papules at sites of venipuncture in the antecubital fossae and at surgical suture sites. Histologically, these papules showed focal areas of connective tissue degeneration in the dermis, but there was no evidence of inclusion cysts. The changes most likely resulted from the effect of penicillamine on new connective tissue formation at the sites of injury. The patient also developed crinkling of the skin of her face and neck while on the penicillamine regimen, and these changes were attributed, at least in part, to the effects of this drug on connective tissue.

Adult↗

Nevus sebaceous and syringocystadenoma papilliferum.

A 52-year-old patient was admitted to the hosptial for evaluation of hypertension. He had two skin lesions, one on the forehead and one in the postauricular area, which had been present since birth. The forehead lesion was a nevus sebaceous and the postauricular lesion was a syringocystadenoma papilliferum. Except for a few patients with widespread nevus sebaceous and syringocystadenoma papilliferum associated with neurologic abnormalities, most of the previously reported patients with these nevi have had solitary lesions of one or the other. An association of nevus sebaceous and syringocystadenoma papilliferum in the same lesion is not uncommon. Despite bleeding and crusting in one of the lesions and despite informing the patient that a malignant neoplasm may develop in these nevi, he refused excision of either of the lesions.

Adenoma, Sweat Gland↗

Pseudomonas botryomycosis.

A patient had cutaneous botryomycosis due to Pseudomonas aeruginosa. The diagnosis of botryomycosis was based on the clinical manifestations, results of bacterial culture, and demonstraction of the Gram-negative organisms by tissue Gram stain of the granules in the dermis and subcutaneous fat. Numerous laboratory tests, including tissue immunofluorescence and special studies with the patient's lymphocytes, failed to demonstrate an abnormality that might help to explain the pathogenesis of the granular tissue reaction in this patient.

Aged↗

Prurigo nodularis and uremia.

Patients with uremia frequently have generalized pruritus that is usually related to a disturbance of calcium and phosphorus metabolism. This report describes three patients with uremia who had prurigo nodularis due to localized scratching and rubbing. The diagnosis of uremia in one case was made when the patient was hospitalized for evaluation of skin lesions.

Adult↗

Acute febrile neutrophilic dermatosis (Sweet syndrome).

We describe the third reported case of acute febrile neutrophilic dermatosis (Sweet syndrome) in the United States. In the majority of reported cases, the patients were female. However, in our case and in the two cases reported previously in the United States, the patients were male. In two of these three male patients, a malignant neoplasm has been found, possibly as a coincidence.

Adult↗

Unilateral laterothoracic exanthem in a child with acute lymphoblastic leukemia.

Unilateral laterothoracic exanthem (ULE) is a rare childhood condition of unknown etiology characterized by a morbilliform rash that usually begins in the axilla and spreads centrifugally. The condition is usually self-limited, does not require specific treatment, and disappears within 4 to 6 weeks. Pruritus may be relieved by oral antihistamines and topical emollients and/or bath oils. We describe ULE in a 6-year-old girl with acute lymphoblastic leukemia, the first report of ULE in a patient with malignancy.

Child↗