Biomedical subjects

K Arnesen

Publications and source records attributed to K Arnesen.

31 records · Page 2Linked to original sources

PubMed1981

[Autopsies in 18 per cent of deaths. Difficulties in recruiting pathologists].

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Autopsy↗

PubMed1977

Encephalitis in ferrets caused by a nonproductive strain of measles virus (D.R.) isolated from patient with subacute sclerosing panencephalitis.

A nonproductive, syncytiogenic strain (D.R.) of measles virus, isolated from a patient with subacute sclerosing panencephalitis (SSPE), was inoculated intracerebrally into ferrets in an attempt to induce subacute encephalitis. Inoculation of freeze-thawed syncytia before immunization was the least effective procedure, and inoculation of live syncytia after immunization with measles virus vaccine was the most effective procedure, for induction of subacute or persistent subclinical encephalitis in the animals. After the latter procedure three of five ferrets developed subacute or subclinical encephalitis, whereas ferrets inoculated with live syncytia without prior immunization consistently contracted acute fatal encephalitis in one to two weeks. The subacute encephalitis in ferrets was characterized by high titers of antibody to measles virus in serum. At the time of sacrifice 1.25, 4.5, or 8.0 months after inoculation, brains of the ferrets showed histologic lesions similar to those characteristic of SSPE, and nonproductive syncytiogenic measles virus was recovered from the brains of two of the animals. All three ferrets had greatly increased concentrations of gamma-globulin in their brains and high levels of neutralizing and hemagglutination-inhibiting antibodies to measles virus. Only one of these animals developed clinical signs 1.25 months after inoculation.

Animals↗

PubMed1977

Ocular encephalitozoonosis (nosematosis) in blue foxes. Polyarteritis nodosa and cataract.

In young blue foxes an association has previously been established between the protozoon Encephalitozoon (Nosema) cuniculi and generalized arterial lesions of the polyarteritis nodosa type. The same vascular changes are found in the posterior ciliary arteries and their intraocular branches of these foxes. Most of the eyes which are thus affected, have a severe cataract. The parasite can easily be demonstrated both in the arteries and the lenses. It is thought that the Encephalitozoon is the cause of the vascular lesions and the cataract, and that possibly an autoimmune reaction is involved.

Animals↗

PubMed1976

Orbitography with a new non-ionizing water-soluble contrast medium.

Metrizamide is a non-ionic water-soluble contrast medium which is isotonic with human blood and tissue fluid at a concentration of 170 mgI/ml. Retrobulbar injection of 3 ml isotonic metrizamide in the muscular conus of rabbits causes slight and inconstant cellulitis, but a similar reaction can also be found after injection of the same amount of saline. It seems probable that the introduction of fluid sufficient to cause an increase in the retrobulbar pressure can cause inflammatory changes in the orbital tissue, and that this is not always caused by the contrast medium itself. Four patients were examined by orbitography with injection of 4 ml isotonic metrizamide. There were no side effects, and the orbitograms showed contrast of good quality. Metrizamide is therefore considered very suitable for orbitography, especially in hospitals where computer-tomography is not yet available.

Animals↗

PubMed1975

Malignant melanoma of the choroid as related to coexistent benign nevus.

Ninety-five cases of malignant choroidal melanoma collected during a 15-year period have been studied with special emphasis on histological type, coexistence of benign nevus, and prognosis. Elements of benign nevus were found in 78% of the cases. The data tend to support the hyposis that most cases of malignant choroidal melanoma have their origin in a preexisting benign nevus, and that the tumours undergo a gradual change from a differentiated to a less differentiated type.

Adult↗

PubMed1974