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Biomedical subjects

K Ando

Publications and source records attributed to K Ando.

At least 775 records · Page 43Linked to original sources
PubMed1981

Increase of T cells in the liver during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.

The localization of thymus-derived lymphocytes (T cells) was investigated in rat liver by the immunofluorescence method during hepatocarcinogenesis with N-2-fluorenylacetamide. In the early stage of carcinogenesis, the number of T cells never increased significantly in livers in which hyperplastic liver nodules (population I) were seen. On the other hand, in the late stage of carcinogenesis, T cells extensively invaded hyperplastic nodules (population II) as well as hepatomas. According to the concept of cell-mediated immunity, hyperplastic nodules in the late stage might have a neoantigen(s) which evokes the response of T cells. Therefore, it may be concluded that populations I and II are biologically distinct lesions in spite of their histological identity.

2-Acetylaminofluorene↗
PubMed1980

Inhibition of artificial lung metastases in mice by pre-irradiation of abdomen.

A phenomenon by which pre-irradiation of the abdomen of mice reduced the lung-colony-forming efficiency of i.v.-injected tumour cells is described. The extent of lung-colony inhibition was shown to depend on both the dose and timing of abdominal irradiation. The maximum inhibitory effect was obtained when mice received 1200 rad gamma-irradiation to the abdomen 5--7 days before tumour-cell challenge, but there was no effect when abdominal irradiation was given 1 or greater than or equal to 14 days before challenge, or when radiation doses were less than 600 rad. In mice less than 3 weeks old, the effect was much less marked than in adults. The target tissue which, when irradiated, exerted the inhibitory influence on lung-colony formation was located in the ventral half of the abdomen in all 4 quadrants, and was probably gut. Radioactively labelled tumour cells were arrested normally in the lungs of irradiated mice, but were cleared more rapidly without evidence of sequestration in the irradiated gut. The most plausible mechanism seems to be that irradiation of the gut induces the production of natrual killer cells with anti-tumour activity, though this has not been conclusively established.

Abdomen↗
PubMed1980

Prelymphomatous and lymphomatous changes in splenomegaly of new zealand black mice.

The incidence of splenomegaly was 39.6% in the nontreated group and 41.0% in the treated group, not significantly different between both groups. Thymic lymphoma group shared 27.6%, while the nonthymic lymphoma group 67.9%, significantly different between both. Histological findings of splenomegaly of the nonlymphoma groups were divided into the following 5 types. 1) follicular form, 2) periarterial lymphatic sheath form, 3) red pulp hematopoietic form, 4) marginal zone form, and 5) red pulp reticulosis form. Histology of the spleen in the lymphoma group resembled each form of cases of splenomegaly in the nonlymphoma group. Lymphoma based upon immune abnormality and specific to this kind of mouse in nonthymic lymphoma continuously takes place from prelymphomatous changes in the nonlymphoma group. Splenic origin and role of mariginal zone of nonthymic lymphoma in murine lymphoma is discussed.

Animals↗
PubMed1980

Microbial degradation of a macrotetrolide miticide in soil.

Macrotetrolide, a miticide consisting of tetranactin, trinactin, and dinactin, was readily biodegradable and hence did not accumulate in soil. [U-C]macrotetrolide was rapidly degraded via its constituent hydroxycarboxylic acids to carbon dioxide and water. In culture media, however, the mixture was hydrolyzed to homononactic and nonactic acids by three strains of Bacillus sp. and two of Micrococcus sp. The latter strains were able to hydrolyze 500 mug of the antibiotic per ml within a few days and to grow in the presence of 4,000 mug of the antibiotic per ml. However, they were unable to assimilate the constituent acids which accumulated in the culture medium.

Journal Article↗
PubMed1980

Transplantable murine plasma cell leukemia with polyclonal gammopathy.

A transplantable plasma cell leukemia cell line, designated as S27, was established from a 12-month-old female New Zealand Black mouse (NZB); serum showed polyclonal elevation of gamma globulin with agarose-agar gel electrophoresis. Immunoelectrophoretic analysis of the serum showed precipitation lines in the IgG1, IgG2a, IgG2b and IgM regions. The amount of serum immunoglobulin increased rapidly with tumor growth. S27 cells proliferating in the spleen contained simultaneously IgG1, IgG2a, IgG2b in the cytoplasm as revealed by indirect immunofluorescence. Membrane immunofluorescence revealed IgG1 on the tumor cell surface. S27 cells were transplantable to syngeneic NZB mice with inoculation of spleen cell suspension, and showed the same histological and immunological findings as those of the original mouse. These findings imply that a single clone of plasma cells has the capacity to produce more than one class of immunoglobulin.

Animals↗
PubMed1980

Action of rennin on casein. III. Effect of alpha s- and beta-casein on the secondary phase.

The action of rennin on kappa-casein was studied as a function of time, employing turbidity measurements at 610 nm and the release of nonprotein nitrogen. kappa-Casein was converted to para-kappa-casein by the action of rennin. The para-kappa-casein aggregated to increase turbidity and then precipitated. Turbidity development was enhanced initially and then retarded severely by increasing concentrations of added alpha s- and beta-casein. The addition of selected amino acids and salts had variable effects on increase of turbidity.

Amino Acids↗