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Biomedical subjects

K Ando

Publications and source records attributed to K Ando.

At least 739 records · Page 41Linked to original sources
PubMed1983

[Two cases of renal arteriovenous fistula].

The first case was a congenital renal arteriovenous fistula in a 33-year-old woman and the second case was a secondary renal arteriovenous fistula in a 67-year-old man. Both cases were seen with asymptomatic gross hematuria without any cardiovascular symptoms. In case 1, the arterial stage of right selective renal angiogram demonstrated a cirsoid type arteriovenous fistula in the right kidney; then, partial nephrectomy was performed. Angiogram of case 2 demonstrated arteriovenous fistula in the lower part of the right kidney. In this case arterial embolization was performed. After reviewing the literature, we believe that partial nephrectomy or arterial embolization is the most useful operative procedure to treat almost all cases of the cirsoid type renal A-V malformation. Conservative treatment of arteriovenous fistula has increased during the post 10 years.

Adult↗
PubMed1983

[The suppressive effect of melilotus extract on the thermal edema of rats].

The effect of melilotus extract (ME) and Esberiven (ES) which contain coumarin on the thermal edema, which is one of high protein edema, was evaluated by both quantitative and qualitative assays. The intraperitoneal injection of ME immediately after burn greatly reduced the amount of swelling and effectively inhibited the occurrence of necrosis and induration in the injured leg-skin as compared with the saline controls in which a 3rd degree of thermal injury was observed. Administration of ES also induced a similar suppressive effect. Furthermore, either intraperitoneal or subcutaneous local injection of ME 4 hr before burn was effective in reducing the edema and thermal injury. No increase of the lymph flow and output of lymphocytes and protein from the thoracic duct lymph was observed in thermally injured rats given an injection of ME. The massive infiltration of neutrophils and macrophages 6 to 24 hr after the subcutaneous injection of ME was histologically observed in the dermal lesion of normal rats. Twenty-four hr later, macrophages, fibroblasts, and lymphocytes became predominant. The present data taken together suggest that ME exerts the suppressive effect on thermal injury by either prior or post administration, and these effects might be induced in an indirect manner, through the action of phagocytic cells accumulated in the injured lesion, not via lymphatic drainages of excess fluid and protein.

Animals↗
PubMed1982

Central noradrenaline metabolism in cerebellar ataxic mice.

Central noradrenaline (NA) metabolism was investigated in 4 types of ataxic mutant mice, weaver, reeler, staggerer and rolling mouse Nagoya (RMN) and hypocerebellar mice experimentally produced by neonatal treatment with cytosine arabinoside (ara-C). As neurochemical markers for synthesis, steady-state level and turnover of NA, we measured tyrosine hydroxylase (TH) activity, NA and total (free + conjugated) 3-methoxy-4-hydroxyphenylethyleneglycol (total MHPG) concentrations in the cerebellum, cerebral cortex and spinal cord. In the weaver and staggerer whose cerebellar weight loss was severe (40 and 21% of controls, respectively), the 3 neurochemical markers were all increased in the cerebellum, and a similar increase was observed in other regions. In the reeler, the 3 markers were also markedly increased in the cerebellum, but no similar pattern of increase was observed in other regions. In the RMN whose cerebellum showed the least weight loss (76% of control), only TH activity and MHPG concentration were increased in the cerebellum and spinal cord but not in the cerebral cortex. In ara-C-treated mice, the neurochemical markers were also increased in the cerebellum, but to a lesser extent in other regions. These results suggest that, although total contents and total activity of these markers per whole cerebellum were significantly decreased, the central NA metabolism was basically enhanced throughout the CNS of the cerebellar ataxic mice irrespective of their cause. The degree and extent of this enhancement appeared to be correlated with the degree of the cerebellar weight loss.

Animals↗
PubMed1982

Metoclopramide-induced Parkinsonism. Clinical characteristics of ten cases.

Clinical characteristics of ten patients with metoclopramide hydrochloride-induced parkinsonism were studied. This condition was found to be more common in aged women and developed subacutely with bilateral symptoms. Clinically, metoclopramide-induced parkinsonism is sometimes accompanied by a rest tremor and may therefore be confused with Parkinson's disease. It is distinct from the latter in that orolingual dyskinesia and postural tremor are often found before the administration of antiparkinsonian drugs. The patients with metoclopramide-induced parkinsonism made a complete recovery within a few months after administration of the drug was discontinued.

Aged↗
PubMed1982

Clinicopathological studies of the Dubin-Johnson syndrome complicated with chronic hepatitis.

Eleven patients with Dubin-Johnson syndrome (DJS) were studied clinicopathologically. In three patients with DJS, concomitant chronic hepatitis was observed. They showed long-standing jaundice with the symptoms of general fatigue and anorexia. Laboratory tests revealed mild hypertransaminasemia, elevated serum bilirubin (over 5.0 mg/dl) and a high level of serum Bromsulphalein (BSP) retention at 45 min (above 18%). Two patients complicated with chronic hepatitis showed a rather slow secondary rise in the BSP excretion curve in comparison with the patients who had no complication. One patient accompanied with the most severe fibrosis showed no secondary rise in the BSP excretion curve. After the treatment of the patient with phenobarbital, however, a secondary rise in the BSP excretion curve appeared and the serum BSP level was also significantly decreased at all points on the BSP excretion curve. Histological examination of the liver revealed the decreased number of the Dubin-Johnson pigments in the patients complicated with chronic hepatitis. Laparoscopically, a patient with a chronic aggressive hepatitis showed a dark gray decololization of the liver surface and another patient with a chronic aggressive hepatitis showed a black color of the liver surface with partial nodule formation.

Adult↗
PubMed1982

Independent roles of prostaglandins and the renin-angiotensin system in abnormal vascular reactivity in Bartter's syndrome.

To clarify the independent roles of prostaglandins and the renin-angiotensin system in the pressor resistance to angiotensin II in Bartter's syndrome, the pressor responsiveness to exogenous angiotensin II was investigated in three patients with the syndrome during the administration of indomethacin synthesis, and captopril is an angiotensin-converting enzyme inhibitor. All the patients showed high plasma renin activity, increased urinary excretion of prostaglandin E, and pressor resistance of angiotensin II. An analogue of angiotensin II that had weak agonistic properties induced a marked fall in blood pressure. Pretreatment with indomethacin (150 mg/day) decreased baseline plasma renin activity and reversed the hypotensive effect of the analogue of angiotensin II. Apparently, our data support the concept that pressor resistance ultimately results from the increase in the concentration of endogenous angiotensin II. However, the augmentation of indomethacin was significantly (p less than 0.01) greater in magnitude than the response obtained with captopril, although the concentration of plasma angiotensin II prior to each infusion of angiotensin II was the same. This observation could be explained by the finding that indomethacin suppressed both systems, but captopril inhibited only the renin-angiotensin system. Evidence presented herein suggests that the abnormalities in the vascular reactivity to angiotensin II may result from, not only the decreased number of receptor sites as a results of the increased concentration of endogenous angiotensin II, but also from the alteration of the end-organ sensitivity to angiotensin II via overproduction of prostaglandins.

Adult↗
PubMed1982

Effect of indomethacin on responses to [sar-ileu]-angiotensin II.

The role of prostaglandins in immediate and sustained pressor responses to [sar-ileu]-angiotensin II was studied, using indomethacin, in 12 patients with essential hypertension. Blood pressure rose within 1 to 2 min, peaked in 4 to 8 min, then fell gradually, but did not return to the baseline level, at the end of 30-min infusion period of the angiotensin II analogue. After 2 days on indomethacin, both immediate and sustained diastolic pressure responses to the analogue (both, P less than 0.01) rose when the basal plasma renin activity (PRA) fell (P less than 0.05); this was associated with 56% suppression of urinary prostaglandin E excretion. Both the immediate and late phases of blood pressure response may be affected by indomethacin, probably not only because of greater availability of angiotensin receptors due to decrease endogenous angiotensin, but also because of alteration of end-organ sensitivity to angiotensin II through inhibition of prostaglandin synthesis. This speculation is supported by the difference in slopes of the regression line relating change in diastolic blood pressure to basal PRA, indicating that there is less effect on controls for a given PRA level than on treated subjects.

1-Sarcosine-8-Isoleucine Angiotensin II↗
PubMed1982

Dynamic responses of active and inactive renin and plasma norepinephrine during exercise in normal man.

Active and inactive plasma renin, plasma angiotensin II, and plasma norepinephrine were measured during graded exercise. Five health subjects exercised on bicycle ergometer at three different loads (50, 70, and 100% of maximal oxygen uptake). Active plasma renin and plasma angiotensin II were elevated significantly during graded exercise, but plasma inactive renin decreased during the heaviest exercise; the mean ratio of active renin to total renin increased from 57 to 92% after the heaviest load. Plasma norepinephrine was also elevated during graded exercise. There is a positive correlation between plasma norepinephrine and active plasma renin during graded exercise (r = 0.916, p less than 0.01). Similar norepinephrine and active renin responses to graded exercise suggest that the mechanism(s) for activation of inactive renin and the release of active renin from the kidney may be partially related to sympathetic nervous system activity.

Adult↗
PubMed1982

Antitumor protective property of an isoprenoid antibiotic, ascofuranone.

Ascofuranone (AF) showed an antitumor protective effect on L-1210 leukemia when AF was administered once 7 days before tumor challenge. However, effect was not elicited when host mice were treated with AF simultaneously with tumor challenge. AF pretreatment on day 7, 5 and 3 before tumor challenge protected the host from the ascites form of S-180. AF also retarded tumor growth when administered once daily for 5 consecutive days 24 hours after transplantation, but antitumor effect was not seen with combined treatments before and after the transplantation. Similar results were noted with Ehrlich ascites carcinoma. AF treatment of normal mice enlarged the solid lymphoid organs without affecting body weight gain. The splenocytes derived from AF-treated mice lowered mitogenic response to phytohemagglutinin, while the mitogenic response to concanavalin A and lipopolysaccharide was unaffected.

Animals↗
PubMed1982

Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties.

A strain of actinomycetes, isolated from a soil sample, has produced a novel antibiotic (C11H14O2S) containing a unique thiolactone moiety in its molecule. On the basis of taxonomic studies the producing organism was identified as belonging to the genus Nocardia. The antibiotic, named thiolactomycin, exhibits a broad antibacterial spectrum and particularly potent activity against Salmonella, Serratia and Bacteroides. Furthermore, the acute toxicity is weak in experimental animals. These results indicate that thiolactomycin is distinct from other known antibiotics and represents a new type of antibiotic.

Anti-Bacterial Agents↗
PubMed1982

Cyanocycline A, a new antibiotic. Taxonomy of the producing organism, fermentation, isolation and characterization.

A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad spectrum antimicrobial and antitumor activity.

Animals↗