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Biomedical subjects

J V Soames

Publications and source records attributed to J V Soames.

At least 55 records · Page 3Linked to original sources

Meningioma--an unusual forehead swelling: a case report.

Meningiomas are rarely encountered by head and neck clinicians. This report describes a patient with a meningioma presenting uncommonly as a long-standing forehead mass with minimal symptoms. Investigation identified a large bifrontal meningioma with extra-cranial extension involving the right orbit and forehead. The literature is reviewed with particular reference to extra-cranial meningioma and the case is discussed.

Aged↗

Cytotoxicity studies of dental restorative materials using human periodontal ligament cells in vitro.

A model that simulates conditions of clinical practice in vivo and allows extended exposure of test cells to test substances, was evaluated in vitro by screening the toxicity of seven dental restorative cements. Millipore filter discs, 0.45 micron pore size, or preserved dentine slices were used as diffusion barriers between test cells and test substances. Cytotoxicity was assessed by estimating cell loss from monolayers and by evaluating cytopathic changes in cultured cells. After 24 h exposure to the test materials results were in general agreement with reported observations from similar studies. However, extended exposure to composite resins gave rise to severe cytotoxicity, which has not been reported previously. In addition, monitoring of cultures by inverted microscopy demonstrated attempts at recovery in damaged monolayers with viable cells migrating and proliferating into areas of earlier cell loss. This supports observations in vivo of transient pulpal injury associated with the corresponding materials.

Acrylic Resins↗

Cultural and morphological characteristics of human periodontal ligament cells in vitro.

Primary cell lines from explants of human periodontal ligament were established in vitro to assess their suitability as test cells in a biocompatibility assay. They were maintained over nine passages. The constituent fibroblast-like cells (F-cells) were monitored throughout by light and electron microscopy. Although F-cells from several different donors displayed stable and consistent growth characteristics, after the ninth subculture changes in the fine structure suggested that some cells were undergoing differentiation or senescence. It is therefore recommended that cells from earlier passages be used in in vitro biocompatibility assays.

Adolescent↗

Dental manifestations of autoimmune hypoparathyroidism.

The histopathologic changes in three permanent molars from two siblings with autoimmune hypoparathyroidism as part of candida endocrinopathy syndrome are described. These teeth developed after the diagnosis of hypoparathyroidism and while each subject was receiving vitamin D and calcium supplementation. The pathogenesis of the dental changes is unknown, but it is possible that parathormone may directly influence tooth development independent of its role in calcium and phosphorous homeostasis.

Adult↗

Ectopic salivary gland tissue in the palatine and lingual tonsil.

A case is reported of a child born with a developmental field defect of the first branchial arch in whom there was partial obstruction of the oropharynx by a horseshoe-shaped mass of what was thought to be tonsillar tissue. 'Tonsillectomy' was performed but histopathological examination of the excised specimens showed them to be almost entirely made up of salivary gland tissue.

Child, Preschool↗

Bony remodelling in an osteoma of the paranasal sinuses.

Osteoma is the commonest benign tumour of the paranasal sinuses (Handousa, 1952). A case of a large osteoma removed from the frontal and ethmoid sinuses is presented. Histopathological examination of this tumour revealed evidence of bony remodelling similar to that seen in Paget's disease which has not been previously reported. The pathological significance of this finding is discussed.

Aged↗

Juvenile xanthogranuloma of the oral cavity: a case report.

A 3 1/2-year-old girl presented with a symptomless lump on her tongue which had been present for 8 months. A provisional diagnosis of fibroepithelial polyp was made and no treatment was carried out. Six months later the lump had increased in size and it was excised. Histological examination led to a diagnosis of juvenile xanthogranuloma. One year later the lesion had not recurred.

Child, Preschool↗

Intramuscular haemangioma of the orbicularis oris muscle.

The intramuscular haemangioma is a relatively uncommon benign vascular tumour which accounts for less than 1% of all haemangiomas. It is a rare lesion in the orofacial muscles. A case is reported arising in the orbicularis oris muscle presenting in a 9-month-old child.

Diagnosis, Differential↗

Is 'lateral aberrant thyroid' always metastatic tumour?

It is now a widely held belief that so-called 'lateral aberrant thyroid' tissue actually represents a metastasis from a malignant tumour of the thyroid gland. A case is presented which suggests that this is not always true, and an extensive review of the relevant literature is discussed.

Adult↗

Cystic lymphangioma in the adult parotid.

Cystic lymphangioma is a congenital lesion which rarely presents in adult life and even less commonly arises within salivary tissue. We report the sudden appearance of a large cystic lymphangioma within the parotid gland of a young man and discuss the management of this rare condition.

Adult↗

An unusual case of regional odontodysplasia.

A case is presented of a 3-year-old child with regional odontodysplasia affecting all erupted and developing mandibular teeth. Maxillary teeth were unaffected. This pattern of distribution does not appear to have been reported previously and the extent of involvement poses problems for the long-term dental management of the patient.

Child, Preschool↗

Lichen sclerosus et atrophicus of the oral mucosa.

Lichen sclerosus et atrophicus (LSA) is a relatively uncommon dermatitis mainly affecting the vulva. Oral involvement appears to be rare. A case of oral LSA without concurrent genital or skin lesions in a patient with vitiligo and hyperthyroidism is described, together with a review of the literature.

Female↗

Oral hairy leukoplakia in an HIV-negative renal transplant patient.

A case of oral hairy leukoplakia presenting in an HIV-negative renal transplant recipient is described. The diagnosis was confirmed by identifying Epstein-Barr viral particles in the upper prickle cell layers of the epithelium by electron microscopy and by in situ DNA hybridisation.

DNA, Viral↗

Basal cell adenocarcinoma of the parotid gland.

A case of basal cell adenocarcinoma of the parotid gland is reported. Histologically it is to be distinguished from basal cell adenoma and adenoid cystic carcinoma. Clinically the presentation may appear benign. Surgical excision is the treatment of choice. The prognosis is uncertain because of lack of follow-up data.

Adenocarcinoma↗

Late development of a squamous carcinoma in a reconstructed pharynx.

We report a case in which a squamous cell carcinoma was found to have arisen from a delto-pectoral skin flap used in pharyngeal reconstruction. The flap had been forming a neo-pharynx for 24 years. No other signs of recurrent disease had developed in this period. This raises the possibility of tumour induction in heterotopic skin used for oropharyngeal reconstruction.

Carcinoma, Squamous Cell↗