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Biomedical subjects

J Tóth

Publications and source records attributed to J Tóth.

At least 91 records · Page 5Linked to original sources

Summation of unit potentials.

The analysis of the compound surface EMG records is directed to obtain information on the activity of motor units. The aim of this study is to contribute to the investigation of the processes taking place in the summation of different unit potentials. The experiments were performed on frog's nerve-muscle preparations. The nerves were stimulated separately and collectively with synchronous and asynchronous electrical impulses. The results obtained by the analysis of the action potentials recorded from the muscles demonstrate that the compound action potentials were brought about by the linear summation of unit potentials involved in the common response.

Action Potentials↗

Testicular-epididymal fusion abnormality in undescended testis.

In the course of 1195 operations, performed in children with cryptorchidism, the testes were studied for size, turgor and fusion with the epididymis. Inquiries were made into the reasons of fusion disorders which were conspicuously numerous. Attention is called to this not too familiar condition which seems to play an important role in the emergence of fertility disorders in men with congenital cryptorchidism.

Adolescent↗

Prognostic significance of residual disease after radiation therapy of stage III breast cancer.

239 Consecutive women with stage III carcinoma of the breast were treated by primary radiation therapy (RT) from 1977 to 1985. The response rate was 89%, the 5-year survival 40% and the local-regional tumor control (LTC) 59%. For the 27 non-responders, postirradiation chemotherapy was initiated but they died within 3 years. 105 Patients were subjected to mastectomy and axillary dissection after RT. In 107 cases, the RT was not followed by surgery. Systemic treatment consisted of hormonal therapy in both groups. The RT plus surgery group had better survival rate, 58% vs. 35% at 5 years. However, the incidence of less favorable cases was higher in the RT alone group. Histological findings in the operated group are analysed to determine prognostic significance of residual disease. No residual or only damaged microscopic disease was found in the breast in 36% of the cases. The axillary lymph nodes (ALN) were free of disease in 42% of the women. Patients with negative ALN after RT had significantly better 5-year survival (82% vs. 43%) and LTC (85% vs. 60%) rates. Decreased chest wall recurrence rate was associated with no residual or damaged microscopic disease in the breast (5% vs. 21%). The disease-free ALN were more common after 50-80 Gy telecobalt than after 40-50 Gy kV irradiation (51% vs. 33%). Primary tumor size (phi less than 5 cm vs. phi greater than 5 cm) had no significant impact on histological findings or on prognosis. Residual disease is mainly a marker of tumor-host relationship which indicates the biological aggressiveness of the disease.

Adult↗

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History, Ancient↗

States causing infertility in adulthood in children with undescended testis.

A total of 1386 operations for undescended testis was made in 1250 boys. In 774 of them an apparently intact testis and epididymis were found. In 612, such epididymal developmental abnormalities were detected which exclude or do not make possible the passage of sperms from these organs to the deferent duct. It is believed to be plausible that the large number of cases with infertility is due, also in individuals with a unilateral cryptorchidism, to the abnormal fusion of the epididymis in both testes.

Adolescent↗

Intraocular invasion of recurrent epibulbar malignant melanoma.

A case of a recurrent epibulbar naevus is presented; it underwent malignant transformation and subsequently invaded the eyeball. The tumour histologically was a predominantly epitheloid cell melanoma containing numerous histiocytes and degenerated tumour cells. Electron microscopy revealed rare special structures, e.g. annulated lamellae, tubuloreticular structures, pseudocrystals in huge mitochondria. Besides, invasion of tumour cells into a capillary could be shown.

Adult↗