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Biomedical subjects

J Sahel

Publications and source records attributed to J Sahel.

At least 181 records · Page 10Linked to original sources
PubMed1985

Citrate and calcium secretion in the pure human pancreatic juice of alcoholic and nonalcoholic men and of chronic pancreatitis patients.

Citrate, calcium and protein have been estimated in pure pancreatic juice after a secretin and a CCK injection in 4 patients presenting with alcoholic calcified pancreatitis (ACP), 10 controls without evidence of pancreatic disease, drinking more than 130 g alcohol/day, and 10 controls without evidence of pancreatic disease, drinking less than 20 g alcohol/day. Citrate is normally secreted in the pancreatic juice and this secretion increases in parallel with protein after CCK injection. Citrate secretion is significantly decreased in the two alcoholic groups. Calcium secretion is increased in the ACP, and reasons are presented to suggest that this may be due to lesions of the ducts. These modifications could play a role in the formation of pancreatic stones which are mostly built up of calcium carbonate.

Alcoholism↗
PubMed1985

[Pathology of the vitreoretinal interface].

This comprehensive review of vitreoretinal junction involvement in various diseases is classified according to the static and dynamic features of the pathology. Apart from hereditary conditions such as Wagner's and Stickler's diseases, juvenile retinoschisis etc., retino-vitreal adhesions in equatorial degeneration and either idiopathic or secondary epiretinal membranes are described. Vitreo-retinal caused either by trauma, by cellular contraction in epiretinal membranes or by posterior vitreous detachment may especially provoke peripheral retinal tears or macular involvement.

Eye Diseases↗
PubMed1985

[Evaluation of macular functional capacity by helium-neon laser interferometry].

We describe the principles of the measure of visual acuity by using the laser interference retinometer. Interference fringes are projected on the retina, with variation of direction and thickness varied, to study the functional capacity of the macula. This method is particularly useful in patients with cataracts, because it is much less influenced by the clarity of the media than Snellen chart listing. We give the results of a series of 122 eyes with cataract, comparing pre-operative laser acuity and post-operative Snellen visual acuity. The pre-operative interfermometric measure is possible in 77% of the cases, but in most cases of mature cataract or dense posterior subcapsular opacities, the patients do not discern any interference fringes. In immature cataracts according to other results of the literature, post-operative Snellen visual acuity reaches preoperative laser acuity in 60% of the cases, and is better in 29% of the cases. Clinical conditions such as macular degeneration, cystoid macular oedema, amblyopia, visual field cuts through fixation or myopic choroïdopathy, may make the interferometer test unreliable.

Cataract↗
PubMed1984

[Localized Caroli's disease associated with mucosecreting papillary adenocarcinoma. Value of hepatic resection].

A new case of carcinoma arising in Caroli's disease in a 48-year old male patient is reported. Since dilatation of the bile ducts was localized to the left lobe, left hepatectomy was performed. Histological examination showed that the tumour was a papillary mucoid adenocarcinoma. There was no recurrence of cholangitis while the patient survived. This case and a review of the literature shows that left hepatectomy suppresses repeated attacks of cholangitis in patients with Caroli's disease restricted to the left lobe, and that the incidence of carcinoma in Caroli's disease is higher than was formerly believed, which should encourage early surgical treatment when the disease is localized in the left lobe.

Adenocarcinoma, Mucinous↗
PubMed1984

Annular pancreas. Report of one case associated with acute pancreatitis and diagnosed by endoscopic retrograde pancreatography.

Diagnosis of annular pancreas is possible by endoscopic retrograde cholangiopancreatography (ERCP) only when the branch encircling the duodenum is connected to the pancreatic duct system. The authors report on a case of annular pancreas characterized by pain and relapsing acute pancreatitis secondary to the malformation. Attention is focused on both the importance of endoscopic retrograde cholangiopancreatography for diagnosing the congenital duct anomaly and the exceptional association of acute pancreatitis and an annular pancreas.

Acute Disease↗
PubMed1984

[Local fibrinolytic treatment in occlusions of the central retinal artery].

The effectiveness of thrombolytic agents used in local infusion has been demonstrated in the treatment of acute myocardial infarctions by several randomized trials. Thrombolytic therapy seems also to improve the prognosis of certain acute life-threatening brain stem strokes. Two cases of central retinal artery occlusion were treated with intracarotid urokinase injections. Visual acuity was improved in both cases in less than 24 hours, repermeation of the occluded vessels was observed 48 hours after the beginning of treatment. The limits of this kind of therapy are emphasized: there must be no contra-indication to the fibrinolytic agents, a delay shorter than 6 hours after the beginning of symptoms, a lack of arguments in favour of an embolism, and integrity of the carotid bifurcation. Surveillance in an intensive cares unit during the first days is required.

Adult↗
PubMed1984

[Recurrent acute pancreatitis, associated with pancreas divisum. Clinical study of 12 cases].

Sixty-three cases of pancreas divisum were diagnosed in a series of 2,800 endoscopic retrograde cholangiopancreatographies performed between 1976 and 1982. This anomaly was significantly associated with recurrent pancreatitis. Based on 12 cases in which the only possible causative factor of acute pancreatitis was pancreas divisum, the symptoms of this association are described. There were seven males and five females. Average age at the onset of symptoms was 35.3 +/- 12.4 years. Heavy to moderate consumption of alcohol was never found; protein and fat intakes were within normal ranges. All patients presented with acute recurrent pancreatitis, half of them having suffered three to five attacks. The duration of troubles ranged from 6 months to 14 years. In half of the cases the attacks did not last more than twelve hours and were of moderate intensity. Even in case of frequent attacks, no loss of weight was observed. These features are different from that of chronic calcifying pancreatitis. Ultrasonography showed the intrapancreatic course of the mesenteric vein and/or the appearance of two areas of different tonality in the pancreatic head in 58 p. 100 of cases. Endoscopic retrograde cholangiopancreatography was always able to make the diagnosis of pancreas divisum. After 7 endoscopic and 2 surgical sections of the minor papilla symptoms regressed completely in 4 cases and improved in 3 cases (follow-up 2 to 36 months).

Acute Disease↗
PubMed1983

Protein content of precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis.

Chronic calcifying pancreatitis is characterized by the formation of intraductal protein plugs or precipitates and calcified stones in ducts. Similar precipitates may be collected by endoscopic retrograde catheterization of the main pancreatic duct. They are present in the pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis. Protein analysis of these precipitates was performed to try to elucidate the mechanism of stone formation. Two protein fraction were separated by extraction of precipitates. One fraction was easily soluble in saline and contained a small amount of most of the proteins of pancreatic juice. The other fraction was soluble in citrate or ethylenediaminetetraacetate and contained a few proteins with close isoelectric points and identical molecular weight (13,500). These proteins showed immunological identity with the "stone protein" isolated from human pancreatic calculi. Our data demonstrate that the major citrate-soluble protein of precipitates in pancreatic juice is identical with "stone protein". They are strongly support the concept that this protein is the organic matrix of pancreatic stones. Different mechanisms are proposed to explain the phenomenon of protein precipitation that frequently occurs in alcoholic subjects and patients with chronic calcifying pancreatitis.

Alcoholism↗