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Biomedical subjects

J S Moore

Publications and source records attributed to J S Moore.

At least 109 records · Page 6Linked to original sources
PubMed1975

Radiation inactivation of rabbit muscle aldolase.

Pulse radiolysis and steady-state X-radiolysis have been used to investigate the radiation inactivation of aldolase from rabbit muscle. Both eaq-and OH readily react with aldolase, and contribute to inactivation. The radical anions (CNS)2-and (Br)2-react with aldolase at neutral pH. The progressive addition of alkali results in an increase in the second-order rate constants, with an apparent pK approximately 10 +/- 0-3, and with the formation of an unstable intermediate, lambdamax approximately 400 nm resembling a phenoxyl radical. Steady-state radiolysis in the presence of (CNS)2-and (Br)2- at alkaline pH results in increased aldolase inactivation, with a pK of enzyme inactivation similar to that observed for reaction of the radical anions. We propose that a reaction of the radical anoins with tyrosine residues accounts for the resultant inactivation.

Animals↗
PubMed1975

Intracranial tumors: correlation of angiography with dynamic radionuclide studies.

In a group of 100 supratentorial brain tumors, 23% demonstrated increased activity during the dynamic portion of the brain scan. Increased activity correlates best with the following angiographic characteristics: (a) increased size of supplying vessels, and (b) vascular supply simultaneously from both parenchymal and meningeal arteries. Increased activity has no correlation with the presence of early venous drainage, peritumoral edema, or degree of tumor vascularity and/or stain.

Brain Neoplasms↗
PubMed1969

Pulse-radiolysis and spectral studies of the interaction of cetylpyridinium chloride and methylene blue with connective-tissue glycosaminoglycans and related compounds.

1. Hydrated electrons produced by pulse radiolysis were used to study the interaction of polyanionic glycosaminoglycans and related compounds with the counterions Methylene Blue and cetylpyridinium chloride. 2. The effect of added salt (potassium chloride) on the interaction indicates that the relative binding affinities, with respect to the types of anionic site present, increases for both counterions in the order CO(2) (-)<CO(2) (-)+O.SO(3) (-)<CO(2) (-)+O.SO(3) (-) +N.SO(3) (-)<O.SO(3) (-). The interactions of the polyanions with cetylpyridinium chloride are considerably stronger than those with Methylene Blue. 3. The effects of added salt on the metachromasia resulting from polyanion-Methylene Blue interaction were examined spectrophotometrically. 4. The collective results demonstrate a direct relationship between anionic site-dye binding and metachromasia, although a residual dye binding can be detected by pulse radiolysis when metachromasia is completely removed.

Binding Sites↗