Hearts lacking donor-type APCs develop cardiac allograft vasculopathy.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
J S Moore
Publications and source records attributed to J S Moore.
Tolerance of rat cardiac allografts does not require donor-type "passenger" antigen presenting cells.
Explore the source record for details and available documents.
Animals↗
Use of ESR for the detection of irradiated dates (Phoenix dactylifera L.).
One variety (Aple) of Libyan dry dates (Phoenix dactylifera L.) was irradiated in a 60Co source to absorbed doses of 0.8, 1.0, 1.5 and 2.0 kGy. Unirradiated date stone contains a radical with a single line g = 2.0045, feature A. Irradiation to a dose of 2.0 kGy (the recommended dose for fruits in U.K.) induces the formation of additional radicals with signals g = 1.9895 and 2.0159, feature C. The single line having g = 2.0045 decays in both unirradiated and irradiated samples whereas the additional signals g = 1.9895 and 2.0159 remain almost unchanged over a period of time 15 months stored at room temperature and 4 degrees C.
Electron Spin Resonance Spectroscopy↗
Folding-driven synthesis of oligomers.
The biological function of biomacromolecules such as DNA and enzymes depends on their ability to perform and control molecular association, catalysis, self-replication or other chemical processes. In the case of proteins in particular, the dependence of these functions on the three-dimensional protein conformation is long known and has inspired the development of synthetic oligomers and polymers with the capacity to fold in a controlled manner, but it remains challenging to design these so-called 'foldamers' so that they are capable of inducing or controlling chemical processes and interactions. Here we show that the stability gained from folding can be used to control the synthesis of oligomers from short chain segments reversibly ligated through an imine metathesis reaction. That is, folding shifts the ligation equilibrium in favour of conformationally ordered sequences, so that oligomers having the most stable solution structures form preferentially. Crystallization has previously been used to shift an equilibrium in order to indirectly influence the synthesis of small molecules, but the present approach to selectively prepare macromolecules with stable conformations directly connects folding and synthesis, emphasizing molecular function rather than structure in polymer synthesis.
Biopolymers↗
Mycobacterial contamination of metalworking fluids: involvement of a possible new taxon of rapidly growing mycobacteria.
Contamination of air and metalworking fluid (MWF) systems with a rapidly growing mycobacterium (RGM) was detected in 1995 in a single manufacturing plant with recent cases of hypersensitivity pneumonitis (HP). Extensive environmental sampling was performed to determine the extent of the contamination and its variability over time. RGM were present in multiple indoor air samples, 100% of the central MWF storage tanks, and 75% of the freestanding cutting, drilling, and grinding machines. With one exception, contamination was limited to a recently introduced formulation (brand) of semisynthetic MWF used in 95% of the facility's machining operations. In general, the mycobacterial counts were stable over time, with the degree of contamination ranging from 10(2)-10(7) colony forming units (CFU)/mL. A few systems were culture positive for the mycobacterium (> 10(1) CFU/mL), changed to culture negative (< 10(1) CFU/mL), then changed back to culture positive without explanation. Samples obtained from diluted (5%) but unused MWF, a replenishment line with 2% unused MWF, an MWF pasteurizer, city water, and deionized water were culture negative for this species of mycobacterium. Inoculation and growth studies demonstrated that this mycobacterium does not grow in liquid samples of 5% unused MWF. By molecular techniques, the mycobacterial isolates consisted of a single strain and represented a previously undescribed taxon closely related to Mycobacterium chelonae/abscessus. The relationship of this mycobacterium to the cases of HP is unknown.
Air Microbiology↗
Validity of generic risk factors and the strain index for predicting nontraumatic distal upper extremity morbidity.
Nine individual generic risk factors, eight combinations of generic risk factors, the presence of any generic risk factor, and the Strain Index were evaluated for 56 jobs by 2 evaluators blinded to morbidity measures. Jobs then were assigned to dichotomous hazard classifications (problem versus safe) according to recommendations from the literature. OSHA 200 logs were used to ascertain historical evidence of distal upper extremity (DUE) morbidity, and jobs were assigned to a dichotomous morbidity classification (positive versus negative) using none versus one or more recorded cases as the criterion. Evidence of association and measures of predictive validity were evaluated by comparing hazard and morbidity classifications using 2 x 2 contingency tables. Five individual generic risk factors, three generic risk factor combinations, and the presence of any generic risk factor were not associated with morbidity classification. The odds ratio estimates among the four individual generic risk factors and the five combinations of generic risk factors associated with DUE morbidity varied from 3.3-36.0. The Strain Index had the largest estimated odds ratio of any exposure factor at 108.3. The exposure methods were grouped according to patterns of predictive validity. With one exception, the individual generic risk factors and their combinations had high sensitivity with low specificity (many false-positives), low sensitivity with high specificity (many false-negatives), or low sensitivity with low specificity. The only generic risk factor that demonstrated reasonable predictive validity was the use of gloves--its sensitivity, specificity, positive predictive value, and negative predictive value were equal to 0.75. The Strain Index performed better than any of the individual or combinations of generic risk factors. Its sensitivity, specificity, positive predictive value, and negative predictive value were all approximately 0.90.
Arm↗
Epidemiology of low-back pain in industry.
Low-back pain and back injuries are of such a complex nature that any one criterion cannot be applied by itself to give a valid assessment of the risk associated with manual materials-handling jobs. There is no question that low-back pain is an extremely significant cause of disability and has a major socioeconomic impact, but many different personal and job factors are associated with the incidence and prevalence of these complaints. There is a need for ongoing systematic investigations of the multiple risk factors that may be causally related to low-back pain and may possibly be amendable to preventive interventions. Knowledge of workplace and individual risk factors is far from complete. Prospective studies are needed so that factors contributing to the development of low-back pain can be separated from factors resulting from low-back pain. It is difficult to relate low-back pain to the workplace because it occurs quite often in workers employed in sedentary occupations. However, incidence, severity, and disability are all related to the physical demands of the job. In this regard, jobs involving lifting, lowering, pushing, pulling, carrying, and holding; body movements such as frequent bending, twisting, and sudden movements; and working in bent-over postures appear to have a significant potential for producing low-back pain. A combination of lifting, bending, and twisting appears to be most hazardous. It is concluded that lifting heavy loads contributes to increased frequency and severity rates for low-back pain. This is true regardless of whether the lifting is performed over a short period or throughout the day and whether it is performed a few times per day of repetitively. If, however, such lifting is performed repetitively, the medical hazard extends beyond low-back problems to other musculoskeletal strain and sprain injuries and to fatigue-related injuries, particularly for weaker workers. In this latter regard, gender, age, anthropometry, and previous history of back pain are known to modify these risks for populations of workers. The inherent variability between workers and within any worker over time precludes the use of such factors to assign risk to any particular individual.
Female↗
Prevention strategies and the low back in industry.
Several different approaches have been tried in industry to prevent low-back injuries. The scientific literature shows that only job-specific strength testing and ergonomic job design are partially effective in preventing low-back injuries. Job-specific strength testing is supported as a means of identifying high-risk workers who need to perform manual materials handling. However, this approach should be carefully validated for its effectiveness before it is used as a form of selection procedure. At present, ergonomic job design offers the most potential for preventing disabling low-back injuries and other musculoskeletal injuries. Quantitative and objective methods (such as NIOSH guidelines, biomechanical models, energy expenditure, and strength data) are available to analyze a given job and to determine the relative risk of an injury.
Ergonomics↗
Function, structure, and responses of components of the muscle-tendon unit.
A "muscle-tendon unit" is a composite structure that includes muscle, tendon, myotendon junctions, tendon sheaths, and tendon-bone junctions. Each component is unique in its structure, function, response to strain, and associated clinical disorders (usually called "tendinitis"). Tendinitis implies localized tenderness in the distribution of a muscle-tendon unit to palpation, passive stretching, or active contraction. A variety of distinct clinical entities associated with the various components of the muscle-tendon unit are usually grouped together under the term "tendinitis," although each has unique characteristics and etiologic factors. Most have short latencies and favorable prognoses with appropriate clinical management, and most also bear some direct relationship to biomechanical factors, such as compression or strain, as well as to work organizational factors, particularly unaccustomed work.
Elasticity↗
Carpal tunnel syndrome.
Despite numerous publications in the literature, there is still a significant deficit of knowledge regarding carpal tunnel syndrome and its relationship to work. This chapter reviews a variety of observations from these studies. Epidemiologic studies have been mostly cross-sectional surveys using clinical criteria (symptoms and physical findings) as a basis for case definition, but these exposure assessments cannot discriminate between work-related and non-work-related cases of carpal tunnel syndrome. These studies do reveal a fairly consistent pattern of observations regarding the spectrum and relative frequency of upper extremity morbidity among jobs believed to be hazardous. Carpal tunnel syndrome, however, is but one of these disorders and is not the most common one. Historical perspectives, anatomic pathology, pathophysiology, theories of pathogenesis, epidemiologic observations, associations with exposure, and current issues are discussed.
Animals↗
Sexual initiation with older male partners and subsequent HIV risk behavior among female adolescents.
Data from a 1993-1994 survey of 150 black and Hispanic teenagers were used to examine differences in HIV risk-related behavior between young women who have a first sexual partner three or more years older than themselves and those whose first partner is their age. Compared with teenagers whose first partner had been roughly their age, the 35% of adolescents with an older partner had been younger at first intercourse (13.8 years vs. 14.6) and less likely to use a condom at first intercourse (63% vs. 82%). They also were less likely to report having used a condom at last intercourse (29% vs. 44%) or having used condoms consistently over their lifetime (37% vs. 56%) or in the previous six months (44% vs. 66%). Some 38% of teenagers with an older first partner had ever been pregnant, compared with 12% of those with a peer-age first partner. The mean number of partners and history of sexually transmitted diseases did not differ between the two groups.
Adolescent↗