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Biomedical subjects

J Pearce

Publications and source records attributed to J Pearce.

At least 73 records · Page 4Linked to original sources
PubMed1975

The effects of choline and inositol on hepatic lipid metabolism and the incidence of the fatty liver and kidney syndrome in broilers.

1. Diets high in wheat and low in protein (18%) produced 5 to 6% mortality from fatty liver and kidney syndrome (FLKS) in broiler chicks whereas there were no deaths from FLKS in birds fed on a maize/barley diet containing 20% protein. 2. Supplementation of the wheat-based diets with choline or inositol (2-5 g additive/kg diet) did not affect the incidence of FLKS or liver lipid metabolism. 3. The wheat-based diet did not significantly affect the activities of hepatic lipogenic enzymes suggesting that hepatic lipid biosynthesis is not a cause of the syndrome. 4. The biotin contents of the wheat and maize/barley diets were little different, which may suggest that factors other than this are implicated in FLKS.

ATP Citrate (pro-S)-Lyase↗
PubMed1974

Blood sugar response to glucagon in migraine.

The hyperglycaemic response to intramuscular glucagon was studied in 19 migraine subjects and 17 matched controls. Venous blood sugar 30 minutes after the injection, and the maximum rise from fasting levels, were significantly reduced in migraine subjects. This diminished sensitivity to the hyperglycaemic action of glucagon may be at least one factor in the hypoglycaemia unresponsiveness shown in migraine.

Adult↗
PubMed1973

Neuropathy of metachromatic leucodystrophy.

We describe two patients with metachromatic leucodystrophy who presented with peripheral neuropathy and had no evidence of central nervous system involvement at the time of presentation. Such an occurrence is not well recognized and the diagnosis is usually missed until the other features of the disease manifest themselves. Early recognition of this disease may become of practical importance from the point of view of therapy, judging from recent developments, and is also important from the point of view of genetic counselling. We suggest that cases of peripheral neuropathy in infancy and childhood, should be subjected to peripheral nerve biopsy when the aetiology is not obvious.

Biopsy↗