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Biomedical subjects

J Pearce

Publications and source records attributed to J Pearce.

At least 91 records · Page 5Linked to original sources

Comparative and serial assays of folate metabolism in anticonvulsant-treated epileptics.

A prospective study of folate metabolism has been conducted in outpatient anticonvulsant-treated epileptics on 68 occasions. An attempt was made to compare the relative sensitivities of serum and red cell measurements of folic acid, lactic dehydrogenase (LD), and 2 hydroxybutyric dehydrogenase (2HBD). The most sensitive indices of folate deficiency appeared to be serum folate, red cell LD, red cell folate, and red cell 2HBD, respectively. The correlation between these measurements was not close, except in comparisons of red cell and serum folate. No easily performed screening test for folate deficiency emerged. Serial changes in these measurements were carried out on 15 patients during an interval of 18 months. No progressive signs of folate depletion appeared during this time. The significance of these findings is discussed.

Adolescent

Medical interviews.

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Appointments and Schedules

An investigation of lipogenic and glycolytic enzyme activity in the liver of sexually immature and mature domestic fowl.

In the non-laying pullet and the cockerel it was observed that there was no significant variation in the activities of ATP citrate lyase and ;malic' enzyme whereas in the laying hen there was a significantly greater activity of both these enzymes. Parallel increases in liver lipid content in the laying hen were also observed. Three glycolytic enzymes, phosphofructokinase, fructose diphosphate aldolase and pyruvate kinase, did not exhibit any significant variation in enzyme activity with the onset of egg laying. These results are discussed in relation to the hormonal status of the birds and also the demands of egg production for lipid.

Aldehyde-Lyases

Insulin induced hypoglycaemia in migraine.

Insulin induced hypoglycaemia produced migrainous symptoms in only two of 20 migraine sufferers and in none of a matched control group. The relationship of fasting and blood sugar levels to migraine attacks is discussed.

Adult