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Biomedical subjects

J Palou

Publications and source records attributed to J Palou.

At least 127 records · Page 7Linked to original sources
PubMed1985

Painful subungual keratotic tumors in incontinentia pigmenti.

We report a case of dyskeratotic subungual tumor in a 28-year-old woman. The patient presented achromic lineal lesions, typical of residual incontinentia pigmenti (IP), on her legs. Furthermore, the physical examination showed anodontia of the right incisor tooth. The familial background demonstrated miscarriages of male fetuses and characteristic dental abnormalities of IP in female siblings. The patient's daughter presented a typical background of IP and dyschromic splashed lesions. Light and electron microscopic studies of the subungual tumors were made. The analogy between subungual tumors of IP and keratoacanthoma is emphasized.

Abnormalities, Multiple↗
PubMed1985

Comparative study of the interactions AMP-phosphorylase b and AMP analogues-phosphorylase b.

The different effects induced by AMP and its analogues on the tertiary structure and the coenzyme environment of phosphorylase b were studied by titration of the slowly reacting thiol groups and by quenching of the coenzyme fluorescence, respectively, to determine the possible differences that activate phosphorylase b. The following results were obtained: The coenzyme environment depends upon the nucleotide studied. AMP, when bound to its first site, opens the coenzyme pocket. The slow cysteines were shielded by the nucleotides against their DTNB titration depending on the nucleotide studied. The enzyme difference spectra in presence of the nucleotide showed that the negative band of 260 nm is similar for all nucleotides possessing the same base, but the positive band obtained in the presence of AMP was diminished when other nucleotides were present.

Adenosine Monophosphate↗
PubMed1984

[Multiple clear-cell acanthoma].

Clear cell acanthoma is a benign tumor reported by Degos et al. in 1962. Most commonly the acanthoma presents as a solitary nodule on the lower limb in late middle-aged persons. We've found only 11 papers about multiple clear cell acanthoma. We describe a 73 years old patient who had 21 lesions, the highest number found in the literature.

Aged↗
PubMed1983

[Eruptive vellus cysts. Report of 2 cases].

Two cases of eruptive vellus hair cysts (EVHC) are reported. In the second case the clinical diagnosis of EVHC was made. The authors believe that the clinical features may permit the clinical diagnosis of EVHC.

Adult↗
PubMed1983

[Cutaneous myelofibrosis].

A case of myelofibrosis with papulonodular cutaneous lesions in a 49 year old man is reported. The histopathological studies showed the presence of the three hematopoietic lines in the skin lesions, which is a uncommon feature.

Hematopoietic Stem Cells↗
PubMed1983

[Polypoid pseudosarcoma of the tongue].

Polypoid pseudosarcoma (PP) is a rare type of squamous-cell carcinoma of mouth, fauces and larynx with sarcoma-like reaction. Clinically PP is characterized by large pedunculated or sessile masses of rapid growing. This tumour recurs easily but rarely provokes metastasis. A case of polypoid pseudosarcoma of the tongue is reported. Differential diagnosis with spindle-cell carcinoma can be made following the criteria: a) the frequency and the sarcomatous appearance of the metastasis in the spindle-cell carcinoma, while PP rarely provokes metastasis which have a squamous-cell pattern; b) the gradual transition within the epithelial and the sarcomatous aspects in the spindle-cell carcinoma, not present in PP; and c) the presence of tonofilaments and desmosomes in the sarcomatous cells of the spindle-cell carcinoma, which lack in the sarcoma-like masses of PP.

Aged↗
PubMed1981

Histopathology of the saburral tongue.

Optical microscopical studies were carried out on biopsies from 22 patients affected by saburral tongue (ST). The histopathological pattern consisted of a papillomatous acanthosis covered with a very thick horny layer. Abundant colonies of banal germs were seen in the keratin. There was an alternation of suprapapillary orthokeratosis and interpapillary parakeratosis. Under the keratin layer all the keratinocytes were large and clear with a glycogen-filled cytoplasm. Two specimens, studied with a transmission electron microscope, only showed that the keratinocytes were filled with glycogen. The clear glycogen-filled epithelial cells are common either in normal lingual epithelium or in some pathological conditions. The microscopic field of ST is quite similar to that of the hairy black tongue; but these peculiar clinical aspects of the tongue do not evolve one through the other.

Adult↗
PubMed1981

[Multiple eccrine-pilar hamartoma].

Two cases with acquired lesions on the face and tendency to spread are reported. The unusual lesions have the appearance between millium and atrophodermia vermiculate and the histology presents features of syringoma and trichoepithelioma making this hamartoma unclassifiable. Cases with similar characteristics are discussed.

Adult↗
PubMed1981

[Proliferating trichilemmal cyst. Apropos of a case].

Malignant change in some keratinous cysts is a possible but rare condition. It seems acceptable that many publications concerning squamous cell carcinomas arising from previous cysts, actually correspond to the entity which Wilson-Jones called "proliferating epidermoid cyst" and they must be considered as pseudomalignant lesions, despite the presence of some features that may lead to a diagnosis of carcinoma. Although it is rare, which is nowadays called "proliferating Trichilemmal cyst", should be widely acknowledged since its misdiagnosis as squamous cell carcinoma leads to surgical treatment which is more drastic than necessary. Herein is presented an unusually situated case of proliferating Trichilemmal cyst and a review of the principal characteristics that have been pointed out in this tumor.

Carcinoma, Squamous Cell↗
PubMed1980

Acute and chronic graft-vs-host reaction in skin: report of two cases.

The cutaneous changes of the acute form of graft-vs-host reaction are described in two patients who underwent bone marrow transplantation for treatment of severe aplastic anaemia. One patient went on to develop a chronic reaction of the lichenoid type. Histopathology confirmed the presence of 'satellite cell necrosis' from the acute stage of the disease onwards. Direct immunofluorescence showed deposits of immunoglobulin (IgG, IgM), fibrinogen and complement on the necrotic keratinocytes, whilst the basement membrane was positive for C3. These findings suggest that humoral immunity as well as cellular immunity may play a part in the production of the rash.

Acute Disease↗
PubMed1980

Ultrastructural findings in acute and chronic graft-vs-hos reaction of the skin.

Two cases of graft-vs-host reaction (GVHR) after allogeneic bone marrow transplantation were studied by transmission electron microscopy. One was observed only in the acute phase and the other, after a mild acute reaction, showed a chronic lichen planus-like pattern. All types of skin damage described in experimental GVHR have been confirmed in both cases. Our findings indicate an involvement of aggressor lymphocytes against keratinocytes as the chief pathogenetic mechanism of the disease, even in its chronic form, although the participation of humoral factors in some phases of the disorder cannot be excluded. The participation of Langerhans cells and macrophages in the reaction could not be demonstrated in these cases.

Acantholysis↗