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Biomedical subjects

J Nagy

Publications and source records attributed to J Nagy.

At least 163 records · Page 9Linked to original sources
PubMed1986

A chart review of schizotypal personality disorders in children.

The objectives of this paper are to review the literature on the diagnostic validity of schizotypal personality disorders (SPD) in childhood and to present the results of a chart review of 20 DMS-III-defined SPD children. The literature on this disorder is relatively limited, and although there is some agreement on clinical presentation, various authors have used different diagnostic labels. The DSM-III criteria for SPD appear to have acceptable content validity, but whether these are the best criteria for identifying a disorder with a particular etiology and natural history has not been investigated. The chart review on 20 SPD children presents information on early history, family background, neurodevelopmental impairments, and the degree of overlap with other, better-established diagnoses. On the basis of the chart review, suggestions for further research on the diagnostic validity of SPD are made.

Adolescent↗
PubMed1986

Fixed interval performance in weanling rats: a comparison with adult and senile subjects.

Weanling (21 days), adult (100 days) and senescent (26 months) albino rats were submitted for 8 days to a fixed interval 60 second schedule, at a pace of 5 half-hour sessions a day. Temporal regulation indices (Curvature Index of Fry, Kelleher and Cook), overall response rates and running rates depend upon the age of the subjects and rank orderly (weanling greater than adult greater than senile). No significant difference was found for post-reinforcement pause durations. Two weeks after the end of the FI 60 second sessions, the senile subjects were submitted to a FI 120 second schedule for 10 days. The inverse relationship between age and temporal regulation accuracy evidenced in FI 60 seconds is discussed in relationship with classical FI data, factors involved in developmental studies and models for time regulated behavior.

Aging↗
PubMed1985

Differentiation of glomerular and non-glomerular haematurias on basis of the morphology of urinary red blood cells.

Haematurias present serious problems in differential diagnostics. Although no clear-cut instructions exist, patients with haematuria are usually directed to urological surgeries or inpatient departments. Here they are routinely checked by a number of invasive techniques (cystoscopy, i. v. urography, aortography etc.) before the urological nature of haematuria can be ruled out. The suspicion of a glomerular disease being in the background of haematuria emerges only if it is accompanied by a marked proteinuria. Our department deals with kidney diseases since decades. The routine light microscopic examination of haematuric urinary samples called attention to the fine differences between erythrocyte morphology in glomerular and other haematurias. The present paper is an account of morphological studies of red blood cells carried out in haematuric urinary samples of 120 histologically verified glomerulonephritis and 80 other cases.

Diagnosis, Differential↗
PubMed1985

Recrystallization from ether causes unusual changes in the convulsant activity of pentylenetetrazol.

The convulsant activity of commercial pentylenetetrazol (PTZ) and that of pentylenetetrazol recrystallized from ether (PTZE) were compared in the waking rabbit by means of recording the electrical activity of the brain. In addition, the interaction between the two substances was studied. When given in slow intravenous infusion, PTZE proved only half as effective as PTZ (threshold doses: 23.18 +/- 1.8 mg/kg and 12.40 +/- 0.7 mg/kg, respectively). One single infusion of PTZE 5-10 days prior to the administration of PTZ decreased the latter's convulsant activity to half of the original, while PTZ pretreatment left the activity of PTZE unaltered. Previous physico-chemical investigations suggested that, after recrystallization from ether the molecule might be present in dimer form at the phase-boundaries. Such a process, if taking place also at the cell membrane surface might account for the diminished convulsant activity of the recrystallized molecule.

Animals↗
PubMed1984

Molecular weight measurement of human satietin.

Attempts were made to estimate the actual molecular weight of satietin, an endogenous food intake inhibitor, by means of classical and high-performance gel filtration and gel electrophoresis. Satietin, which proved to be a glycoprotein, was isolated from human plasma. Sephacryl S-300 gel and TSK-GEL G 3000 SW columns were used as media for gel filtration and gel electrophoresis in the presence of sodium dodecyl sulphate (SDS-PAGE), respectively. A relatively good correlation was established between the molecular weight measurements carried out by different methods, although satietin as a carbohydrate-rich glycoprotein gave an underestimated value by gel filtration when the calibration graphs were constructed with simple proteins. The molecular weight of satietin was determined to be about 43,000 daltons by SDS-PAGE and 29,000 daltons by gel filtration when using a buffer containing 1% of sodium dodecyl sulphate.

Chromatography, Gel↗
PubMed1984

Cu2+ is the active principle of an endogenous substance from porcine cerebral cortex which antagonizes the anticonvulsant effect of diazepam.

A boiled extract of porcine cerebral cortex was fractionated on Sephadex G-75 and LH-20 followed by paper chromatography of the active fraction having inhibitory activity towards [3H]GABA binding to rat brain synaptic membranes. A ninhydrin-negative substance migrating more quickly than authentic GABA was identified as a copper-GABA complex. The complex inhibited specific [3H]GABA binding (IC50 approximately equal to 1 microM) and antagonized the anticonvulsant effect exerted by intraamygdaloid injection of diazepam. The effect of a synthetic copper-GABA complex was compared and found to be similar to the endogenous complex. Cu2+ alone has no affinity for the GABA recognition site but antagonizes the anticonvulsant effect of diazepam. Therefore, Cu2+ is suggested to be the pharmacologically active principle of the endogenous substance. Cu2+ does not seem to function via the recognition site of the GABA receptor.

Amygdala↗
PubMed1984

The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis.

The authors investigated the tubulointerstitial changes (atrophic tubuli, interstitial fibrosis and round-cell infiltration) by two methods in renal biopsies from 56 patients with IgA glomerulonephritis. A statistically significant correlation was found to exist between the tubulointerstitial changes and serum creatinine level at the time of renal biopsy. A statistical significant correlation was also established between serum creatinine at the end of a period of 5 years of follow-up and tubulointerstitial changes. Their results suggest that severe tubulointerstitial lesions in IgA glomerulonephritis carry a poor prognosis.

Adolescent↗
PubMed1984

Herpes virus antigens and antibodies in kidney biopsies and sera of IgA glomerulonephritic patients.

Antibody titers against 4 viruses of the herpes group have been studied in the sera of 54 patients with IgA glomerulonephritis (GN). The incidence of antibodies to herpes simplex virus type-1 (HSV-1), HSV-2, cytomegalovirus (CMV), Epstein-Barr virus nuclear antigen (EBNA), and that of IgG antibodies to EBV virus capsid antigen (VCA) were similar in patients and in controls. However, elevated antibody titers (greater than or equal to 64) to HSV and CMV occurred more frequently in patients with IgA GN than in healthy controls. Geometric mean titers to HSV and CMV were also higher in patients suffering from IgA GN than in controls. The incidence of IgA antibodies to EBV VCA occurred in patients with IgA GN significantly more often than in controls. There was a trace amount of HSV-2 antigen in 2 glomeruli of 1 renal biopsy. It is concluded that, in some patients with IgA GN, there is an abnormal immune response to certain types of herpes viruses.

Adolescent↗
PubMed1984

IgA glomerulonephritis: light microscopic and immunohistological studies.

Renal biopsy material of 50 patients suffering from IgA glomerulonephritis was studied by light microscopy, immunofluorescence and occasionally electron microscopy. Associated with a uniform immunohistological pattern mainly focal or diffuse mesangial proliferative glomerulonephritis was found. In addition to the glomerular changes the importance of frequent extraglomerular, mainly vascular and interstitial, alterations is stressed. In arterioles and arteries, deposition of a hyalinous substance was observed. Immunohistology revealed the presence of immunoglobulins and/or C3 in the vessels. In the interstitium fibrinogen/fibrin was often seen, accompanied by chronic inflammatory infiltration and fibrosis.

Arteries↗
PubMed1984

Plasmapheresis and peritoneal dialysis in the management of rapidly progressive glomerulonephritis.

Six patients with rapidly progressive glomerulonephritis were given plasmapheresis and peritoneal dialysis by manual technique. At the start of treatment the patients were in renal failure and all but two were practically anuric. Renal biopsy revealed glomerular sclerosis in 4 cases. One of the patients in whom segmental focal fibrosis was found, went into remission. In the other three cases extensive hyaline degeneration was present. One of them was placed on a dialysis program, two died with circulatory failure. In two cases no glomerular sclerosis was found, though extensive changes of the tissues were present. One of these patients went into remission, the other died from respiratory failure consequent upon recurrent pneumothorax and gross pulmonary infiltration. The only chance of success in the management of rapidly progressive glomerulonephritis is offered by the earliest possible diagnosis. In cases of glomerular sclerosis the chances are very poor.

Adult↗