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Biomedical subjects

J Nagy

Publications and source records attributed to J Nagy.

At least 181 records · Page 10Linked to original sources
PubMed1982

Circulating immune complexes in patients with IgA glomerulonephritis.

Fourty-four patients with IgA-glomerulonephritis (IgA GN) were studied for circulating immune complexes (IC) repeatedly in the course of disease on the evidence of four different methods suited for the detection of IC, viz. complement consumption assay, Clq-solubility test and two tests based on PEG-precipitation, and of indirect signs pointing to the presence of IC. Joint assessment of the direct and indirect signs (positivity of a minimum of 2 indirect signs or any of the direct signs) permitted to ascertain the presence of circulating IC in 72 per cent of the patients and in 63.3 per cent of the examined sera. There was no close relationship between the presence of IC and the clinical activity. On the other hand, in 16 patients positive for the rheumatoid factor (RF) the renal biopsy material revealed extensive vascular lesions. The findings suggest that the circulating IC, some of which contain RF, play a part in the pathomechanism of IgA GN and are involved in the production of the vascular abnormalities in this disease.

Adolescent↗
PubMed1982

An improved method for the preparation of highly purified satietin samples from human serum.

Satietin, a highly selective anorectic substance, was prepared in highly purified form. A new isolation procedure is described for the preparation of human satietin. Serum proteins were removed by ultrafiltration and precipitation with trichloroacetic acid and the satietin active substances were then separated by gelchromatographic and electrophoretic techniques. The highly purified materials are proved to show carbohydrate properties. The carbohydrate and protein content of samples were determined by amino acid and sugar analysis after acid hydrolysis of samples. According to a specific bioassay these substances were found to contain 100 units/mg activity, and concluded to be glycoproteins having molecular weight around of 50,000.

Amino Acids↗
PubMed1982

Clinical features and course of IgA glomerulonephritis.

A review of the clinical features, laboratory findings and course in 50 cases of IgA glomerulonephritis confirmed by biopsy is presented. The onset and clinical course of the process was oligosymptomatic in the majority of the cases with a predominance of microhematuria and persistent proteinuria. By the end of the observation period more than 50 per cent of the patients became hypertensive and in 16 cases serum creatinine levels attained 132 mumol/l (1.5 mg per 100 ml) or more. Proteinuria in excess of 1 g/24h, hypertension and an impaired concentration capacity at the onset heralded early progression.

Adolescent↗
PubMed1981

Cholinergic and catecholaminergic interaction and fluid intake in the rat.

The effect of simultaneous topical application of adrenergic agonists was investigated on the polydipsia caused by direct carbachol (CCh) stimulation of the rat brain. In addition, fluid selection (4-choice arrangement) was studied. Noradrenaline and isoprenaline fully antagonized the CCh effect after either intracerebroventricular, intraseptal or intrapreoptic application. Phenylephrine inhibited CCh polydipsia after intracerebroventricular or intrahypothalamic but not after intraseptal injection. Previous experiments had shown that adrenergic agonists also exerted a marked modulatory influence on an affective behavioural reaction pattern (rage reaction) of the cat. The results of the present experiments corroborate the assumption that, also in non-striatal brain structures, adrenergic modulation of cholinergic behavioural patterns is perhaps a more general and important phenomenon than had been assumed so far.

Adrenergic Agonists↗
PubMed1981

Wegener's granulomatosis exhibiting the clinical features of Goodpasture's syndrome.

A case is reported here, the clinical features of which raised the suspicion of Goodpasture's syndrome which was, however, at variance with the absence of antiglomerular basement membrane antibodies. Renal failure improved on immunosuppressive treatment and peritoneal dialysis, but the patient died of gastric haemorrhage from a peptic ulcer related to steroid treatment. Necropsy and microscopic study revealed abnormalities of liver and spleen, consistent with Wegener's granulomatosis. Immunohistologic studies of the kidney confirmed the presence of granular-type IgG deposits in the glomeruli. There were extensive fibrin deposits in the kidney. The ways and means for the differentiation of Wegener's granulomatosis from Goodpasture's syndrome, the potential pathogenetic role of immunocomplexes and fibrin deposits, and the therapeutic possibilities are discussed.

Anti-Glomerular Basement Membrane Disease↗
PubMed1979

IgA glomerulonephritis. Mesangial IgA deposition without systemic signs (Berger's disease).

Renal biopsy specimens from 204 patients with glomerulonephritis or nephrotic syndrome have been studied. In ten of the patients not suffering from acute poststreptococcal glomerulonephritis, systemic lupus erythematosus or Schönlein-Henoch syndrome, diffuse, selective mesangial IgA deposition was observed. Clinically, persistent microscopic haematuria, mild proteinuria and, except in one patient, normal renal function were found. Light microscopically the histological picture was dominated by a diffuse or focal increase in volume of the mesangial matrix, and mild mesangial cell proliferation. Exceptionally, there was also crescent formation. Immunofluorescence revealed large IgA, IgG and C3 deposits, as well as small IgM and fibrinogen deposits in the mesangial glomeruli. The authors' assumption that immunocomplexes containing a secretory component might be implicated in the pathomechanism of Berger's disease, could not be proved.

Adolescent↗