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Biomedical subjects

J Nagy

Publications and source records attributed to J Nagy.

At least 145 records · Page 8Linked to original sources
PubMed1989

Immune complex nephropathies in patients with malignant tumours.

The authors have studied the incidence of changes related to immune complex glomerulonephritis in postmortem kidney specimens from 23 patients with malignant tumours (18 solid tumours and 5 leukaemias), using light microscopy and immunofluorescence. As revealed by light microscopy, 4 kidneys had diffuse, 2 focal mesangial proliferative glomerulonephritis and 1 IgA glomerulonephritis. Granular deposition of immunoglobulin in the mesangium was observed in 5 kidneys, on 3 occasions together with C3. In only 2 patients were, in addition to glomerular damage, clinical symptoms observed. No CEA and alpha FP were found in the diseased kidneys. The results suggest that glomerular damage with no or only occasional clinical symptoms is not rare in patients with malignant tumours.

Complement C3↗
PubMed1988

Antibodies to viruses of the herpes group in glomerulonephritis of membranous, membranoproliferative and IgA types.

Sera of 25 patients with membranous glomerulonephritis (MGN), 16 with membranoproliferative glomerulonephritis (MPGN) and 54 with IgA glomerulonephritis (IgA GN) were studied for complement-binding antibodies to herpes simplex virus (HSV), cytomegalovirus (CMV) and antibodies to various Epstein-Barr virus (EBV) associated antigens, as also for the titres of these antibodies. The sera of 220 normal individuals served as controls, 120 controls being used for each case. Anti-HSV titres of greater than or equal to 1:64 were found to occur in the sera of all three GN groups in a higher proportion than in those of the controls. This was also valid for the complement-binding antibodies to CM, although here the differences were not invariably significant. IgA antibodies reacting with EBV capside antigen (EBVCA) were likewise of statistically increased frequency in IgA GN, as also in MPGN, and in these two groups the geometric mean of the reciprocal value of the IgA antibody titres was also higher than either in the controls or in MGN. The results of the studies carried out within 6 months after onset of renal disease point to an EBV infection, either fresh or having taken place in the recent past, in 20 cases. These data are compatible with a direct or indirect role of EBV in the production and/or persistence of certain types of GN. The high anti-HSV and CMV titres suggest that in a number of patients with renal disease the immune responses to certain types of the HSV group may be abnormal.

Antibodies, Viral↗
PubMed1988

Independent GABAergic and cholinergic modulation of apomorphine-induced stereotyped rearing in the rat.

The injection of GABA into the caudate nucleus inhibited the stereotyped rearing induced by apomorphine in a dose-related manner. Muscimol, a potent GABAergic agonist shared this effect. The inhibitory effect of GABA was easily counteracted by bicuculline but not by pretreatment with atropine. Injection of carbachol into the caudate nucleus inhibited the stereotyped rearing induced by systemically-applied apomorphine in a dose-related manner. This inhibitory effect was easily abolished by atropine but not bicuculline. Thus, the stereotyped rearing induced by apomorphine, an effect due to an increased excitatory state of the dopaminergic system in the caudate nucleus, could be modified (inhibited) by augmentation of either the GABAergic or of the cholinergic state excitation. The two modulatory systems did not appear to be interlinked; most probably, they influence the dopaminergic effect independently of one another.

Animals↗
PubMed1988

Tonsillar distribution of IgA and IgG immunocytes and production of IgA subclasses and J chain in tonsillitis vary with the presence or absence of IgA nephropathy.

At the onset or in the course of IgA nephropathy (IgA NP), upper respiratory tract infections and tonsillitis are often followed by periods of gross haematuria. In a search for possible abnormalities in the tonsillar IgA- and IgG-cell system, the palatine tonsils from seven patients with IgA NP and eight controls, all 15 suffering from chronic recurrent tonsillitis, were subjected to an immunohistochemical study. Compared with the controls, tonsils of NP patients contained a significantly (P less than 0.001) increased proportion of IgA-producing cells (49.6% versus 35.7%). There was also an increase (P less than 0.001) in the ratio of IgA polymer- (J-chain-positive) to monomer-producing cells in NP tonsils compared with controls (35.0% versus 18.8%). Although the tonsillar IgA cells were generally producing mainly IgA1, this subclass was even more predominant in NP tonsils (P less than 0.03). These results are compatible with the hypothesis that in some patients with IgA NP, the polymeric IgA1 deposited in the mesangium may be of tonsillar origin.

B-Lymphocytes↗
PubMed1988

Antibodies to dietary antigens in IgA nephropathy.

It has been postulated that IgA NP is caused by mesangial deposition of IgA-containing immune complexes formed by IgA polymers (pIgA) which are overproduced in response to antigens presented at mucosal surfaces. The intestinal mucosa is one possible source of this pIgA. To test whether antibodies to dietary antigens might be involved in the pathogenesis of IgA NP, we measured IgG and IgA serum antibody activities to gluten, a gluten fraction called glyc-gli, alpha-lactalbumin, beta-lactoglobulin, casein and ovalbumin in 54 patients with IgA NP by an enzyme-linked immunosorbent assay (ELISA). The IgA activities to gluten antigens and alpha-lactalbumin were significantly increased in IgA NP compared with a group of 40 age-matched healthy controls. In a previous study we found that 4 out of 12 patients with IgA NP and gastrointestinal complaints had subtotal villous atrophy; this indicated that many patients with IgA NP have altered intestinal permeability which may lead to activation of their intestinal immune system. Taken together our results showed a relation between the intestinal humoral immune system and IgA NP and indicated that antibodies to dietary antigens in some patients may be directly involved in the pathogenesis of IgA NP.

Adult↗
PubMed1987

Cryoglobulinaemia and cryofibrinogenaemia in IgA nephropathy: a follow-up study.

Sera and plasmas from 50 patients with IgA nephropathy (IgA-NP) have been investigated for the presence of cryoglobulin (CG) and cryofibrinogen (CF), respectively, 2-5 cryoprotein determinations being made for each patient. CG was transiently found in 20 of 50 patients (40%), but in none of 20 healthy blood donors, whereas CF was found in 37 of 50 patients (74%) and in 4 of 20 healthy blood donors. The cryoprecipitates were of single and mixed component types. All but 2 of the patients with CF had haematuria. Nearly all of them had histories of long exposure to the cold as manual workers at the onset or recognition of their disease. There was no clinical remission during a 2-to-5-year follow-up if cryoproteinaemia persisted. A certain correlation was detected between the composition of the CP and the renal immunohistological findings. It is suggested that renal deposition of circulating CF or local formation of CF might be responsible for the tubulo-interstitial fibrocellular changes, which are of prognostic importance.

Adolescent↗
PubMed1987

Subpopulations of T-lymphocytes in IgA glomerulonephritis.

Peripheral subpopulations of T-lymphocytes were studied morphologically, cytochemically and with monoclonal antibodies (Leu 1, Leu 2a, Leu 3a) in 27 IgA glomerulonephritis cases and in 15 healthy controls. The number of helper T-lymphocytes was found significantly increased particularly in the active phase of IgA glomerulonephritis, while that of suppressor lymphocytes decreased. Thus helper/suppressor ratio increased significantly. In the inactive phase this ratio was also seen to increase but not in a significant manner. Comparing different methods used it is concluded that all of them proved to be suitable for the demonstration of altered subpopulation ratios.

Adolescent↗
PubMed1987

Tubular proteinuria in IgA glomerulonephritis.

In the renal biopsy samples of some patients with IgA glomerulonephritis (IgA GN), tubulointerstitial changes and a significant correlation between these changes and the serum creatinine levels had been observed earlier. In order to get an insight into the function of the tubules, 45 patients with IgA GN have been examined for proteinuria with special reference to low molecular weight (LMW) proteins, also called tubular proteins using sodium-dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE). Thirty-seven of the 45 patients had proteinuria (200-1890 mg/day). On the basis of the middle molecular weight/high molecular weight (MMW/HMW) protein ratio, the proteinuria was non-selective in 28. Twenty-nine patients had 40-200 mg LMW protein/day in the urine. There was a statistically significant correlation between the tubulointerstitial changes seen in the renal biopsy samples (characterized by the tubulointerstitial index) and the tubular proteinuria. On the basis of these results it is suggested that in most patients with IgA GN there is, in addition to the glomerular lesion, also morphological and functional tubulointerstitial damage, which is in connection with the progression of the disease.

Adult↗