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Biomedical subjects

J Marek

Publications and source records attributed to J Marek.

At least 199 records · Page 11Linked to original sources
PubMed1984

Urinary excretion of free catecholamines in long-term treatment with dopaminergic agonists.

Urinary excretion of free adrenaline, noradrenaline and dopamine was examined in 12 patients with active acromegaly before and during long-term therapy (6-22 months) with ergoline derivatives bromocriptine (20-30 mg daily) and lisuride (1-2 mg daily). A significant fall in noradrenaline values (4.5 +/- 0.95 (SEM) nmol/h on v.s. 15.3 +/- 3.8 nmol/h before the treatment, P less than 0.01) was found in the treated patients. Adrenaline excretion rose in most patients but the difference was not significant (1.43 +/- 0.33 nmol/h on v.s. 1.02 +/- 0.36 nmol/h before the treatment, P greater than 0.05). No significant change was seen in the dopamine excretion (71.3 +/- 9.58 nmol/h on v.s. 75.0 +/- 7.0 nmol/h before the treatment, P greater than 0.05). Our studies confirm the blood pressure lowering effect of bromocriptine and lisuride even when used on a long-term basis. This effect seems to be associated with reduced sympathetic activity.

Acromegaly↗
PubMed1984

[Carcinoma of the hypophysis with acromegaly].

A 38-year old man deceased after being operated on recurring pituitary adenoma removed 13 years ago. Autopsy showed a massive spread of tumour on dura and in subarachnoid space. Growth hormone producing cells were found prevailing in the primary tumour as well as in secondaries by immunohistochemistry and immunofluorescence which concurred with acromegaly. Many cells produced prolactin. The tumour spreading discontinually in subdural and subarachnoid space was taken for a carcinoma.

Acromegaly↗
PubMed1983

[Drug therapy of hyperprolactinemia, acromegaly and Cushing syndrome].

39 patients with hyperprolactinaemia (32 adenomas of the pituitary gland, 7 idiopathic hyperprolactinaemias) were treated with the ergot derivative Lisurid. In 3 patients side-effects appeared which did not allow an increase to the therapy-effective dose. In all other patients with a dose of 0.075 to 6 mg Lisurid a day a normalisation of the prolactinaemia was achieved. A pregnancy appeared in 15 of 16 women who wished a child. In 4 men with normal gonadotropic reserve libido, potency and plasma testosterone normalised after the treatment with Lisurid. In addition of Lisurid also other ergot derivatives with prolactin-inhibiting effect, such as dironyl, deprenone and propyldeprenone were tested. Here dironyl has an advantage showing less side-effects and no changes of blood pressure. The ergot derivatives may be used also in the treatment of acromegaly. In 7 of 21 patients with acromegaly who were treated a longer time we succeeded in reducing the level of the growth hormone below 50%, in 2 patients the condition completely normalised. On the other hand, a normalisation of the somatomedin level appeared only in 11 of 21 patients. Patients with central Cushing's disease only exceptionally react to the treatment with ergot derivatives.

Acromegaly↗