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Biomedical subjects

J Lissner

Publications and source records attributed to J Lissner.

At least 109 records · Page 6Linked to original sources

Indication for, and valuation of computed tomography following anterior resection of the rectum.

During a controlled study, 55 patients who had an anterior resection of the rectum were thoroughly examined, including by computed tomography. The results verified the following statements: 1. The use of CT as a screening-method for early detection of local tumour recurrence following anterior resection of the rectum appears not to be justified. 2. CT is indicated: a) if there is a laboratory or clinical suspicion of recurrence, despite normal findings on proctoscopy; b) to clarify the question of extramural extension if recurrence has been established by proctoscopy. 3. Following anterior resection of the rectum, CT normally demonstrates no remarkable development of scar tissue, unless the anastomosis is inadequate. 4. Following anterior rectal resection every indefinable tissue thickening in the pelvis must be considered a possible tumour recurrence and must be further investigated by needle biopsy.

Carcinoma↗

[Xeroradiography and conventional radiological methods in chronic polyarthritis (author's transl)].

Xeroradiograms and conventional radiographs of the hands of 50 patients with chronic polyarthritis were performed. These were compared with regard to the features which are found in chronic polyarthritis. There were no significant differences between xeroradiography and conventional radiology. Xeroradiography was a little better for demonstrating changes in the soft tissues and erosions, but conventional radiographs were superior in showing osteoporosis, cysts and the absorption of subchondral lamellae. In general, xeroradiography and conventional procedures were of equal value in the diagnosis of chronic polyarthritis. For practical purposes, conventional radiography is to be preferred and xeroradiography may be regarded as an additional procedure, particularly for the investigation of soft tissue changes.

Adult↗

[Computed tomography and densitometric pattern of pulmonary lesions (author's transl)].

Fifty-five peripheral pulmonary lesions in 46 patients were examined by computed tomography. The results were correlated with histologic diagnoses. The series comprised 26 bronchial carcinomas, 17 metastases, 4 chondromas, 5 tuberculomas and 3 echinacoccal cysts. The high resolution capacity of CT in the evaluation of macro pathologic pattern specially with the electronic image processing, with densitometry in regional interest is emphasised. Therefore cysts, fatty and other solid masses in the lung can be distinguished. Further more one can gain information of the underlying tissue on the basis of absorption profile.

Absorptiometry, Photon↗

Computed tomography in constrictive pericardial disease.

Thirteen patients with pericardial abnormalities and a question of constrictive hemodynamics underwent contrast enhanced cardiac computed tomography (CT). Those with clinical and catheterization evidence of restricted cardiac filling demonstrated three CT signs: a dilated IVC, a deformed ventricular contour, and an angulated interventricular septum. Patients with pericardial fluid, thickening, or calcification but without evidence of constriction showed none of these signs. Cardiac CT also defined sites of particular constriction for subsequent resection.

Adult↗

The visualized interventricular septum on cardiac computed tomography: a clue to the presence of severe anemia.

Severe anemia (10 g hemoglobin or less) will provide sufficient negative contrast on computed tomography (CT) to visualize the intracardiac chambers or lumina of large blood vessels. In the presence of secondary hemochromatosis, imaging of the interventricular septum can be due to excess cardiac iron (hemochromatotic cardiomyopathy) or the underlying transfusion-dependent anemia. Five percent glucose/water may be a satisfactory negative contrast agent for cardiac CT.

Anemia↗

[The diagnostic value of computerized tomography in mediastinal diseases depending on their localization].

The diagnostic ranking and importance of computerised tomography was examined in 116 patients with abnormal findings in the mediastinal region, and was compared with conventional, non-invasive x-ray examinations. This method also yielded significant CT-specific additional information in the anterior mediastinum in 74.4% of the cases, in the mesomediastinum in 69.1%, in the posterior mediastinum in 79.2% in the upper thoracic aperture in 94.4% and in the paracardial region in 100% of the cases. The hilar region is an exception; in 68.8% of the cases, both methods were rated equal, whereas in 28.1% of the cases assessment via the CT method was even inferior. The specific additional information furnished by the CT method justifies a wider application of CT in solving the following problems concerning the mediastinum. -- clarification of a suspected but not yet established space-occupying growth in the mediastinum, before using invasive diagnostic methods such as mediastinoscopy and angiography; -- staging of an already identified primary mediastinal tumor of malignant lymphoma; -- in case of suspected changes in the large mediastinal vessels before employing angiography; -- on-target in the following diseases: bronchogenic carcinoma (because of improved pretherapeutic staging according to the TNM system), myasthenia gravis and identification of thymoma, hyperparathyroidism with suspected dystopic parathyroid glands.

Aortic Dissection↗

[End-diastolic volumes of the left ventricle in computer tomography in comparison to heart catheter ventriculography].

In 47 patients the authors calculated the volume at the end of a diastole according to both the cardiac catheter ventriculogram and the CT ventriculogram, comparing the results obtained with each of these methods. A linear regression was found. The correlation coefficient was approximately r = 0,96; n = 47. Cardiological examination revealed that of the examined patients (including the cardiac catheter finding) 18 patients had coronary heart disease, whereas 9 had cardiomyopathy, 6 arterial hypertension, 9 had various cardiac abnormalities and 5 did not show any organically manifest heart disease. The article discusses CT determination of the volume at the end of the ventricular diastole, and discusses the results.

Cardiac Catheterization↗

[Radiation therapy of tumors of the hypopharynx (author's transl)].

A follow-up study of 69 patients with malignant tumors of the hypopharynx is reported. They were treated either with Cobalt-60-gamma-rays or with 19 MeV Betatron X-rays mainly up to a dose of 60 Gy over a 6 week period. 53 of the 67 patients with carcinomas had very large tumors (T3 and/or N3). The 3-year survival rate in group N0 was 15%, and in group N1--3 7%. These rates could not be improved on by radical operations prior to radiotherapy. 51 of the 67 patients with carcinomas died due to local or regional disease. 7 patients developed distant metastases. These results could not be improved on by increasing the dose to 70,0 Gy.

Carcinoma↗

[Sonographic determination of thyroid volume. Comparison with other methods (author's transl)].

Using ultrasound it is possible to determine the thyroid volume with a maximal error of 12%. The method is based on the electronic planimetry of a sequence of transverse ultrasound scans of the thyroid. Following this, the "slices" are added using a small computer. On 101 patients five commonly used methods of volume determination were compared with this reference technique. The volume estimation by palpation and interpretation of the scintigram as well as the volume calculation from the scintigram area or from an ellipsoid model gave maximal errors between plus or minus 82% and plus or minus 90%. The combination of scintigram area or scintigraphically determined length and width of a single thyroid lobe and the sonographically measured thickness reduced the maximal error to plus or minus 35% and plus or minus 37%. In 10 patients teh reproducibility of the reference technique was excellent and the absolute maximal error was 4.6%, even when the patients were differently positioned.

Adolescent↗

[Computerized tomography of the liver. Accuracy of the method in biopsy proven diagnoses (author's transl)].

To evaluate the diagnostic accuracy of computerized tomography (CT) in detecting liver disease, CT-findings of 320 patients examined with a slow CT-scanner (2.5 min scanning time/slice) could be compared to the results of bioptic procedures. Sensitivity was 81% for circumscript liver disease, specificity was 85%. In 69% of the cases, a type-specific diagnosis of circumscript liver diseases was possible, this percentage increased by 5% if patients with a true-positive differential diagnosis were included. 73% of the patients with liver metastases were correctly identified to have metastatic liver disease. Obstructive jaundice was correctly identified in 77% and correctly excluded in all patients with medical jaundice. For a large variety of hepatocellular disease, ratio of true positive diagnoses was 16% only. The value of CT in hepatocellular disease concerns exclusion of presumed space-occupying lesions. In a control group of 310 patients with only "clinically" and not bioptically confirmed diagnoses, specificity was 96% and sensitivity concerning focal liver disease was 82%. Our results prove CT to be a valuable non-invasive tool in the evaluation of circumscript liver disease.

Biopsy↗

[Determination of the iodine content of the thyroid by means of fluorescence scans (author's transl)].

A procedure is described in which stable 127I in the thyroid is induced to fluorescence (28.5 keV) by 241Am (59.5 keV). The radiation is registered on a Si (Li) detector and can be used in order to obtain a scintigram or to determine the concentration of127I in the thyroid at any selected point. The apparatus is available commercially and has been adapted for use with a scanner. Measurements using collimation of 3.5 to 4 cm revealed a focus with a marked tomographic effect. The sensitivity of the apparatus was investigated by using solutions of varying iodine concentrations; calibration curves for determining iodine concentration in thyroid tissue were obtained. It is necessary to take account of the thickness of the thyroid gland and of the superficial tissues because of the marked attenuation of the radiation within the tissues. Radiation dose to the thyroid during the scintigram was about 0.1 mGy (10 mrd), i.e. about 5% of a conventional TC scintigram. There is no whole body irradiation.

Humans↗