Biomedical subjects
Publications and source records attributed to J Lang.
Explore the source record for details and available documents.
Arriving current, width and course of the arteries of the outer nose were investigated at 40 headhalves. We defined 4 groups of vessel patterns. Also 6 types of variations were described and right-left-differences were determined. The results are discussed in detail with the dates of former scientists.
Explore the source record for details and available documents.
The length of the oculomotory nerve in the midbrain, in the cisterns, and the orbit to the muscles Mm. rectus superior, rectur inferior, obliquus inferior, and rectus medialis are measured on 91 objects. Also the distances between the margins of the orbit and the most anterior nerve fibers to the muscles are estimated.
The intraorbital, intracanalicular, and intracranial length of the optic nerve was measured. Also the length of the optic tract between chiasm and lateral geniculate body was estimated. Included are the ampulla of the optic sheaths, the course of the ophthalmic artery, and the distance of the ciliary ganglion to the lateral margin of the orbit.
The displacement of the fourth Purkinje image, obtained photographically, is used to assess the presence of small angles of deviation (microtropia).
Nuclear DNA is looped by attachment to a matrix or cage. As this cage is the site of DNA synthesis, sequences in the loops must attach before they are replicated. We have tested whether sequences which initiate replication are usually out in the loop and attach only during S phase or whether they are attached but quiescent during most of the cell-cycle. Sequences which permit plasmids to replicate autonomously in yeast cells (ARS's) are strong candidates for initiating sequences. Four different human ARS's all map remote from attachment points to the HeLa nuclear cage. In addition a potential terminus of replication is also remote from the cage. We conclude that sequences involved in initiation are usually out in the loop and that DNA synthesis is initiated by their attachment.
In the heart in situ of vagotomized dogs, atrioventricular conduction was studied by the His bundle potential recording, sinus rate continuously registered and the effective refractory period (ERP) of the atrial muscle measured by the extrastimulus method. The modifications induced by the acute lowering of plasma potassium concentration from 3.5 to 2.0 mmol/l obtained by hemodialysis appeared to be similar to those due to parasympathetic stimulation and the effects of hypokalemia and acetylcholine (ACh) on the atrioventricular (A-V) and sinoatrial nodes as well as on the atrial contractile tissue gave rise to potentiation. Intraaortically injected near coronary ostia in a dose lower than liminal dose, ACh enhanced to a large extent all the phenomena elicited by hypokalemia, since the variations respectively observed under the influence of hypokalemia alone and the combination of hypokalemia and ACh were as follows: lengthening of conduction time in the A-V node by 100 and 180%, reduction of sinus rate by 10 and 20%, shortening of the atrial ERP by 20 and 40%.
Explore the source record for details and available documents.
Subtraction angiocardiography (DSAK) with a fully digitalised system (DR 960) provides a well defined demonstration of the left ventricle after peripheral venous contrast injection. Cardiac volume and ejection fractions were calculated by a dedicated software programme and the findings correlated with cine ventriculography (CA) (r = 0.91), biplane echo cardiography (2 DE) (r = 0.77) and radionucleid ventriculography (RNV) (r = 0.85); the method can be used even with reduced cardiac output (EF less than or equal to 15%). Densitometric measurements of the EF on phantoms correspond with morphometric findings, but its clinical application is at present not possible because of the frequent appearance of artefacts. Analysis of regional disturbances of ventricular wall movements shows very good correlation between DSAK and CA and these appear more accurate than 2 DE. DSAK is a valuable, rapid and reproducible method with few side effects for cardiological diagnosis.
The course and lengths or the cranial nerves in the lateral wall of the cavernous sinus (Parkinson's triangle) and their relations to the internal carotid artery are described.
The distance between the area pterionalis and the optic nerve, the depth of the recess of for the temporal pole and the form of the lateral part of the sphenoidal wing are described.
The olfactory bulb has a length of 12.27 mm whereas the length of the olfactory tract from the beginning to where it crosses the optic nerve is 21.2 mm (mean). The intracranial portion of the optic nerve is 10.3 mm long. From the brain stem to its dural exit the III nerve measures 18.82 mm, and the IV nerve 32.65 mm. The range of variation in the lengths of the nerves, as well as their immediate relations are included in the investigation.
The mean length of the fifth nerve in the posterior fossa is 13.38 mm (medial portion) and 12.01 mm (lateral portion). Measurements of the triangular part of the trigeminal nerve, its branches and its central (vulnerable) part, are also described.
Explore the source record for details and available documents.
A double-blind prospective controlled study designed to determine the effectiveness of the addition of cimetidine to standard treatment of acute alcoholic pancreatitis and to determine the importance of nasogastric suction in this disorder was undertaken. Forty-five patients were randomized to one of four treatment groups: 1) group I received intravenous cimetidine plus a blinded nasogastric tube, 2) group II received intravenous cimetidine plus nasogastric suction, 3) group III received nasogastric suction plus cimetidine placebo, and 4) group IV received a blinded nasogastric tube plus cimetidine placebo. Patients were evaluated via both biochemical and clinical parameters. It was concluded that 1) cimetidine added to more traditional therapy does not hasten improvement in patients with acute alcoholic pancreatitis, 2) cimetidine may delay recovery as measured by both clinical and biochemical measurements, 3) nasogastric suction appears indicated, under most circumstances, only in those patients with ileus and/or nausea and emesis.
Explore the source record for details and available documents.
Origin, width, course and twigs of the ascending pharyngeal artery are investigated on 63 head-helves. In about 80% this vessel is a twig from the external carotid artery or from a common trunc from this vessel. In 20% there is a twig from an other artery (In 4,8% the ascending pharyngeal artery is a twig of the internal carotid artery). The ascending pharyngeal artery is 1.57 (0.9-2.3) mm in width and its course is in the most cases straight, medial, mediorostral or laterorostral from the internal carotid artery in the parapharyngeal spaces. Number, course and width of the pharyngeal rami, the rami to the lymphatic nodes, to the superior sympathetic ganglion, the prevertebral tissues in the neighbourhood of the carotic canal, to the external cranial base, to the nasal part of the pharynx and to the hypoglossal canal are prepared and studied. The clinical value is discussed.