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Biomedical subjects

J Kjaergaard

Publications and source records attributed to J Kjaergaard.

At least 91 records · Page 5Linked to original sources
PubMed1984

Dihydroergotamine in prevention of infusion thrombophlebitis. A randomized trial.

The efficiency of subcutaneous dihydroergotamine in preventing infusion thrombophlebitis was assessed in a randomized trial. One hundred and fourteen postoperative patients were studied. They furnished a total of 160 infusion sites. The difference between treatment and control group with regard to incidence of infusion thrombophlebitis was not significant (p greater than 0.05). Accordingly dihydroergotamine has no substantial effect.

Clinical Trials as Topic↗
PubMed1984

Hartmann's operation as an emergency procedure for perforation of the sigmoid colon. A consecutive series.

A consecutive series of 19 patients with acute perforation of the sigmoid colon, were subjected to Hartmann's procedure. The rationale for primary resection of the diseased segment of the bowel is to remove the source of sepsis. The operation took approximately 2 1/4 hours, the temperature was normalized within 2 days and the hospital stay was 22 days. The perforations were caused by cancer in 4 patients. Half of the patients developed postoperative complications, mainly wound sepsis. There was one postoperative death, caused by pulmonary embolism. Approximately three months later a colorectal anastomosis was performed on 11 patients. Our experience confirms that Hartmann's procedure is the treatment of choice for patients with acute perforation of the sigmoid colon.

Adult↗
PubMed1984

Ulcer recurrence after parietal cell vagotomy for duodenal ulcer. A multivariate pattern recognition study.

The object of the study was to identify individual high-risk patients with regard to ulcer recurrence after parietal cell vagotomy for duodenal ulcer. The study comprises a multivariate analysis of 14 variables (age, sex, duration of symptoms, site of ulcer, pre- and post-operative acid secretion) for 37 patients with and 111 patients without recurrence 5-11 years after parietal cell vagotomy for duodenal ulcer. The data were analyzed using a supervised pattern recognition technique, SIMCA (Soft Independent Modeling of Class Analogy), which analyzes complex data as geometrical elements in a multidimensional space. We found no statistical difference between the patients with and without ulcer recurrence. Thus, no predictive value for the selection of patients liable to develop recurrent ulcer after parietal cell vagotomy was contained in the variables generally registered in current surgery.

Adult↗
PubMed1983

Heparin with and without dihydroergotamine in prevention of thromboembolic complications of major abdominal surgery. A randomized trial.

We compared the results of dihydroergotamine mesylate administered with low-dose heparin sodium with those of low-dose heparin given alone in a randomized trial based on 181 patients who underwent major abdominal surgery. We found no significant difference in the incidence of thromboembolism between the two groups but a higher incidence of abnormal fibrinogen uptake test results in patients given heparin alone. There was no difference in hemoglobin levels and the number of blood transfusions. We concluded that there is little, if any, clinical advantage in adding dihydroergotamine to low-dose heparin to prevent thromboembolic complications in patients who have undergone major abdominal surgery.

Abdomen↗
PubMed1983

Dihydroergotamine in postoperative ileus.

The effects of dihydroergotamine (DHE) on postoperative ileus after major abdominal surgery were studied. Forty-one patients received 0.5 mg DHE subcutaneously twice a day from the day of surgery to the seventh postoperative day. Thirty-three patients served as controls. There were no significant differences in the time to the first postoperative passage of flatus or delivery of stools nor in the quantity of laxatives given. It is concluded that DHE does not reduce the duration of postoperative ileus.

Adult↗
PubMed1983

Ulcer recurrence two to twelve years after parietal cell vagotomy for duodenal ulcer.

An analysis is presented of the ulcer recurrence rate following parietal cell vagotomy in 333 patients with duodenal ulcer. The median period of observation for patients without ulcer recurrence was 54 months (range 1 to 128 months). Forty-two patients developed proven recurrent ulcer. The median period of freedom from recurrence was 33 months (range 3 to 113 months). Recurrent ulcer was suspected but not verified in an additional 12 patients. The calculated risk (by the life table method) of recurrence after 5 years was 13% (95% confidence limits 9-17), after 8 years 21% (14-28), and after 10 years 23% (15-31). The rate of recurrence remained constant throughout the study period. The analysis indicates a constant monthly recurrence risk of 0.23%. The patients with ulcer recurrence had a significantly lower reduction of peak pentapeptide acid output and higher rate of positive insulin test than patients without recurrence. The risk of recurrence did not depend on the location of the ulcer (duodenal bulb or pyloric-prepyloric area).

Adult↗
PubMed1982

Sclerotherapy of bleeding esophageal varices. Long-term results.

Sixty-one patients presenting with hemorrhage from esophageal varices were treated with sclerotherapy by means of a fiberoptic endoscope. Twenty-nine had acute bleeding, which was stopped in 90%. Thirty-two were treated after recent bleeding. The hospital mortality was 31%. Re-bleeding occurred in 55% of those discharged but was easily controlled. Fatal complications occurred in 5%. The calculated 4-year survival was 35%. Two thirds of this mortality could be attributed to liver failure. The intellectual function of the patients appeared to be unaffected.

Adult↗
PubMed1981

The ultrastructure of the dermo-epidermal junction in lichen planus.

The ultrastructure of the dermo-epidermal junctional area in biopsy material from 5 patients suffering from lichen planus has been studied during treatment with steroids. Tannic acid was used on the tissue blocks in order to provide high and diversified contrast for electron microscopy. The changes observed in the basal cells consisted mainly of degeneration of the mitochondria and disorganization of the tonofilaments. No ultrastructural changes were seen in the basal lamina, apart from occasional gaps, whose significance for pigment incontinence in old lichen planus lesions is discussed. Cellular infiltration was seen in the dermis, while the ultrastructure of the collagen fibrils of the papillary layer was normal. It is suggested that degeneration of mitochondria with subsequent disturbance of the organization and fixation of tonofilaments are events in the pathogenesis of the condition.

Adolescent↗
PubMed1981

Pancreatic pseudocysts. A follow-up study.

From 1968 to 1978, 37 men and 14 women, with a median age of 43 years, were operated on for a pancreatic pseudocyst. Alcohol abuse was the dominating cause in 65% of the patients. Internal drainage (medium risk patients) was carried out in 76%, external drainage (high risk patients) in 12%, and pancreatic resection (low risk patients) in 12% of the patients. The hospital mortality rate was 14%. The patients who died were significantly older than those discharged from the hospital alive. At the time of follow-up (1--11 years, median: 4 years) after operation, a further 13% had died. Thirty per cent of the alcoholic and none of the nonalcoholic patients had severe pain at follow-up examination. Evaluated by their ability to work and pain, the late results were poorer for the alcoholics who continued drinking, better for alcoholics who had stopped drinking and best for nonalcoholics.

Adolescent↗
PubMed1981

Cimetidine treatment of patients with duodenal ulcer referred to a surgical clinic.

Fifty-seven patients with gastroscopically verified duodenal ulcer after being referred to a surgical department were treated with one gram of cimetidine daily for 4 weeks. Within the period of observation 6-16 months (median 9) there was indication for operation in 36 patients, 16 were free from symptoms and five had slight symptoms. Those with freedom from symptoms over a longer period all had gastroscopically verified ulcer healing at control gastroscopy following discontinuation of the treatment. Ulcers localized to the pyloric/pre-pyloric areas had a poorer symptomatic effect of treatment than those situated to the bulb.

Adult↗
PubMed1980

Inadequately reduced acid secretion after vagotomy for duodenal ulcer. A follow-up study three to nine years after surgery.

In a study of 545 patients who underwent vagotomies for repair of duodenal ulcers, 62 patients (11%) were found to have inadequately reduced pentapeptide and/or insulin-stimulated acid secretions three months after operation. The ulcers recurred in 14 patients within three to nine years (mean: four years) (23%, 95% confidence limits: 13-35). Postoperative acid production and acid reduction were equal in patients with and without ulcer recurrence. The patients who did not develop recurrent ulcers had significantly lower preoperative pentapeptide peak acid outputs and significantly shorter preoperative histories of ulcers than patients whose ulcers recurred.

Duodenal Ulcer↗