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Biomedical subjects

J Kjaergaard

Publications and source records attributed to J Kjaergaard.

At least 73 records · Page 4Linked to original sources
PubMed1988

Postoperative fever after major abdominal surgery.

The investigation is a report of postoperative fever in 608 patients, who had been subjected to major abdominal surgery. There were 259 patients (259/608: 43%) who developed fever, defined as a temperature higher than or equal to 38 degrees C, on at least two consecutive measurements. A focus as an explanation of the fever could be demonstrated in 93 patients (93/259: 36%). The most frequent extraabdominal fever foci were in order of magnitude: pulmonary infection, wound infection and urinary infection. In those patients where a focus was present the maximum temperature as well as the duration of fever was longer than in patients without a focus. The time from operation to onset of fever did not differ in the two groups.

Abdomen↗
PubMed1987

Enprostil and ranitidine in prevention of duodenal ulcer relapse: one year double blind comparative trial.

One hundred and forty two patients with duodenal ulcer who after a short term study had relief of pain and healed ulcers proved endoscopically were allocated at random to double blind maintenance treatment with enprostil (a synthetic dehydroprostaglandin E2) 35 micrograms or ranitidine 150 mg at bedtime for up to 12 months. Patients were monitored every third month and examined by endoscopy at three, six, and 12 months, or more often if warranted. The cumulative relapse rates in the enprostil group at three, six, and 12 months were 37% (25/67), 56% (37/66), and 62% (41/66), respectively. The corresponding rates in the ranitidine group were 8% (6/71), 19% (13/69), and 29% (20/69). These differences were highly significant and further enhanced by life table analysis adjusting for withdrawals and by an "intention to treat" analysis in which absence of proof of non-recurrence was counted as failure, more patients in the enprostil group having been withdrawn because of adverse events or recorded as non-compliant with the protocol. Enprostil 35 micrograms at bedtime cannot be recommended for preventing relapse of duodenal ulcer. Furthermore, the results challenge the clinical relevance of using so called "cytoprotection" for preventing recurrence.

Adult↗
PubMed1987

The predictive value of preoperative perfusion/ventilation scintigraphy, spirometry and x-ray of the lungs on postoperative pulmonary complications. A prospective study.

Prospectively, 125 patients were examined with 99mTc-perfusion scintigraphy, 89mKr- or 127Xe-ventilation scintigraphy and chest radiogram prior to major surgery. Postoperative therapy-demanding pulmonary complications occurred in 18% of the patients. A statistical association could be demonstrated between all the preoperative tests except ventilation scintigraphy and the frequency of complications. However, the predictive values of each of the tests, or even the combined results, were not significantly different from the frequency of complications among all the patients. It is concluded that the predictive values of perfusion- and ventilation scintigraphy, spirometry and radiogram of the chest are too low to be of any practical use.

Adult↗
PubMed1987

Non-sutured fibrin adhesive vs. sutured anastomosis. A comparative intra-individual study in dog colon.

In each of ten dogs the colon was subjected to a two-layered sutured anastomosis and a non-sutured fibrin adhesive anastomosis. Intra-individual comparisons showed no significant difference of in vivo bursting strength after 7 days between the colon segments with sutured and those with non-sutured anastomoses. Under experimental conditions it was thus possible to achieve a safe, sutureless anastomosis in the colon using only fibrin adhesive.

Anastomosis, Surgical↗
PubMed1986

Tissue adhesives and intestinal anastomosis.

This article presents a review of the literature concerning the employment of tissue adhesives in the production of intestinal anastomoses. The fibrin adhesive is the tissue adhesive of choice in as much as it is physiological does not possess histotoxicity or cause allergic reactions. Fibrin adhesive sealing of a conventional sutured anastomosis might improve this anastomosis as it reduced the postoperative mortality-rate significantly in a prospective study with a retrospectively matched control group comparing sealing and no sealing, but prospective, randomized trials are lacking. Finally a cyanoacrylate intestinal anastomosis has proved obsolete as in experimental trials it has proved inferior to the conventional anastomosis.

Animals↗
PubMed1985

A multivariate pattern recognition study of risk-factors indicating postoperative thromboembolism despite low-dose heparin in major abdominal surgery.

The object of the present investigation was to identify those who, among high-risk patients, would "break through" low-dose heparin prophylaxis and develop thromboembolism after major abdominal surgery. Twenty-nine variables (clinical characteristics, pre- and postoperative coagulation and fibrinolytic factors) from 19 patients with and 26 patients without thromboembolism were analyzed by means of a multivariate supervised pattern recognition technique (SIMCA). We found no statistically significant difference between patients with and without thromboembolism. Thus, in the studied group of high-risk patients it was not possible to identify a predictive index for selection of individual patients liable to develop postoperative thromboembolism despite low-dose heparin prophylaxis in major abdominal surgery.

Abdomen↗
PubMed1985

Probability of false negative nodal staging in conjunction with partial axillary dissection in breast cancer.

There is a risk of overlooking lymph node metastases and thereby contributing to inaccurate nodal staging when performing partial axillary dissection in conjunction with total mastectomy in female breast cancer. The Danish Breast Cancer Cooperative Group (DBCG) analysed this risk in a prospective nation-wide adjuvant trial dealing with primary operable breast carcinoma. The series comprised 3114 patients, initially found to have lymph node negative axillae, followed for a median of 24 months (quartiles 12-40). It was found that the probability of early ipsilateral axillary relapse of cancer, estimated by means of the life table method, decreased with the number of nodes removed. After 2 years the recurrence rate was 12 per cent for patients with no lymph nodes removed, 7 per cent with one or two nodes removed and 2 per cent with three or more nodes removed. It is concluded that the risk of false negative nodal staging in conjunction with partial axillary dissection is modest, provided at least three lymph nodes are removed and found to be negative on histological examination.

Adult↗
PubMed1985

Nonchromaffin paraganglioma of the retroperitoneum.

We reviewed 37 cases described previously in the literature to provide a patient operated upon for a retroperitoneal nonchromaffin paraganglioma with qualified advice concerning followup examinations and prognosis. This type of tumor apparently grows slowly and metastasizes late. A radical operation is the treatment of choice and provides a good prognosis. We suggested that our patient undergo clinical followup and ultrasound investigations at 3 to 6-month intervals.

Adult↗
PubMed1985

Isoamylases and their thermolability in serum and cyst fluid from patients with pancreatic pseudocysts.

The isoamylase pattern in serum and the amylase thermolability have been suggested as screening tests for the development of pancreatic pseudocysts. To study whether serum reflects the contents of pseudocysts, we have investigated the isoamylases and their thermolability in cyst fluid and in serum from 13 patients with pancreatic pseudocysts. No significant correlation was found between the contents in serum and cyst fluid with regard to total amylase and isoamylase P2 and P3 or with regard to the thermolability of total amylase and isoamylase P2 and P3. Thus, serum does not reflect the cyst contents of isoamylases or their thermolability. Therefore these serum amylase determinations can hardly be expected to be useful in distinguishing patients developing pseudocysts among patients with pancreatitis.

Adult↗
PubMed1985

Evaluation of symptoms and signs of gallstone disease in patients admitted with upper abdominal pain.

We present a prospective evaluation of the diagnostic value of 37 symptoms and signs of gallstones in 192 patients admitted with upper abdominal pain. The study was carried out independently of the examination and treatment by the staff. The routine investigations showed 49 patients with gallstones. Univariate analysis showed that old age, previous similar attacks of pain, previous intolerance to fatty foods, severe (that is, requiring analgetic injections) and radiating pain, and tenderness in the upper right quadrant were significantly more frequent in patients with gallstone disease than in those without. The evaluation showed that the classical signs and symptoms are relatively poor in establishing the diagnosis of gallstone disease, but their absence is a relatively good indicator for excluding the diagnosis. The multivariate analysis showed that the diagnosis of gallstone disease than in those without. The evaluation showed that the classical signs and and symptoms are relatively poor in establishing the diagnosis of gallstone disease, but their absence is a relatively good indicator for excluding the diagnosis. The multivariate analysis showed that the diagnosis of gallstone disease depends, in the main, on intolerance to fatty foods, severe pain, and tenderness in the upper right quadrant. The other classical signs and symptoms depend on and vary mutually with these three.

Abdomen, Acute↗
PubMed1985

Ultrasound diagnosis of carcinoma of the urachus.

In a 48-year-old man with dysuria and microscopic haematuria, pyelography, cystoscopy and bimanual bladder palpation showed no definite abnormality. Because of continued symptoms, ultrasound scanning of the abdomen was done three months later. The examination revealed a tumour in close relation to the top of the bladder. Malignant cells were aspirated at ultrasonically guided puncture, and a urachus tumour was suspected. For early diagnosis of urachus tumours, ultrasound investigation of vague bladder symptoms is required.

Adenocarcinoma, Mucinous↗
PubMed1985

Postoperative thromboembolic complications despite heparin prophylaxis in major abdominal surgery.

181 patients who received low-dose heparin prophylaxis in connection with major abdominal surgery were screened for postoperative thromboembolism by means of the 125 I-fibrinogen uptake test, venography and ventilation/perfusion lung scans. Among a number of potential risk factors analyzed only colonic surgery and preoperative anaemia were associated with significantly increased risk of postoperative thromboembolism.

Abdomen↗
PubMed1984

Colostomy irrigation with prostaglandin E2 and bisacodyl. A double-blind cross-over study.

The emptying of the colon and the side-effects after intraluminal application of prostaglandin E2 and of bisacodyl in 14 patients was studied by employing colostomy irrigation. The design was double-blind with cross-over, the irrigation was one litre of tap water to which was added in randomized sequence placebo, prostaglandin *2 (350, 700 and 1400 micrograms) or bisacodyl (1.25, 2.5 and 5 mg). Neither prostaglandin E2 nor bisacodyl had any significant effect.

Adult↗
PubMed1984

Prognostic significance of residual cancer tissue after diagnostic biopsy in breast carcinoma. Three-year short-term results.

Among 3264 cases of breast carcinoma undergoing diagnostic biopsy and frozen section followed by one-stage mastectomy, the occurrence of residual cancer tissue (RCT) was evaluated as part of a prospective, nationwide trial in Denmark. RCT was defined by the presence of cancer left in relation to the biopsy cavity in the mastectomy specimen. A significantly higher cumulative recurrence rate within 3 yr was found in cases with residual cancer compared to cases without this finding. The difference was most pronounced in the premenopausal high-risk group. Therefore, RCT in the wall of the biopsy cavity is considered a prognostic hazard by itself.

Biopsy↗