Search PubMed⌕ Search

Biomedical subjects

J Kjaergaard

Publications and source records attributed to J Kjaergaard.

At least 55 records · Page 3Linked to original sources
PubMed1991

Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse. Double-blind comparative trial.

In a double-blind, parallel-group clinical trial of 195 patients with duodenal ulcers who after a short-term study had relief of pain and healed ulcers proved endoscopically, 65 were randomized to receive 20 mg omeprazole 3 days a week (once in the morning from Friday to Sunday), 64 to receive 10 mg omeprazole once daily in the morning, and 66 to receive placebo for up to 6 months. The patients underwent repeat endoscopy with biopsy of the gastric fundic mucosa (qualitative assessment of argyrophilic cell population), assessment of symptoms, and laboratory screening with measurement of basal serum gastrin concentrations at 3 and 6 months or more often if indicated by recurrence of symptoms. At 3 months, endoscopically proved ulcer relapse occurred in 16% receiving 20 mg omeprazole 3 days a week; 21% receiving 10 mg omeprazole daily; and 50% receiving placebo. At 6 months, corresponding rates were 23%, 27%, and 67% with 95% confidence intervals of difference between the placebo group and omeprazole groups of 28%-60% and 24%-56% (P less than 0.00001), respectively, and between omeprazole groups of -19%-11% (NS). No major clinical or laboratory side effects were noted. Thus both omeprazole regimens are effective and safe in preventing duodenal ulcer relapse.

Adolescent↗
PubMed1990

[Evaluation of the discharge summary by general practitioners. A questionnaire study].

In March 1986, a questionnaire investigation was sent to 250 general practitioners chosen at random in Denmark. In this questionnaire, general practitioners were asked about their assessment of the total activity involved in letters of discharge. Out of the practitioners questioned, 188 replied to the questionnaire (75.2%). 74% of the practitioners considered that changes were necessary in discharge letters. Most dissatisfaction was expressed about late receipt of discharge letters. 34% of the practitioners found that these letters should be received 0-3 days after discharge of the patient while 61% considered that 4-7 days after discharge could be accepted. A total of 92% considered that, on an average, they received letters of discharge later than seven days after discharge of the patient. As regards the contents of the letters of discharge, 68% of the practitioners considered that these were usually satisfactory. Practitioners appreciated substantial letters with emphasis on conditions of significance for the post-hospital treatment. The most important information was considered to be: medicine on discharge, information given to the patient, reasons for possible changes in medication, information about the subsequent treatment in addition to medicine and information about patho-anatomical findings at operation or biopsy. This investigation has provided a general consumer review of the form of discharge letters, the language, content, use and time of sending.

Denmark↗
PubMed1990

[Evaluation of the discharge summary by physicians in charge. A questionnaire study].

In September 1986, a questionnaire about letters of discharge was sent to 250 physicians-in-charge i 250 clinical hospital departments in Denmark. Out of these, 214 replied to the questionnaire (85.6%). Only 110 (51%) of the physicians-in-charge stated that there was a definite time (number of days) by which the letter of discharge should be sent after the discharge of the patient. In 99 departments (46%), the letters of discharge were, on an average, sent later than the physician-in-charge found acceptable. 50% of the physician-in-charge found that the acceptable time of sending the letter of discharge after discharge of the patient was 0-3 days. 43% of the physicians-in-charge found that 4-7 days after discharge of the patient could be accepted. Formalized teaching in writing letters of discharge only took place in 24 departments (11%). Only few physicians-in-charge stated that they often or fre quently received negative or positive feed-back from general practitioners about letters of discharge. The following concrete proposals to improve the quality of letters of discharge and to shorten the time until sending are discussed: simplifying the passage from dictation of the letter to dispatch, increased formalized teaching of house officers and generally higher priority for letters of discharge.

Denmark↗
PubMed1990

[Evaluation of the discharge summary by resident staff physicians. A questionnaire study].

In September 1986, a questionnaire about letters of discharge was sent to 250 house officers in 250 clinical departments in Denmark. Out of these 197 replied to the questionnaire (78%). 32% of the house officers found that an acceptable time for the general practitioner to receive the letter of discharge was 0-3 days after discharge of the patient, while 53% of the house officers found that 4-7 days time was acceptable. 23% of the house officers stated that they had now or previously received formalized teaching about how to write letters of discharge. 44% of the house officers stated that they never received criticism or advice about writing of letters of discharge from their physicians-in-charge. The house officers considered that the most important information in the letter of discharge was, in general: medication on discharge, recommended follow-up treatment apart from medicine, information about possible outpatient visits, pathological findings at operation or biopsy and information about the treatment during hospitalization. 88% of the house officers considered that the letter of discharge was a good form of communication. 29% of the house officers considered that alterations of the work in toto of the letters of discharge were necessary and remarked that this was particularly important as regards early dispatch of letters of discharge to general practitioners. A description of the function of letters of discharge as seen by house officers is attempted in this investigation.

Denmark↗
PubMed1990

[Cecostomy can not be recommended as a routine method in the treatment of acute left-sided obstructive colon cancer].

During a period of 17 years, 135 patients with acute left-sided obstructive cancer of the colon were admitted to two hospitals in the County of Copenhagen. Primary decompression by means of coecostomy was performed. The plan was to perform resection of the tumour after some weeks and colocolic anastomosis and closure of the coecostomy either spontaneously or operatively after some months. The total mortality was 24%. A total of 84 patients (62%) completed the planned therapeutic course, 21 without complications. Eighteen patients survived with permanent coecostomies. The mortality in this material was similar to those in materials where other therapeutic regimes were employed. The prolonged therapeutic programme and considerable morbidity thus do not result in reduction in the mortality. The authors cannot therefore recommend primary decompressive coecostomy. This method can only be recommended as an emergency measure under local anaesthesia for patients in such poor general condition that other forms of treatment are not possible.

Adult↗
PubMed1989

The influence of age upon the survival after curative operation for colorectal cancer.

From 1962 to 1982 1,623 consecutive patients were curatively operated for colorectal adenocarcinoma. For all patients cancer specific mortality rates were registered and the influence of the following prognostic factors was evaluated: tumour stage and grade, adenomas, age, sex and tumour site. In a multivariate Cox analysis, with backward elimination of non-significant factors at a 10% level, Dukes' C stage, poor differentiation, and age between 40 and 60 years at onset of carcinoma reached independent prognostic significance.

Actuarial Analysis↗
PubMed1989

Rectal anastomosis with application of luminal fibrin adhesive in the rectum of dogs. An experimental study.

By performing a colorectal anastomosis, the risk of a serious clinical leakage is about 10 percent. On the basis of this, the current study described a combined fibrin adhesive-sutured anastomosis in the rectum performed with interrupted seromuscular sutures externally and fibrin adhesive in the mucosa-mucosa cleft internally. Ten dogs having combined anastomosis were compared with ten dogs having a two-layer sutured anastomosis in the rectum as a control. The median bursting strength in the rectum seven days after the operation was 280 mm Hg (range, 180 to 340 mm Hg) for the combined anastomosis and 260 mm Hg (range, 170 to 405 mm Hg) for the sutured anastomosis in the control group. Two anastomoses with two-layer sutured anastomosis had a leak demonstrated radiographically, while no leakage was demonstrated in the ten dogs with combined anastomosis. In conclusion, intraluminal applied fibrin adhesive may contribute to the security of the sutured rectum-anastomosis.

Anastomosis, Surgical↗
PubMed1989

Randomized trial of fibrin adhesive for reduction of drained secretion after elective cholecystectomy.

Eighty patients scheduled for elective cholecystectomy were randomly allocated to application of fibrin adhesive (Beriplast) to the gallbladder bed or to a control group. No significant difference was found between the two groups in regard to amount of postoperatively drained secretion or in drainage time. Fibrin adhesive thus had no effect on secretion of peritoneal fluid after simple cholecystectomy.

Adult↗
PubMed1989

Healing of the fibrin adhesive anastomosis in the small intestine of pigs.

The healing of the fibrin adhesive small intestinal anastomosis from 1/2 to 168 hours postoperatively was evaluated by the bursting strength method in 28 pigs. There were no clinical leaks. After an initial increase in strength, from 1/2 to 48 hours postoperatively, the strength of the anastomosis dropped to a low at 96 hours postoperatively. From then on, a steady increase in strength was observed. A similar pattern of healing has been observed for the sutured intestinal anastomosis.

Animals↗
PubMed1988

Metronidazole versus placebo in the treatment of gaseous discomfort in patients having an ileostomy. A double-blind cross-over investigation.

In a double-blind, cross-over trial with metronidazole (Flagyl) 400 mg twice daily and placebo given to suitably adjusted ileostomy operated patients during two week periods, no significant reduction could be demonstrated in gaseous discomfort as measured by the number of bag emptyings per day, as well as gaseous symptoms in the form of the passage of flatulence from the stoma and borborygmi.

Adult↗
PubMed1988

Failure in prophylactic management of thromboembolic disease in colorectal surgery.

The operative courses of 294 elective consecutive colorectal resections were reviewed in order to evaluate the morbidity and mortality of postoperative thromboembolic complications. All patients received low-dose heparin prophylaxis. Fifty-seven patients were screened for deep venous thrombosis with the fibrinogen uptake test, and treatment of thromboembolism was started if the diagnosis was established by venography and/or pulmonary scintigraphy. Neither the morbidity nor mortality from clinical thromboembolic complications was lowered in the group of patients who were screened. Rectal surgery seems to carry a higher risk of postoperative thromboembolic complications than colon surgery, and thromboembolic complications are responsible for about half of the postoperative deaths following elective colorectal surgery.

Aged↗
PubMed1988

Evaluation of ileorectal anastomosis for the treatment of ulcerative proctocolitis.

Of 327 patients treated for ulcerative proctocolitis, 165 underwent surgery and an ileorectal anastomosis was performed in 59: 19 of these patients were operated upon in one stage and 40 in two stages. In 13 cases the anastomoses had to be converted, 5 during the initial hospitalization and 8 during a later admission. Three patients developed carcinoma of the rectal stump. The median follow-up period was 15 years. It is concluded that ileorectal anastomosis has a place in the treatment of inflammatory bowel disease, but requires careful follow up of the patients.

Anastomosis, Surgical↗