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Biomedical subjects

J Kelemen

Publications and source records attributed to J Kelemen.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Value of iopamidol in radiologic diagnosis].

The effect of the contrast medium Iopamidol/Iopamiro, Bracco (Milano) was studied in 31 patients via intravascular or intraarticular injection, as well as in experiments on dogs with 32 kidneys, employing selective angiography and histological examination. In all cases, we obtained good x-ray films showing plenty of detail, the patient tolerance being good. Blood pressure, pulse rate and UN, SGOT, and SeBi values did not show any significant change. In some cases we noticed a moderate proteinuria. In the animal experiments, the kidneys showed histological changes in two cases only which could be ascribed to the action of the contrast medium; however, even these changes were of a minimal nature and degree, and were reversible. Iopamidol was found to be a very favourable contrast medium as far as the kidneys are concerned.

Aortography↗
PubMed1984

Study of exercise induced bronchospasm by various loading tests.

In 378 children affected by asthma and 87 healthy children, physical loading was carried out by three kinds of test, viz. free running, stairstep test or skipping, and bicycle ergometry. In 32% of healthy children physical exercise led to improved respiratory function, while this value was only 7% in asthmatics. An improvement in respiratory function exceeding 20%, i.e. appreciable bronchial dilatation, never occurred in asthma patients. The bronchospasm of healthy children showed no consistent time course, in asthmatics it was most pronounced three minutes after exercise. Exercise induced bronchospasm occurred most frequently after free running, least frequently after ergometric loading. The stairstep test and skipping provoked exercise induced bronchospasm in a nearly identical proportion. Severity of exercise induced bronchospasm exhibited a similar distribution. In addition to cases with a positive response to running test, some of the other methods revealed further 5-6% of cases. Free running is the most suitable method for demonstration of exercise induced bronchospasm, ergometric loading appears the least sensitive test in this respect. By application of three loading tests exercise induced bronchospasm could be demonstrated in 52% of paediatric asthma patients.

Asthma↗
PubMed1983

Plasmapheresis with immunosuppression in amyotrophic lateral sclerosis.

Four patients with amyotrophic lateral sclerosis and one with progressive muscular atrophy were treated with large-volume plasmapheresis combined with immunosuppression. Assessment of muscle strength and functional ability was performed during a period of time ranging from 6.2 to 13 months. Patients were compared with a clinically matched control group. Both treated and untreated patients continued to show similar deterioration. The results of this study failed to show any therapeutic benefit of plasmapheresis with immunosuppression in patients with amyotrophic lateral sclerosis.

Amyotrophic Lateral Sclerosis↗
PubMed1983

Positive skin prick tests of immediate type in non-allergic children.

Prick tests with twenty different Beneard antigens were performed in 300 children aged 2-16 years, all having a negative individual and familial history for allergic disease. At least one positive result was obtained in 64% of the children and among the 6000 tests a total of 727 were positive. Of the positive tests 93% were + or ++, 7% were +++ or ++++. No relationship was found between age and the incidence of positive skin tests. Mild reactions against more than one antigen in the same individual were quite frequent, pronounced reactions (+++ or ++++) against more than one antigen were exceptional. The incidence of mild reactions was found to be independent of the gender; strong reactions occurred in girls twice as often as in boys. The highest incidence of positive reactions was observed with house-dust mite, pollens, hay and straw dust, and canine and feline hairs. The diagnostic value of mild positivity is slight but pronounced positivity, especially against more than one antigen, must carefully be considered and in any case followed by a bronchial provocation test.

Adolescent↗
PubMed1982

Familial granulovacuolar lobular myopathy with electrical myotonia.

We report 3 patients with a myopathy characterized by profound selective muscle wasting and weakness, electrical myotonia without clinical myotonia and an unusual muscle biopsy. Cryostat sections showed muscle fibers with vacuoles containing hematoxylinophilic granules, and 30% of type I fibers showed demarcation of their sarcoplasm into "lobules" due apparently to reorganization of myofibrillar elements. The electrical myotonia suggests an underlying muscle membrane defect. Two of the patients are siblings suggesting that the disorder may be inherited.

Adult↗
PubMed1982

Familial myoadenylate deaminase deficiency and exertional myalgia.

In 14 members of four families with a hereditary syndrome of exertional myalgia, five of eight muscle biopsies from symptomatic individuals showed histochemical and biochemical absence of myoadenylate deaminase (MADA). In the others, MADA biochemical activity was normal in two and reduced but not absent (intermediate level) in one. Asymptomatic relatives had normal histochemical MADA activity, but three had intermediate biochemical levels. In a survey of 302 routine muscle biopsies, 3 of 36 patient with myalgia had absence of MADA. Three of 266 biopsied for other conditions were MADA-deficient. Despite some inconsistencies, MADA deficiency seems to be relevant to this clinical syndrome.

AMP Deaminase↗
PubMed1982

The prognosis of severe bronchial asthma in childhood on the basis of late reexaminations.

Four hundred and forty one patients treated for asthma between 1954 and 1978 were reexamined. Their age ranged from 15 to 36 years at the time of reexamination. To regard a case as severe, at least four factors out of the following six had to be present: 1. Attacks more frequent than one every week; 2. attacks lasting for more than one day; 3. six or more hospitalizations; 4. absence from school exceeding one month per school-year; 5. drop-out from school for at least one school-year; 6. steroid treatment for more than one week. 59 patients (13.3%) fulfilled the criteria. The sex ratio within the severe group was 1:1 although there was a male preponderance of all asthmatics. The recovery rate for the severe group was lower (40.6%) than for all patients (75.0%). Prognosis was less favourable in female than in male patients. In the severe group the disease appeared earlier, eczema during infancy occurred more frequently and allergic disorders had a higher incidence in the family than in the group as a whole. Chest deformities were observed in 48.7% of severe patients while its incidence was only 18.6% for all patients with asthma. Acetylcholine-induced bronchial hyperactivity was more frequent in the severe patients than in all patients irrespective of the degree of severity while the prevalence of exercise induced asthma showed no relationship to the degree of severity. Among the severe cases 31% failed to cope with a standardized physical load.

Adolescent↗