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Biomedical subjects

J Kelemen

Publications and source records attributed to J Kelemen.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Clinical considerations on exercise-induced bronchoconstriction].

With 378 children suffering from asthma authors performed three types of physical exercises. The correlation between the exercise induced bronchospasm and the clinical symptoms of asthmatics, first of all the severity of asthma, has been investigated. No significant correlation was found between the EIB and age, sex, somatic development, start and duration of asthma and frequent respiratory infections. The seriously ill patients had more serious and frequent EIB. As practical conclusion it can be established that the examination of asthmatic children with exercise induced bronchospasm is important from the point of view of sports, but also in judging the severity of asthma.

Age Factors↗
PubMed1987

Results of bronchial challenge after infantile obstructive bronchitis.

The bronchial hyperreactivity was examined in a follow-up of 206 children having had obstructive bronchitis before two years of age. The acetylcholine challenge was done with 0.5% and 1% Pharmalgen solutions. The bronchial hyperreactivity was established over a 20% decrease of PEF and/or FEV1 values. Summarizing the results produced by 0.5% and 1% solutions a significant difference could be found in the bronchial hyperreactivity between the follow-up and control groups. Similarly the PC20 (provocative concentrations) values were suitable for differentiating the two groups. Upon physical exercise, EIB occurred in 2%. With the skin prick test (SPT) by 10 allergens 3+ or 4+ positivity was found in 17% of the children. Between the bronchial hyperreactivity and SPT positivity a significant correlation could be established.

Acetylcholine↗
PubMed1986

[Transcatheter embolization of the hypogastric artery in patients with tumors of the bladder and uterus].

In 31 patients (24 with urinary bladder carcinoma and 7 with gynaecological tumors) artificial embolisation of the hypogastric artery was effected using small spongy pieces of Gelaston or Spongostan or haemostyptic sponge. Uncontrollable bleedings supplied the indication for this measure. Bleeding stopped in 24 patients (19 tumours of the bladder and 5 gynaecological tumours) and was considerably reduced in 7 patients (5 bladder and 2 gynaecological tumours). Side effects in a major proportion of the patients consisted of pain or elevated temperature or fever lasting for several days. Our own experience has shown that embolisation of the hypogastric artery is a valuable method that does not expose the patient to the undoubtedly greater stress of an operation. Embolisation should be bilateral as far as possible and should be selective but not superselective.

Adult↗
PubMed1984

Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy.

Nine children with Duchenne muscular dystrophy were given Sanorex (mazindol), a growth hormone inhibitor, daily for 6 months. There was no significant change in their muscle function, but there was a significant reduction in weight gain and in levels of growth hormone, somatomedin C, hair zinc, serum zinc, and serum LDH. Selenium and glutathione peroxidase in the serum increased significantly. Thirteen other children with growth hormone deficiency had a significant reduction in hair selenium following growth hormone administration. These results show a significant relationship between growth hormone and selenium nutritional status and confirm our previous reports indicating an effect of growth hormone on zinc nutritional status. It is possible that prolonged therapy with a growth hormone inhibitor would attenuate the course and improve the longevity of patients with muscular dystrophy.

Adolescent↗
PubMed1984

Late prognosis of bronchial asthma in children.

The authors present data on the natural course of childhood bronchial asthma. They made a follow-up on 441 formerly asthmatic patients after the age of 14 years. The follow-up was based on questionnaires accompanied with personal interviews, physical examination, etc. The disease began in 167 (38%) patients before the age of 2; at the 'end' of childhood, at the age of 14, 34% were still asthmatic. In young adult age symptoms recurred in some cases and at the age of 26, 43% of the patients showed asthmatic complaints. The frequency of asthmatic attacks was significantly less in the young adults compared with that of childhood. Death occurred in 5 former patients, but only 2 of them died as a consequence of asthmatic disease. The authors constructed a diagram on the natural course of childhood asthma and show the practical use of this curve.

Adolescent↗
PubMed1984

[Abnormal renal angiograms caused by injection of contrast medium].

The anomalies caused by the injection of contrast medium were studied in animal experiments with dogs on 53 kidneys, and on clinical material, via the renal angiograms of 130 patients. In these trials vascular spasms were seen or, alternatively, filling defects in the parenchyma. Both were using the classical tri-iodated contrast medium iodamide and the monoacid dimeric contrast medium with low osmotic pressure (Hexabrix); in several cases, histological changes (for example, necroses of the tubular epithelium) were seen. Anomalous angiograms were also seen in the human experiments, especially in case of incorporation of large quantities of contrast medium and selective use of a thick catheter. Anomalies were more likely to occur in kidneys with diseased parenchyma.

Angiography↗