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Biomedical subjects

J Jakubowski

Publications and source records attributed to J Jakubowski.

At least 73 records · Page 4Linked to original sources
PubMed1973

Intracranial dissemination of pituitary adenomas.

Two unusual cases of pituitary adenomas giving distant secondary deposits inside the cranial cavity are presented. The authors comment on the accessible literature and the possible routes and cause of the spread. Finally they discuss the problematic nomenclature and classification of these tumours.

Adenoma↗
PubMed1972

Axial enlargement of the 3rd ventricle, and displacement of the brain-stem in benign aqueduct stenosis.

A personal series of 12 patients with benign aqueduct stenosis has been surveyed. A review of the radiographs has shown that in chronic aqueductal stenosis there is axial enlargement of the 3rd ventricle and displacement of the brain-stem. When these two features are pronounced, blockage of the basal cisterns will occur. We propose that when unsatisfactory flow of fluid through the basal cisterns may be inferred, then ventriculocisternostomy should be avoided. Evidence that the ventricular drainage is continuing satisfactorily after operation may be obtained either by echoencephalography, or by radiography, or by both means.

Adolescent↗
PubMedDate not supplied

An in vitro study of the pharmacological responses of rat middle cerebral artery: effects of overnight storage.

This study was designed to establish the in vitro pharmacological responses of rat middle cerebral arteries (MCA), and also their susceptibility to overnight cold storage at 4 degrees C. MCAs were harvested from rats and pharmacological responses were studied using a Mulvany myograph. Responses to prostaglandin F2 alpha (PGF2 alpha), uridine triphosphate (UTP), noradrenaline (NA) and histamine were determined to investigate receptor-dependent responses, sodium nitroprusside and papaverine to investigate receptor-independent relaxation and L-arginine and N omega-Nitro-L-arginine methyl ester (L-NAME) to examine nitric oxide synthase-dependent responses. Responses in fresh arteries were established and compared with responses in arteries which had been mounted on a myograph and stored overnight at 4 degrees C before study the next day. The MCAs had an effective lumen diameter of 263 microns (SD 25) and sustained concentration-dependent contractions were produced by 124 mM K+, PGF2 alpha, UTP and L-NAME. Sodium nitroprusside, NA, histamine, papaverine and L-arginine produced concentration-dependent relaxations in precontracted arteries. Overnight cold storage did not alter the pharmacological responses to any of the agonists tested.

Animals↗