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Biomedical subjects

J Jakubowski

Publications and source records attributed to J Jakubowski.

83 records · Page 5Linked to original sources
PubMedDate not supplied

[Hyponatremia after subarachnoid hemorrhage caused by ruptured intracranial aneurysm].

Hyponatremia developed both prior to and after surgery in 30.5% and 23.4% out of 164 patients with ruptured intracranial aneurysms. It was more frequent postoperatively in those patients in whom baseline serum sodium levels were lower. Hyponatremic patients were older than normonatremic. The mean difference in age was about 7 years. The authors, basing on CT scans, have found that hyponatremia development has been more likely in patients with blood visible in subarachnoid space, specially chiasmatic cistern, and patients with ventricular bleeding or hydrocephalus. Hyponatremia following subarachnoid hemorrhage seems to result from the ischemic lesions to hypothalamus i may, therefore, be considered as vegetative equivalent of so-called cerebrovascular spasm.

Adult↗
PubMedDate not supplied

[Various problems related to the occurrence of hydrocephalus after subarachnoid hemorrhage caused by ruptured cerebral aneurysm].

A CT scan done on admission showed widening of the ventricular system in 56 (34%) out of 164 patients with a ruptured intracranial aneurysm. 82% of the patients were admitted within 5 days after the bleeding. Those with hydrocephalus were often in a poor clinical condition (grades 3-5 Hunt and Hess, p less than 0.01) with up-going plantars twice as frequently encountered as in the remaining group. Widening of the ventricles adversely affected the prognosis. With hydrocephalus rebleeding was more frequent (p less than 0.02) and so was the ischaemic neurological deficit, whereas long-term treatment results were worse (p less than 0.01) with a double mortality rate (p less than 0.02). Hydrocephalus was more frequent in older patients (p less than 0.001 and in those with posterior fossa aneurysms (p less than 0.005). It was also promoted by diffuse and extensive bleeding into the subarachnoid space (p less than 0.01) and by intraventricular haemorrhage (p less than 0.0001). Three patients were treated with ventricular drainage.

Aged↗
PubMedDate not supplied

[Magnetic stimulation of the human nervous system. Theoretic basis and clinical application].

Magnetic stimulation of the nervous system is a new technique introduced in 1985 by Barker, Jalinous and Freeston. Using short pulses of a time-varying magnetic field it allows a noninvasive stimulation of the motor cortex and deeply placed peripheral nerves. The authors presented basic principles and applications of this method. Stimulation procedures were described and the problem of safety and possible side-effects was discussed. Advantages and disadvantages of the method were presented in comparison to electrical stimulation. Preliminary results of the clinical studies conducted chiefly in patients with multiple sclerosis and cervical spondylosis were reviewed.

Cervical Vertebrae↗
PubMedDate not supplied

[Studying somatosensory evoked potentials for the evaluation of surgical risk in patients operated on for aneurysms of the cerebral arteries].

In the light of an analysis of 31 patients operated upon in the Neurosurgical Department, Royal Hallamshire Hospital in Sheffield the authors tried to assess the usefulness of somatosensory evoked potentials for evaluating the surgical risk in patients with intracranial aneurysms. The analysed material was chosen so that it could be possible to eliminate the influence of factors connected with the operation on the condition of the patients after the operation. The analysis showed that in patients with low amplitude of N20 potential and prolonged CCT the per cent of insatisfactory operation results may be greater, especially in patients in group III of clinical condition according to the classification of Hunt and Hess (4), and CCT in the analysed group was found to be a slightly worse indicator of surgical risk than the amplitude of N20 potential.

Carotid Artery Diseases↗
PubMedDate not supplied

[Changes in the time of central neural conduction and of the amplitude of the potential N10 of the somatosensory evoked potentials in a model of subarachnoid hemorrhage in baboons].

On the ground of experiments on 6 baboons the authors tried to determined changes in the amplitude of the N10 somatosensory potential and the time of central neural conduction in relation to changes of the cerebral blood flow in subarachnoid haemorrhage. The following conclusions have been reached: the time of central neural conduction as well as the amplitude of the N10 cortical potential may serve as indicators of brain ischaemia after subarachnoid haemorrhage. The amplitude of the N10 potential seems to be an earlier indicator of ischaemia than the time of central neural conduction. The relationship of the changes in somatosensory evoked potentials and the brain blood flow is doubtless, but this relationship is not directly caused by changes in the cerebral blood flow.

Animals↗
PubMedDate not supplied

The case of TDI-induced reactive airway dysfunction syndrome with the presence of specific IgE antibodies.

Reactive Airways Dysfunction Syndrome defines a chronic, nonallergic bronchoconstriction syndrome due to a brief, single inhalation exposure to highly concentrated irritant factors. Here we describe a case history of RADS in patient exposed to isocyanates with the presence of specific IgE antibodies. According to some authors only RAST ratio > 2.0 is a criterion of an allergic origin or TDI-induced respiratory disease, and a lower ratio is believed to be a proof only of an exposure. Negative effects of bronchial specific provocative tests confirmed the insignificance of the IgE-mediated mechanism in RADS and on the other side emphasized the possibility of incorrect diagnosis of TDI-induced bronchospastic syndromes.

Bronchial Provocation Tests↗