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Biomedical subjects

J Jakubowski

Publications and source records attributed to J Jakubowski.

At least 55 records · Page 3Linked to original sources
PubMed1980

Primary plasmocytomas of the cranial vault.

Primary intracranial plasmocytomas are rare in neurosurgical practice. The accessible literature indicates that they fall into two groups: 1. Extramedullary plasmocytoma originating from the dura and 2. Plasmocytoma originating from the cranial vault. Four patients with primary lesions of the cranial vault were surgically treated and common characteristic clinical and radiological features discussed. Although the immediate outcome of treatment was excellent in all cases, the dissemination of disease occurred in two patients within the period of one year. It is therefore essential that the patients with so called solitary cranial plasmacytoma were rescreened for systemic myelomatosis at regular intervals.

Cerebral Angiography↗
PubMed1980

Difficulties in diagnosis of intracranial meningiomas by computed tomography.

The false positive and false negative computed tomography diagnoses of meningioma made using EMI 1010 and 5005 machines on a consecutive series of patients seen over a period of four years are described. About 1.2% of intracranial meningiomas were not detected on initial CT scan, 6.6% were misdiagnosed including 5.2% which were thought to be malignant lesions; in 9.4% of the cases identified as meningioma another diagnosis was subsequently established of which 6.3% were malignant.

Brain Neoplasms↗
PubMed1979

Surgical treatment of giant pituitary adenomas.

Multidirectional extension and invasive spread are important features of giant pituitary adenomas. Operability cannot be established merely by determining the size of the most prominent part of the tumour. Detailed radiological evaluation with plain films, computed tomography, angiography, and air studies all contribute to evaluation of the precise anatomy before surgery. In the final decision risks of surgical treatment must be balanced against the patient's age and prospects of long-term useful survival. Unfavourable cases for surgical treatment in our hands were those tumours embedded in the hypothalamus with thalamic and posterior extensions. Partial removal of such cases gave poor results. Where the mass proves soft, radical excision may be possible, but not otherwise. Limited biopsy for histological study, followed by a shunt procedure and x-ray therapy seems still the only recourse.

Adenoma↗
PubMed1979

Transcranial management of pituitary tumours with suprasellar extension.

A consecutive series of 101 pituitary tumours treated in the 10 year period 1968-78 has been examined, giant lesions being excluded. There were 48 female cases and 53 male, women predominating in the ratio of three to two in the age group 40-50 years and men showing a slight predominance in the age group 50-60 years. Most cases presented with visual deterioration which in 22 cases had been present for between one and two years, and in a further 22 for an even longer period, between two and 10 years. All patients underwent subfrontal craniotomy with mainly radical excision of the tumour followed by radiotherapy. The operative mortality was 0.99%. A system of grading of visual field defect has been described and used to compare preoperatively visual loss with postoperative visual recovery. Fifty-six per cent of cases returned to normal vision over the first two years, and a further 37% showed appreciable improvement in visual fields or acuity or both. Six per cent of cases showed no improvement in visual fields, and one patient died of postoperative deep vein thrombosis and pulmonary embolism. The degree of visual improvement has been correlated with the extent of visual defect, length of visual complaint, and size of the tumour. The importance of central and peripheral visual field analysis is emphasised yet again.

Adenoma, Acidophil↗
PubMed1979

Difficulties in diagnosis of supratentorial gliomas by CAT scan.

The false positive and false negative computed tomography diagnoses of glioma made using an EMI 1010 machine on a consecutive series of patients seen over a period of two years are recorded. About 1.5% of gliomas were not detected on initial CAT scan, 6.5% were misdiagnosed as benign lesions, and in 6.5% of the cases identified as glioma a non-malignant condition was subsequently diagnosed.

Brain↗
PubMed1978

Coincidental aneurysms with tumours of pituitary origin.

Angiographic studies on 150 pituitary adenomas and 33 craniopharyngiomas presenting for surgical treatment are reviewed. Eleven incidental silent aneurysms (four arising from the intracavernous and four from the supraclinoid carotid artery, and three from the anterior cerebral artery complex) are shown. Intracavernous aneurysms were also present in two acromegalic patients who had been treated previously with yttrium implantation. Although encasement of vessels by these tumours is unusual, the relevance of vascular abnormalities to surgical treatment is sufficient to justify routine magnification angiography.

Adenoma↗
PubMed1976

Cerebral blood flow changes in acute experimental haemorrhagic vasospasm.

Subarachnoid haemorrhage was produced in 26 dogs by injecting fresh homogenous blood into the cysterna chiasmatica. Two types of vasospasm were observed, firstly segmental arterial spasm closely related to the bleeding point and secondly generalized arterial vasospasm not directly related to the bleeding point and often occurring some way from the bleeding point. Reduction in CBF occurred in 61% of cases and was always accompanied by radiological vasospasm. However, in about one quarter of the cases with vasospasm there was no alteration in CBF.

Animals↗