The correlation between the frequency index of the left parietotemporal E.E.G., and cerebral blood flow determined by rheoencephalography, was studied in 20 normal children (aged 8 to 13 years), 24 normal adults (18 to 45 years), 15 normal elderly subjects (78 to 95 years), and 37 patients with pathological disorders. A significant correlation was found in each group between the E.E.G. frequency index and blood flow rate. The occupation times correlating with the flow were: rapid rhythms in children, alpha rhythms (negative correlation) in normal adults, slow rhythms (negative correlations) in elderly subjects, and slow rhythms (negative correlation) in patients with pathological disorders.

Adolescent↗

PubMedDate not supplied

Comparative study of cerebral vasoactivity in vascular sclerosis of the brain in elderly men.

Thirty-five elderly patients underwent a systematic series of cerebrovascular examinations. The patients were divided into three groups on the basis of clinical criteria: normal patients (Group 1), patients with sequelae of a previous stroke or with minor mental disorders (Group 2), and patients with arteriosclerosis dementia (Group 3). The vasomotor reactions of the cerebral arteries were investigated by estimating regional cerebral blood flow (133Xe clearance technique). The authors emphasize the existence of cerebral vasoreactivity in subjects with clinical symptoms of senile dementia. Furthermore, in each of the three groups of elderly patients, there seemed to be a lack of correlation between the clinical symptoms and certain specific vascular examinations.

Age Factors↗

PubMedDate not supplied

[Study of the cerebral circulatory resistance by the Döppler effect and rheography (author's transl)].

A correlation is made between the index of circulatory resistance given by ultrasonic flow-measurement and rheography. Patients with normal and increased blood pressure were studied. The characteristics of the transient and of the permanent ischaemic attacks are defined.

Aged↗

PubMedDate not supplied

[Pregabalin (Lyrica) and neuropathic pain syndromes].

Pregabalin is a novel central nervous system (CNS) drug with no interaction at benzodiazepine or GABA receptor. Its mechanism of action is correlated with its high affinity for the alpha/delta submit of the voltage-dependant CNS calcium channel. Pregabalin is rapidly absorbed with at least 90% bioavailable irrespective of dose, does not bind to plasma proteins and is excreted virtually unchanged by the kidneys. Pharmacokinetics are linear and predictable across the therapeutic dose range (150-600 mg/ day). Pregabalin is indicated, like gabapentin, in the treatment of neuropathic pain syndromes like post-herpetic neuralgia (PHN) and diabetic polyneuropathy (DPN). Efficacy in other neuropathic pain syndromes need further investigations. This paper emphasizes advantages and disadvantages on a clinical point of view.

Absorption↗