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Biomedical subjects

J Jacquy

Publications and source records attributed to J Jacquy.

At least 73 records · Page 4Linked to original sources
PubMed1983

Regional cerebral blood flow and lateralized hemispheric dysfunction in depression.

Cerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

Adult↗
PubMed1980

Relationship between the electroencephalogram and the rheoencephalogram in the normal young adult.

The REG technique permitting an estimation of the grey matter flow was applied in conjunction with the simultaneous recording of the EEG analysed by the SULG manual method with 21 normal adult subjects. A relationship was established between the REG index and the EEG frequency index in a resting situation with eyes closed. An increase of the REG index was observed when the eyes were open, for looking at a picture and during a test of visual attention. At opening of the eyes a delay is observed between the desynchronisation of the EEG and the increase of the REG.

Adolescent↗
PubMed1978

Comparative study of the clinical effects of vincamine + glycerol versus glycerol + placebo in the acute phase of stroke.

The treatment of the acute phase of stroke creates a difficult problem to the clinician. The presently used drugs lead to controversial results. The progress in knowledge of the pathogenesis of cerebral damage underlines the determinant role of the metabolic deficits in the ischemic areas. The effect on the clinical symptomatology of patients in the acute phase of stroke was studied during a double-blind comparative clinical trial with an alcaloid of Vinca minor (Pervincamine) which acts favorably against disturbances of oxydative glucose metabolism and of cerebral microcirculation. 20 patients divided into two homogeneous groups received during 5 days either Pervincamine (4 ampoules of 3 ml = 60 mg vincamine p.d.) + glycerol, or glycerol + placebo administered by i.v. infusion. Clinically the results indicate a greater improvement of the neurological status (objectivated by a neurological scale) with vincamine treatment than with placebo. Statistically the analysis confirms the highly significant effect of vincamine on motility of lower and upper limbs (p less than 0.02) and the significant effect on cranial nerves (homonymous hemianopsia and conjugated deviation of eyes) (p less than 0.05) and on the sphincter control level (p less than 0.05).

Adult↗
PubMed1977

Regional cerebral blood flow in children. A rheoencephalographic study of the modifications induced by reading.

Cerebral impedance changes (F changes) indicating cerebral blood flow were studied in 17 children aged 6-11 years and in 10 normal adults. At rest, large values were found in children, who never exhibited the 'hyperfrontality' pattern of the adults. Reading induced an F increase in both the dominant and non-dominant hemispheres, in contrast with a larger increase in the dominant hemisphere in adults. A spatial test was designed in adults which triggered a larger increase in the non-dominant hemisphere.

Adult↗
PubMed1977

Myotonic dystrophy with nerve hypertrophy. Report of a case with electrophysiological and ultrastructural study of the sural nerve.

A striking enlargement of peripheral nerves was observed in a patient with myotonic dystrophy (Steinert's disease). Clinical findings disclosed a polyneuropathy which was confirmed by electrophysiological and morphological investigations. Myopathic as well as neurogenic alterations were found on electromyography in wasted hand muscles. The prominent finding on ultrastructural study of sural nerve biopsy was an important collagen infiltration with rather few "onior bulb" formations. This extensive endoneural collagen formation appeared to be responsible for the nerve hypertrophy. Evidence of segmental demyelination and remyelination was also found. Glycogen deposits were present in some myelinated axons and is some Schwann cells. Peculiar crystalline inclusions were observed in fibroblasts processes. The relation between myotonic dystrophy and polyneuropathy remains a matter of discussion.

Electromyography↗
PubMed1977

Regional cerebral blood flow during voluntary movements of the hand. A rheoencephalography study.

Cerebral impedance changes (F changes) indicating cerebral blood flow variations in the central and precentral areas were measured with a rheographic technique in normal subjects preparing for and carrying out a motor task. The time course of the F changes was studied and several significant correlations were established between the amount of F changes, their distribution and the motor performance. Our findings confirm that frontal and premotor regions play an important part in decision making.

Adult↗
PubMed1975

Regional cerebral blood flow variations in mental alertness.

The state of mental alertness preceding a motor task is accompanied by an increase in cerebral blood flow. During the first trials, these changes seem to be chiefly related to ascending reticular impulses. Habituation lateralizes and focalizes changes which are probably due to metabolic modifications in selective expectancy. The factor E of Eysenck seems to have some correlation with the individual variations observed.

Adult↗