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Biomedical subjects

J J Pindborg

Publications and source records attributed to J J Pindborg.

At least 91 records · Page 5Linked to original sources
PubMed1986

Yeast organisms associated with human oral leukoplakia.

Oral leukoplakia is a lesion of variable clinical behaviour and a malignant transformation rate of 3-6%. Leukoplakia exhibits various histologic features, hyperkeratinization being the most consistent. As yeast organisms have been encountered in a high proportion of leukoplakia cases, a causal role has been suggested for these organisms. Candida albicans is by far the most commonly isolated yeast from leukoplakia, but also other Candida species as well as Torulopsis and Saccharomyces species may be encountered. The species composition of the mycoflora in leukoplakia does however not differ from that of normal oral mucosa. Subspecies differentiation of C. albicans has revealed the existence of different oral strains between individuals and further, strain differences of C. albicans in leukoplakia and in normal mucosa have been observed. This procedure may lead to isolation and identification of the yeast organisms causally associated with leukoplakia.

Candida↗
PubMed1986

Oral health care: more than caries and periodontal disease. A survey of epidemiological studies on oral disease.

A review is presented of the epidemiology of the common oral diseases other than dental caries and periodontal disease. It appears that conditions, such as masticatory dysfunction, traumatic dental and maxillofacial injuries, impactions and oral mucosal disease each normally affect one-quarter to one-half of populations examined. To plan and achieve total oral health care, it is, therefore, necessary to take these conditions into account. As no study to date appears to have registered the total oral health care needs for a given population in either developing or industrialized countries it is suggested that such investigations should be undertaken now by WHO and/or FDI. Only when this total information is at hand can a rational oral health policy be developed.

Humans↗
PubMed1986

An intervention study of tobacco chewing and smoking habits for primary prevention of oral cancer among 12,212 Indian villagers.

In a house-to-house screening survey, 12,212 tobacco chewers and smokers were selected from the rural population in the Ernakulam district, Kerala state, India. These individuals were interviewed for their tobacco habits and examined for the presence of oral cancer and precancerous lesions, first in a baseline survey, and then annually, over a five-year period. They were educated using personal and mass media communication to give up their tobacco habits. The control group was provided from the results of the first five years of a 10-year follow-up study conducted earlier by the authors in the same area with the same methodology but on different individuals without any educational intervention. The stoppage of the tobacco habit was substantially higher in the intervention group (9.4%) compared to the control group (3.2%). A logistic regression analysis showed that the behavioural intervention was helpful to all categories of individuals, however, the effect was different for different categories: intervention was more helpful to men, chewers, and those with a long duration of the habit. These individuals rarely quit their habit without intervention.

Adolescent↗
PubMed1986

Detection of oral cancer using basic health workers in an area of high oral cancer incidence in India.

In the rural health care delivery system in India, basic health workers (BHW) go house-to-house to help in the preventive and therapeutic measures of certain diseases. Some 53 BHW were trained by the dentists of the research team for examining the oral cavity of high-risk individuals and categorizing them into normals or those with referable or nonreferable lesions. Referable lesions comprised nodular leukoplakia, submucous fibrosis, and ulcers and growths suggestive of oral cancer. In a 1-year period, 39,331 high-risk individuals were examined by BHW and 523 (1.3%) were referred for further diagnosis. Some 72% arrived at the referral center and 20 oral cancers were confirmed among these individuals. Reexamination in the field by the dentists was conducted for 5% of the sample to obtain sensitivity and specificity estimates of BHW diagnosis. The findings indicate that incorporation of an oral cancer detection program in the existing health care infrastructure is feasible and beneficial.

Allied Health Personnel↗
PubMed1985

Malignant transformation rate in oral submucous fibrosis over a 17-year period.

Sixty-six patients with oral submucous fibrosis were followed-up for a period of 17 yr (median observation 10 yr) in Ernakulam District, Kerala, India. Oral cancer developed in five (7.6%) patients. The malignant transformation rate in the same sample was 4.5% over a 15-yr observation period (median 8 yr). These findings impart a high degree of malignant potential to this condition.

Adult↗
PubMed1985

Subjectivity in evaluating oral epithelial dysplasia, carcinoma in situ and initial carcinoma.

During the 2nd Meeting of the International Association of Oral Pathologists in Amsterdam (1984), an exercise was held to study subjectivity in evaluating oral epithelial dysplasia. A poster with 9 color photomicrographs was presented to be evaluated anonymously by the participants. A total of 72 submitted diagnostic suggestions. In Table 1 these suggestions are given together with the diagnosis by the authors. A surprisingly wide spectrum of diagnostic suggestions was found indicating the need for an internationally accepted set of criteria for oral epithelial dysplasia.

Adolescent↗
PubMed1985

Relation of blood group carbohydrates to differentiation patterns of normal and pathological odontogenic epithelium.

The distribution of epithelial cell surface antigens was studied in normal odontogenic epithelium from 20 fetuses and in odontogenic epithelium from 15 ameloblastomas, 16 odontogenic keratocysts, 15 follicular and 15 radicular cysts. The cell surface carbohydrates were detected using antibodies with reactivity for the blood group antigens A, B, H type 2 (A and B precursor) and N-acetyllactosamine (N-lac, H type 2 precursor) by an immunofluorescence technique. The expression of the blood group carbohydrates differed considerably in normal fetal odontogenic epithelium from that in ameloblastomas and odontogenic cysts. The A, B and H type 2 antigens were demonstrated in odontogenic keratocysts and in follicular and radicular cysts. Expression of the blood group carbohydrates was similar in follicular and radicular cysts but differed from that seen in odontogenic keratocysts by the failure to detect N-lac in the latter. The antigens A, B, H type 2 and N-lac were not expressed in any of the ameloblastomas including types with palisading of basal cells and polarization of basal cell nuclei and types with a plexiform pattern with cuboidal or polyhedral shaped peripheral cells. The findings indicate that epithelium of ameloblastomas can be distinguished from odontogenic cyst epithelium by differences in expression of cell surface carbohydrates with blood group specificity.

ABO Blood-Group System↗