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Biomedical subjects

J Horn

Publications and source records attributed to J Horn.

At least 127 records · Page 7Linked to original sources
PubMed1980

[The role of the complement system in experimental pancreatitis (author's translation)].

Two different experimental procedures were used to induce pancreatitis in rats: distal ligature of the common bile duct and the Pfeffer method in modification of Nevalainen. It could be shown that consumption of complement can be demonstrated even in pancreatitis induced by other than immunological models. Further examination in decomplemented rats showed the possibility of inducing acute pancreatitis by the above-mentioned models, although of less intensity. Therefore, the complement system will be an important factor for the progress and intensity of the inflammation process.

Acute Disease↗
PubMed1980

[Intraluminal hypertension as a pathogenetic factor of acute pancreatitis in the rat (author's transl)].

By the use of various experimental procedures with rats, the significance of intraluminal hypertension, caused by ductal obstruction, reflux of bile and duodenal reflux were considered with regard to their capacity for producing pancreatitis. The extent of the histological changes in the pancreas after 48 hours as well as the period of survival in the individual experimental groups served as the parameters for the comparison. The results show that the rise in intraluminal pressure is alone enough to produce acute pancreatitis. It follows from this that rise of pressure in the duct system caused by ductal obstruction may be the triggering factor in the induction of pancreatitis. Reflux of bile, bacterial colonisation of the pancreas by duodenal reflux as well as activation of proteolytic enzymes were not necessary a prior factors but ones which have an aggravating effect in the development of the disease.

Acute Disease↗
PubMed1979

A double-blind trial of synthetic salmon calcitonin in the treatment of acute pancreatitis.

A multicenter randomized double-blind trial on the use of synthetic salmon calcitonin (SCT) was carried out in 94 patients with acute pancreatitis. In addition to strict standard treatment--without aprotinin, atropine, or antacids--50 patients received daily 3 x 20 micrograms = 300 MRCU SCT intravenously and 44 patients received placebo for 6 days. Mortality rate was not influenced, overall mortality being 5.3%. The number of patients without pain and with normalized serum amylase on a given day was significantly higher in the group treated with SCT. Other parameters such as doses of analgesics, leukocyte count, and normalization of seven defined clinical and laboratory criteria within 6 days showed a positive trend without reaching significance.

Acute Disease↗
PubMed1979

[Significance of the complement system in acute pancreatitis in rats].

The influence of complement system in acute pancreatitis in the rat was examined. Two different experimental procedures were used to induce pancreatitis: distal choledochal ligature and the Pfeffer model as modified by NEVALAINEN. In both procedures an acute pancreatitis developed and complement depression was noted. These results showed that consumption of complement will occur even in pancreatitis induced by other than immunologic models. In a second series the same experimental procedures were used in rats that had been decomplemented by application of cobra venom factor. It was possible to produce an acute pancreatitis of moderate severity.

Acute Disease↗
PubMed1978

[Duodenal ulcer of foreign workers (author's transl)].

A comparative study of the patients with a duodenal ulcer in our clinic in the past 3 years has shown a greater incidence of the disease in foreign workers in Germany, aged between 20 and 30 years. This difference concerns men as well as women. The consequences of this kind of ulcer and the possibilities of an indication for operation are discussed in detail.

Adaptation, Psychological↗
PubMed1978

Excretion of urea by the foetal guinea pig.

1. The placental transfer of urea was studied by perfusing the guinea-pig foetal placenta in situ with dextran solutions containing various amounts of urea, and radioactively labelled urea. 2. Transfer of urea was linearly related to the difference in concentration between the maternal and the foetal sides of the placenta, but transfer in both directions across the placenta was equal when the concentration of urea in the perfusing fluid was 2.5--3.5 mmol/l less than the maternal arterial value. This suggested that urea may be transferred against a concentration gradient. 3. Foetal plasma urea concentrations were found to be 0.5 mmol/l less than the maternal, suggesting that active transfer from the foetal circulation to the maternal can occur. However, because of the close relationship between foetal and maternal plasma urea (r = 0.96), it is concluded that the major control of foetal urea concentrations is by diffusion of urea between maternal and foetal extracellular fluids.

Animals↗
PubMed1977

[Dispensary control and rehabilitation of surgically treated patients with bronchial carcinoma in the region of Berlin (author's transl)].

Among 1813 persons with bronchial carcinoma in the years 1970-1974 475 were treated with surgery; more than 85% being older than 60 years. 299 of these patients had a survival time of at least 12 months. 64.9% of them received a cardiac treatment, 7.7% were only followed up. Bronchial infections were more common in these patients than in the average Berlin population. Among the 207 patients who had a survival time of more than 12 months at the end of 1974 56 were working; 41 from the 74 patients belonging to the age group younger than 65 years, 15 from the 133 patients belonging to the age group older than 65 years (pensioners). General recommendations concerning systematic controlled care should be given for persons resected for bronchial carcinoma. Systematic cardiac treatment should be provided.

Adult↗
PubMed1976

[Preliminary observations on the clinical use of calcitonin. Treatment and postoperative prevention of pancreatitis].

Calcitonin was administered to 4 patients presenting with acute pancreatitis as well as to 6 patients presenting with postoperative pancreatitis. Prophylactic administration was performed in 3 cases consecutive to pancreatic interventions. Following calcitonin all patients showed considerable improvement of clinical course. Although 8 patients recuperated completely 2 patients died from independent complications. After prophylactic administration of calcitonin the postoperative course was uncomplicated without demonstrable increase in serum amylase. It is emphasized that only early case histories are reported; their verification will depend upon the results of a controlled survey presently being performed.

Acute Disease↗
PubMed1976

[Modification of postoperative intestinal atony using caerulein. Comparative studies in the rat and man].

The effect of caerulein upon postoperative enteral paralysis was investigated in animals and men. The increase in motility effected by cerulein in rats was proved by the increase in passage demonstrated after administration of radioactive test food (51CrO4Na2 solution). A clinical survey comprising 20 patients in the postoperative period following cholecystectomy, compared to an untreated control group, confirmed our findings.

Animals↗