Biomedical subjects
Publications and source records attributed to J Hoffmann.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Sterilization of the fallopian tube via a laparoscope is being performed with increasing frequency. A rare but serious late complication of this procedure is tubal torsion, which occurs especially after monopolar electrocoagulation where the mesosalpinx is extensively damaged. We present a case in which this complication occurred after bipolar electrocoagulation.
Light reflected from the human heart surface was used to determine mixed hemoglobin and myoglobin oxygen saturations (O2SAT) in the cardiac tissue. The measurements were performed in 8 patients with coronary heart disease including stenosis of left anterior descending coronary artery (LAD) who underwent aorto-coronary bypass surgery. At the end of the operation the O2SAT was measured in the supply area of the LAD either with patent or occluded coronary bypass. In 13 experiments occlusion of the bypass resulted in a decrease of O2SAT from 74 +/- 16% to 61 +/- 24% (p less than 0.02). A new technique is introduced and its limitations are discussed. Preliminary results of application in coronary bypass surgery demonstrate an increase in tissue oxygenation following myocardial revascularization.
Explore the source record for details and available documents.
A prospective, randomized, controlled trial was performed to study truncal vagotomy and drainage (TV), selective vagotomy and drainage (SV) and parietal cell vagotomy (PCV) as elective treatment for duodenal ulcer. Five years postoperatively, 233 patients were available for study: 73 TV, 81 SV and 79 PCV. The ulcer recurrence rates were 13.6, 19.8 and 30.4 per cent respectively. The incidence of severe dumping was 4.9, 10.9 and 1.9 per cent; of severe diarrhoea 4.9, 6.3 and 1.9 per cent; of severe pain/dyspepsia 3.3, 6.3 and 3.8 per cent and of severe nausea/vomiting 0, 1.6 and 0 per cent respectively. Women suffered more postvagotomy symptoms than men. After treatment of recurrences and postvagotomy symptoms, more patients after PCV achieved excellent results than after TV and SV, as recurrences were easier to treat than severe postvagotomy symptoms. The only factor found contributing to the high ulcer recurrence following PCV was the large number of surgical trainees operating in the trial.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
For a nearly constant light scattering coefficient a method is presented which allows the quantitative analysis of reflection spectra of the brain using a nonlinear multicomponent analysis ( NLMCA ).
Explore the source record for details and available documents.
Over a 17-year period, all patients presenting with acute obstruction of the left colon due to carcinoma were treated by emergency tube cecostomy. There were 57 patients aged between 35 and 93 years. After the decompressive procedure, eight died, 34 had complications, and eight were left with permanent cecostomies. Forty-one underwent secondary procedures of which 35 had resections. Seven patients died postoperatively and 15 had complications. Of the 34 survivors, in 23 the cecostomy closed spontaneously, and 11 had operative cecostomy closure. Of the latter, four died postoperatively, and nine had complications. Thus, 30 survived the entire treatment program. Reasons for the high morbidity and mortality are discussed. Comparison is made with other forms of treatment in the literature. A treatment program is suggested, using tube cecostomy for poor-risk patients and primary resection without anastomosis for patients in better condition.
Forty-nine patients had conservative treatment of an appendix mass without interval appendectomy. Five were lost to follow-up within 6 months, and 44 patients were followed for between 6 months and 22 years. In nine patients (20 percent) recurrent appendicitis developed, and six (14 percent) suffered chronic pain not thought to be due to appendicitis. Of the recurrences, 66 percent occurred within 2 years of the initial attack. Barium examination of the cecum was successful in diagnosing two of three additional patients in whom a right iliac fossa mass was not due to appendicitis. The morbidity and expense of routine interval appendectomy was thus eliminated in 80 percent of the patients.
We have presented six instances of Dieulafoy's lesion, two of which were diagnosed endoscopically preoperatively. Endoscopic electrocoagulation was used in two instances, one with success, and this may have a place in the treatment of these lesions. Oversewing alone of the lesion seems to be sufficient surgical treatment, if nonoperative measures, such as selective arterial embolization or endoscopic electrocoagulation fail or are unavailable.
A 66-year-old woman with long-standing systemic sclerosis presented with fever, acute abdominal pain and tenderness. She was treated with antibiotics. At laparotomy six weeks later, a narrow, stiff, friable and fibrotic right colon was found with histological features of scleroderma. The acute attack was interpreted as an ischaemic episode of the colon which later healed by fibrosis.
Explore the source record for details and available documents.
The influence of thrombin inhibitors, which differ both in their chemical structure and type of inhibition on thrombin-induced microthrombosis was studied in rat lungs. The antithrombotically effective doses and blood levels of the compounds correlated with their kinetic constants for inhibition of thrombin. In preventing microthrombosis, some of the synthetic inhibitors tested surpassed the effectiveness of heparin and approached that of the naturally occurring inhibitor hirudin.