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Biomedical subjects

J Hoffmann

Publications and source records attributed to J Hoffmann.

At least 271 records · Page 15Linked to original sources

Antrectomy for recurrent ulcer after parietal cell vagotomy.

The results of antrectomy for recurrent ulcer after parietal cell vagotomy are reviewed. Eighteen patients underwent precise antrectomy between 6 months and 7 years after their primary operation. Fourteen patients were reconstructed with a gastroduodenostomy and 4 with a gastrojejunostomy. Eighteen patients were available for follow-up of between 18 months and 10 years. One patient (6.25 per cent) developed a recurrent ulcer 1 year after antrectomy. There was no operative mortality. Six patients (33 per cent) had minor complications in the immediate postoperative period, and one (5.5 per cent) had a major complication. According to Visick grading, 75 per cent had good or excellent results and 25 per cent poor results. Antrectomy following parietal cell vagotomy can be achieved with a low operative mortality, a low ulcer recurrence rate and a satisfactorily low incidence of post-gastrectomy problems.

Adult↗

[CT-guided celiac plexus block with ventral approach].

A modified procedure for infiltrating the coeliac plexus for the treatment of chronic pain syndromes is described. The injection of the analgesic is made through a fine needle introduced via a transabdominal approach under CT guidance. The advantages of this technique, compared with the dorsal approach, are a more accurate placement of the solution and the ability to carry out this procedure in very sick patients. No complications have been observed.

Abdomen↗

Unsuccessful experience with closure of Jaboulay gastroduodenostomies in the treatment of post-vagotomy dumping and diarrhea.

Eight patients after vagotomy and Jaboulay gastroduodenostomy had their gastroduodenostomy closed to treat dumping and diarrhea. Eight gastroduodenostomies were closed once and four were closed twice, a total of 12 procedures. Of these, ten were "simple" closures (direct suture of the opening into the duodenum via a gastrotomy) and two were "formal" (gastroduodenostomy formally dismantled). Among those gastroduodenostomies closed "simply," the closure remained intact for 2 to 9 months, relieving the patients' symptoms. Thereafter, the suture line broke down, leaving the patient with a patent gastroduodenostomy and recurrent symptoms. The two patients closed "formally" developed severe complications: one patient's stomach failed to empty permanently after the procedure and the second developed a duodenal leak. In addition to these major complications, another four of the 12 procedures were followed by transient gastric retention, and five of the 12 procedures were accompanied by minor pulmonary and wound complications. A satisfactory result was not achieved in any patient.

Adult↗

Correlation of field potentials with redox-states of cytochromes recorded from the olfactory cortical slice of guinea pig.

Field potentials and the reflection spectra of cytochromes were continuously recorded from the olfactory cortical slice of a guinea pig which was incubated under the normoxic and anoxic conditions. The reduction of the oxidated spectra of the cytochromes occurred before the decrease of field potential heights and the oxidation of the reduced spectra occurred before their recovery. In a 3 min anoxic experiment, a 90% recovery of the cytochromes aa3, b, and c, and the field potential amplitudes took place in this order after the restoration of oxygen.

Action Potentials↗

Rectal temperature in the diagnosis of acute lower abdominal pain.

The accurate diagnosis of acute lower abdominal pain continues to be a problem. In Israel, a diagnostic sign often sought as indicating pelvic peritonitis is a rectal temperature of greater than 1.0 C higher than the simultaneous oral temperature. We established that in each of the 20 emergency rooms surveyed both oral and rectal temperatures are measured as part of the admission procedure for patients with acute lower abdominal pain. The charts of three groups of 100 patients with acute lower abdominal pain were studied retrospectively. A rectal temperature of greater than 1.0 C higher than the oral was found in about 10% of each group. Both oral and rectal temperatures were raised in 56, 69 and 37% of each group, respectively. The rectal temperature alone was elevated in 8.5% of patients with appendicitis or pelvic inflammatory disease (PID), as well as in 6% of patients with undiagnosed abdominal pain. Oral temperatures alone were elevated in 4.5% of patients with acute appendicitis or PID and also in 13% of patients with undiagnosed abdominal pain. These differences were not significant. We conclude that the common Israeli practice of measuring both rectal and oral temperatures in patients with acute lower abdominal pain gives no more information than the measurement of either one.

Abdomen, Acute↗

[Pulmonary effect of inhaling leather-impregnation sprays (author's transl)].

After inhaling a leather-impregnation spray in a confined space, coughing fits and dyspnoea occurred in a 40-year-old man and an 20-year-old woman, previously in good health. The cardinal symptoms on admission to an emergency ward were of interstitial pulmonary oedema in the X-ray but without increased pulmonary arterial pressure. Administration of corticosteroids both by aerosol and intravenously improved the acute symptoms within a few hours. Two subsequent chest X-rays demonstrated complete healing. The acute symptoms were caused by the impregnation spray producing an alveolitis or toxic lung oedema in both cases. The early topical administration of corticosteroids would appear to be the most important preventive and protective measure.

Adult↗

A comparison of suprapubic and transurethral drainage for postoperative urinary retention in general surgical patients.

Percutaneous suprapubic bladder drainage, using an indwelling Silastic catheter, was compared with transurethral catheterization for the management of postoperative urinary retention in general surgical patients. In a prospective controlled trail, the overall incidence of postoperative retention was 7%. The urinary infection rate was 70% with transurethral catheterization and 8% with suprapubic drainage. Patients accepted suprapubic damage much more readily than transurethral cateterization and both medical and nursing personnel found the former method easier to manage effectively. Also, the patients' ability to pass urine spontaneously could be assessed without removing the catheter. However, minor mechanical complications were more common with suprapubic drainage. The cost of the two systems is comparable. We conclude that the routine use of suprapubic catheter drainage in the management of postoperative urinary retention significantly reduces the incidence of infection and is the preferred method of treating this common complication.

Bacterial Infections↗

[Combination of beta-receptor blocking agents and saluretica in outpatient treatment of hypertension. Results of a comparative study (author's transl)].

In a randomized single-blind study a comparison was made between the blood pressure lowering effect and the tolerance of two different combinations of beta-blockers and diuretic agents, one of the combinations being given in a sustained-release form. The study was made in 60 out-patients suffering from hypertension of the severity degrees I and II (WHO). The blood pressure reduction achieved as well as the diminution of the increase in heart rate and blood pressure under ergometric load proved to be almost equal in both groups. The number of patients whose blood pressure was normalized by the end of the study was larger in the group treated with Cardiotensin. The influence on laboratory parameters was only minimal and without clinical relevance. Both preparations have generally been well tolerated and exhibited an equal duration of effect.

Benzothiadiazines↗