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Biomedical subjects

J Heinrich

Publications and source records attributed to J Heinrich.

At least 253 records · Page 14Linked to original sources
PubMed1986

[Significance of internal tocography and intrapartal tocolysis in the management of labor].

The quantitation of uterine activity in 5,611 deliveries shows the following frequency of tocographic alarm criteria: high amplitude of labour greater than or equal to 11 kPa (82.5 Torr), 3.1%; high frequency of labour greater than or equal to 6 labours/10 min 4.6%; total contraction area greater than or equal to 40 kPa-min (300 Torr-min/10 min) 5.4%; high uterine basal tonus greater than or equal to 4 kPa (30 Torr) 0.9%; irregularity of labour 3.5%. In 70% the uterine hyperactivity is the reason for pathological FHF-patterns which induced an intravenous bolus injection of 25 micrograms Partusisten or an automatic continuous infusion before operative delivery. A second retrospective report covers 8,895 deliveries with a rate of 26.9% betamimetic treatments (preterm 41.5%) and only 8.1% pathological FHF-patterns. The low incidence of acidosis in the umbilical arteria (pHNA less than 7.10) of 2.6% in preterm and 0.6% in term newborn is caused by our obstetrical management including elective foetal monitorings and consistently realized betamimetic treatment during labour.

Female↗
PubMed1986

[Telemetric labor monitoring using the fetal monitor BMT 941-1].

Recommendation of a telemetric system for the direct fetal monitoring using the monitor BMT 914-1 (Zwönitz). The free movement of parturients during labor is more comfortable and involves an increasing uterine activity, a labor progress and a decrease of oxytocic infusion rate.

Electrocardiography↗
PubMed1986

[Cryosurgical treatment of cervical intraepithelial neoplasia following cervical smears and curettage].

65 patients exhibiting colposcopically and cytologically atypical epithelium in the cervix were treated by cryosurgery with liquid nitrogen. 63 of whom were confirmed histologically after surface scraping and curettage of the cervix. The patient then were followed cytologically and colposcopically 8 and 12 weeks after cryosurgery. According to that the definitive histological diagnosis was performed after conization (48 patients) hysterectomy (12 patients) and surface scraping and curettage of the cervix (8 patients). Colposcopical, cytological and histological findings after surface scraping of the cervix showed a correlation rate in the 95% range. Treatment failure rate following cryosurgery showed an increased percentage with increased grade of CIN. A complete destruction of ectocervical pathologic tissue in CIN 1 and 2 is opposed to a persistent disease rate of 20 percent in patients with CIN 3. The failure rate was significantly higher in cases without fully visualization of squamocolumnar junction. Cytological follow-up predicted all cases with histologic diagnosis of persistent disease. Colposcopical evaluation was frequently unsatisfactory after cryosurgery. Cryosurgery of CIN should be reserved for the treatment of those patients in whom the criteria for patient selection are performed and the benefits of this method outweigh the possible drawbacks.

Carcinoma in Situ↗
PubMed1986

[New aspects in improved management of labor].

The increase of obstetric operating frequency observed in the last years is to attribute to a better recognition and valuation of maternal and fetal risk and on the other hand to a false interpretation of cardiotocography. With respect to induction and management of labour from a lot of partly controversial opinions is the following to conclude for the practice: Utilisation of all diagnostic possibilities including fetometry, pelvimetry, and cervical ripeness. Therapeutic arrangement should include cervical ripening, mobilisation of patient and labour timing depending on internal tocometry. The operative delivery is to consider as an ultima ratio. Labour management can be optimated by means of a clinic-specific partogram considering the active phase. Every indicated induction of labour demands internal tocometry. The pharmacological control of uterine activity must be used differentially. It must be waited for, if the quantification of labour activity improves the obstetrical-perinatological parameters.

Cesarean Section↗
PubMed1985

Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester.

Treatment of 3T3-L1 cells with 0.1-1.0 nM insulin results in rapid (5-15 min) activation of a soluble protein kinase that phosphorylates serine residues in ribosomal protein S6. The insulin-stimulated kinase activity is detectable in confluent, nongrowing preadipocytes and adipocytes. In the presence of 2 micrograms of cycloheximide per ml, preconfluent 3T3-L1 cells also respond to insulin by acquiring an S6 kinase activity whose properties are the same as those of the enzyme activity elicited by insulin alone in growth-inhibited cells. The principal insulin-stimulated S6 kinase has a Mr of approximately equal to 50,000-60,000; there is a variable amount of activity that sediments with a Mr of about 80,000. The soluble enzyme exhibits optimal activity between pH 8 and pH 9, requires Mg2+ (10-20 mM), and is inhibited by Ca2+ (0.5 mM), Mn2+ (0.05 mM), and NaF (30 mM). GTP cannot substitute for ATP in the phosphotransferase reaction; cAMP, cGMP, phosphatidylserine plus diolein, the cAMP-dependent protein kinase inhibitor, and heparin (0.7 micrograms/ml) are without effect. Although treatment of 3T3-L1 cells with insulin does not influence the activity or the subcellular distribution of the phospholipid and Ca2+-dependent protein kinase C, exposure to the phorbol tumor promoter phorbol 12-myristate 13-acetate (PMA) results in translocation of protein kinase C to the membrane and activation of a soluble phospholipid and Ca2+-independent S6 protein kinase that has the same magnitude of activity and sedimentation behavior as the insulin-induced activity. Trypsin treatment of either 3T3-L1 cytosolic extracts or partially purified 3T3-L1 protein kinase C generates a small amount of S6 kinase activity of Mr 50,000. This activity, resolved by sucrose gradient centrifugation, is less active than that elicited by either insulin or PMA and, unlike the activities generated by insulin and PMA, is associated with histone kinase activity. The data suggest that the S6 kinase elicited by either insulin or PMA is neither protein kinase C, its phospholipid, and Ca2+-independent proteolytic derivative nor the result of proteolytic activation of an inactive proenzyme that can be reproduced by trypsin treatment of cell extracts in vitro.

Adipose Tissue↗
PubMed1985

The value of angiotensin-I-converting enzyme determinations in malignant and other diseases.

Mean values for serum angiotensin-I-converting enzyme (SACE), determined spectrophotometrically in 648 subjects, using the synthetic substrate hippuryl-L-histidyl-L-leucine, and expressed in units per milliliter, were: controls, 11.11 +/- 3.97 (n = 89); lung cancer, 6.50 +/- 3.26 (n = 87); tuberculosis of the lung, 8.93 +/- 4.60 (n = 68); pulmonary sarcoidosis, 21.18 +/- 14.93 (n = 48); pneumonia, 9.81 +/- 6.83 (n = 52); fibrosis, 11.18 +/- 8.26 (n = 34); diabetes mellitus, 10.90 +/- 7.51 (n = 29); ischemic heart disease, 8.98 +/- 6.19 (n = 42); pulmonary embolism, 13.20 +/- 3.91 (n = 5); and lymphomas, 11.66 +/- 5.44 (n = 36). The lowest values for SACE (5.92 +/- 1.95) were observed in 7 patients with pulmonary metastases. No relationship could be found between SACE and other laboratory parameters, nor between the enzyme activity in men and women. Evidence suggests that low SACE activity is often associated with extrapulmonary cancers of various organs. Levels were significantly decreased in cancer of the lung and pulmonary metastases and significantly (p less than 0.001) increased in sarcoidosis compared with other diseases, suggesting that SACE activity may be of value in the diagnosis and prognosis of cancer of the lung.

Adult↗
PubMed1985

Contribution to the pathogenesis of essential hypertension: a multivariate analysis of associated factors.

This study attempts to develop a general aetiological concept of essential hypertension by multidimensional investigation of its various risk factors in childhood and adolescence. The investigation is based on married couples and their children (609 parents and their 639 children, a total of 1248 persons), all of them chosen under special aspects. Familial and environmental characteristics of children and young people with hypertension are compared with those of normotensive volunteers of the same age. The multi-dimensionally interacting factors found to be associated with hypertension in children are: hypertension, diabetes and early infarction in relatives of the first or second degree as well as overweight at birth, obesity, nutritional patterns in the earliest and later stages of life, social environment and physical activity of the children and adolescents. The familial factors most likely lead to a predisposition to hypertension while environmental factors may subsequently contribute to its manifestation.

Adolescent↗
PubMed1984

[Changes in serum carboxypeptidase N in patients with lung sarcoidosis].

Serum carboxypeptidases N (E.C.3.4.17.3) were determined spectrophotometrically in 39 patients with untreated pulmonary sarcoidosis (radiographic stages I-II). Carboxypeptidases N were, due to variable substrate affinity, subdivided into N1 (CN1) and N2 (CN2). The control group consisted of 52 healthy persons. In addition, haemodynamics, chemical pathology, and lung function tests were evaluated. Among controls both CN1 and CN2 were slightly increased in females when compared to males. Patients with pulmonary sarcoidosis had significantly higher CN1 and CN2 activities (P less than 0.005) than the control group. Neither among healthy probands nor among patients with sarcoidosis were there positive correlations between haemodynamics, chemical pathology and lung function data on the one hand and CN1 and CN2 on the other. However, a linear correlation between CN1 and CN2 could be established in both groups (P less than 0.001).

Adult↗
PubMed1984

Controlled comparison of the pharmacodynamic effects of nicorandil (SG-75) and isosorbide dinitrate in man.

Nicorandil (SG-75) is a long acting mononitrate. A randomized, double-blind, crossover study in 10 healthy subjects has compared the haemodynamic actions of single sublingual doses of nicorandil 15, 30 and 60 mg with Isosorbide dinitrate (ISDN) 5 mg and placebo. Heart rate, blood pressure, systolic time intervals (STI) and left ventricular echocardiograms were used to assess haemodynamics over a 6 h period. Within 15 min of nicorandil administration, heart rate increased and peripheral resistance decreased (dose-dependent); the preejection period (corrected; PEPc) and the ratio of PEP to left ventricular ejection time (LVET) - PEP/LVET - were shortened by the 60 mg dose; the heart rate corrected electromechanical systole (QS2c) was almost unchanged; left ventricular end diastolic and systolic diameters (EDD and ESD) were diminished. The effects on certain parameters had not completely disappeared after 6 h. ISDN produced a similar pattern with somewhat less intense effects; although PEPc and PEP/LVET were prolonged. The effects of both drugs can be attributed to vasodilatation on both the arteriolar and venous sides. The predominant action of ISDN was to reduce preload and thereby to lengthen PEPc and PEP/LVET; in addition, it lessened afterload. Although nicorandil caused a distinct reduction in preload, as shown by the smaller EDD, the effects of afterload reduction were predominant at the high dose induced shortening of PEPc and PEP/LVET. The profile of action of nicorandil should encourage clinical testing to evaluate its ability to induce ventricular unloading.

Adult↗
PubMed1984

[Quality control from the viewpoint of clinical obstetrics].

Recommendation of the Society for Perinatal Medicine of the GDR for quality control in clinical obstetrics and early neonatology. A continuous data collection and periodical summary of the recommended most important figures are the supposition for internal and external comparison and the prediction of average efficiency for hospitals with different specialisation in obstetrics and early neonatology.

Female↗