Biomedical subjects
J Heinrich
Publications and source records attributed to J Heinrich.
[Treatment of primary dysmenorrhea with Jenapharm piroxicam].
36 patients with 432 menstrual cycles and primary dysmenorrhea were treated with Piroxicam-Jenapharm. Piroxicam-Jenapharm was given in a dose of 40 mg once daily for the first 2 days followed by 20 mg once daily. Piroxicam, a nonsteroidal-anti-inflammatory drug (NSAID) is an effective drug in reducing menstrual pain intensity in 80%. Piroxicam was well tolerated with no patient reporting side-effects. The treatment of primary dysmenorrhea with total 100 mg Piroxicam-Jenapharm over 3 days is recommended.
[Should there be quality control in obstetrics or not?].
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[Prevalence of root caries in a healthy adult population].
An epidemiological study involving 963 subjects aged 25 to 64 years revealed at least one carious and/or filled root surface in 40.2% of all females and in 42.7% of all males. The number of teeth and tooth surfaces affected by root caries increases continuously with age. In relation to the total number of teeth, males display a higher prevalence of root caries than females, with the exception of men aged between 55 and 64. High-risk susceptibility shows no correlation with age, although there are more surfaces at risk in males. Independent of the sex, root caries prevalence is highest in the molars and premolars of the mandible and in the canine of the maxilla; lower incisors are the teeth with the least caries involvement. Labial root surfaces are most frequently affected by caries in the mandible; the prevalence rate is twice as high in males than females. The lingual surfaces of maxillary molars of females and the proximal and buccal surfaces of incisors of males are the most frequently affected tooth surfaces.
[Proteolytic activities in bronchoalveolar lavage fluid in pneumonia and chronic bronchitis].
In 63 patients with chronic bronchitis, 61 patients with acute bacterial pneumonia, and in 11 control subjects, broncho-alveolar lavage fluid was investigated for its protease content. In smokers, we found the usual pronounced protease burden. As was expected, the two pathological groups also differed markedly on other points. In pneumonia, not only free elastase activity (from granulocytes (PMN] was markedly elevated, but also cathepsin-B-like activity (from alveolar macrophages (AM] was greatly increased, which would point up the important role of AM in this form of inflammatory. In this case of chronic bronchitis, function-analytically determinable obstruction parameters were associated with an increase in the elastase-like enzyme (from PMN), so that chronic obstructive bronchitis probably represents a special form of inflammation.
[Neonatal percentile values for the GDR--1985. Correlation of body weight and length in newborn infants (calculation of birth weight/body length in cm. with reference to gestational age)].
Taking account of the gestational age (28th to 42nd completed week of pregnancy) the sex-related ratio of birth weight to length (g/cm) for newborn infants is reported. This shows that observation of the correlation between birth weight and length with reference to gestational age makes a more accurate classification of newborn infants possible, rather than using a two dimensional classification (birth weight week of gestation).
[Effects of fentanyl peridural analgesia in labor on fetal heart rate, uterine contraction and postnatal adaptation].
The opioid Fentanyl was used in a dosage of 0.15 mg via a peridural catheter for birth analgesia (PDA) in a high risk collective of 40 female patients. A prolonged analgesia with good acceptance could be achieved with low dosage. The advantages of the mobilisation could be fully used because of telemetric monitoring and missing influence of the sympathetic nerve and undisturbed motoric activity. If a caesarean section was necessary we continued the peridural analgesia using 0.5 percent Marcain. Postnatal assessment of the condition of the newborn was not disturbed. Short-term irregularities in CTG--a decrease of the rate of acceleration, a silent oscillation pattern--are interpreted in the sense of a sleeping pattern, without harmful influence on the fetus. At present PDA is the most effective method in birth analgesia. It represents a valuable contribution to the care in the field of psychomotoric preparation of patients to birth. Considering the contraindications PDA with Fentanyl can be recommended in obstetrics.
The c1 repressor of bacteriophage P1 operator-repressor interaction of wild-type and mutant repressor proteins.
The c1 repressor gene of bacteriophage P1 and the temperature-sensitive mutants P1c1.100 and P1c1.162 was cloned into an expression vector and the repressor proteins were overproduced. A rapid purification procedure was required for the isolation of the thermolabile repressor proteins. Identification of the highly purified protein of an apparent molecular weight of 33,000 as the product of the c1 gene was verified by (i) the coincidence of partial amino acid sequences determined experimentally to that deduced from the c1 DNA sequence, and (ii) the temperature-sensitive binding to the operator DNA of the thermolabile repressor proteins. Analysis of the products of c1-c1.100 recombinant DNAs relates the thermolability to an unknown alteration in the C-terminal half of the c1.100 repressor. Binding to the operator DNA of c1 repressor is sensitive to N-ethylmaleimide. Since the only three cysteine residues are located in the C-terminal half of the repressor it is suggested that this part of the molecule is important for the binding to the operator DNA. This assumption is supported by the findings that a 14-kDa C-terminal repressor fragment obtained by cyanogen bromide cleavage retains DNA binding properties.
[Dose-reduced antihypertensive agents--use in complex nonmedicamentous therapy of hypertension].
In order to estimate the influence of a non-medicamentous therapy (CNT) on the consumption of medicaments and coronary risk in high blood pressure 73 hypertensives of a medicamentously stabilized CNT-group were examined in comparison to a group of the same size of patients with hypertension who were managed exclusively medicamentously for behaviour of blood pressure, need of antihypertensive drugs and changes of hypertension-associated risk factors. After an exactly controlled 6-month treatment hypertensives with additionally recommended far-reaching CNT showed an economization of medicaments by scarcely the half in comparison to the reference group. By means of suitable control methods a causal non-medicamentously conditioned decrease of blood pressure could be excluded. A different need of antihypertensive drugs was simulated by the exacter intake of medicaments in the index-patients. Notwithstanding the metabolic effects of the additional therapy have induced a positive change of atherogenic lipids. The examinations indicate in general the difficulty of the judgement of efficacy of non-medicamentous therapeutic measures in connection with a rational dose-reduced long-term therapy with antihypertensive drugs.
[How does the rate of participation in epidemiologic research affect oral health data?].
The question to which extent an unintended selection is linked with incorrect estimations of oral disease indicators by the readiness of subjects to participate is looked into within the framework of an epidemiological study. 896 primarily cooperative subjects and 70 originally noncooperative subjects aged from 25 to 64 years were examined. According to statistics, non-cooperative subjects were found to have more caries-infected teeth and less teeth filled. Generally, a smaller degree of dental care could be detected in these subjects, which should cause a critical discussion of the hitherto published parameters of oral diseases.
[Is there a connection between coronal and root caries involvement?].
The relationship between coronal and root caries was analyzed in a sample of 963 people aged 25 to 64 years. Subjects with root caries had fewer teeth, more teeth with untreated coronal caries, and more teeth which need conservative treatments and extractions than did people with no root caries. In the age older than 55 years those with root caries had more teeth in the average of 2.5 teeth for both sexes. The other parameters of dental health showed the same differences compared with younger subjects.
[Premature rupture of the fetal membranes--do neonatal maturity and risk of infection require an alternative decision or a compromise].
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[Prevalence of root caries in women].
An epidemiological study involving 764 women aged from 25 to 64 years revealed at least one carious and/or filled root surface in 40% of all subjects. The number of teeth and tooth surfaces affected by root caries continuously increased with age. Prevalence has tripled after the age of 45. By contrast, the risk of caries shows no dependence on age. The highest root caries prevalence is found in the molars of the mandible and in the canines of the maxilla; the lowest attacked tooth type is in the lower incisors. Root caries is most frequently found on all buccal surfaces of molars in the mandible and on the oral surfaces of molars in the maxilla.
[In memory of Johann Theodor Eller--26 November 1689 to 13 September 1760].
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Nursing resources and the delivery of patient care: the National Center for Nursing Research Perspective.
The nursing shortage has preoccupied nurse executives with daily crises about how to provide adequate staff resources to assure quality care and how best to plan for the future. This major societal concern affects all settings--but most particularly hospitals. The National Center for Nursing Research (NCNR) has been actively assessing this situation and has begun several targeted initiatives. Nurse executives have a vital role in this evolving research priority area focused on nursing resources and its effect on quality of care.
[Multicenter study of obstetrico-perinatologic quality control in the Rostock district. I. Comparative medical statistics].
Report about outcome-quality assessment in obstetrics and perinatology using an uniform check list for data collection in the district of Rostock. Various possibilities of outprint of the results in 1985 are demonstrated. For daily data collection in obstetrics a special book has been developed. The investigation concerns a data pool of more than 55,000 deliveries. Considering a trend of the results the following optimal criteria in obstetrics and perinatology are postulated: (table; see text) The check list of the Society of Perinatal Medicine of the GDR for obstetrical and neonatal data collection should be generally used. The soft ware for the computed data analyses has been developed by the "Rechenzentrum der Ernst-Moritz-Arndt-Universität Greifswald". Analysis and output of obstetrical and perinatological datas by means of a personal computer are prepared.
[Multicenter study of obstetrico-perinatologic quality control in the Rostock district. II. Analysis of results with graphic aids].
Various graphic diagrams of obstetrical and perinatological quality assessment between 1984-1986 in the district of Rostock are demonstrated. The advantages of centralization of premature labors are visible. The prenatal diagnosis of intrauterine growth retardation is still insufficient. With an upper cesarean section rate of 10% good perinatological results are achieved. The cesarean section rate of obstetrical departments without high risk concentration is below 5%. There is a highly subjective influence in vaginal operative decision. A mean rate of prematurity may be combined with a high rate of perinatal mortality caused by an unproportional part of very low birth weight infants. The small number of data of the obstetrical basic-check-list allows different possibilities of comparing quality assessment. Different levels of the results and the reasons are better visible by means of graphs. The preliminary results of outcome control justify a general introduction. By means of further data processing we will get better mathematical and graphical interpretations.
[Cardiotocography practice. CTG practice 17. Technical development].
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