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J Gottschalk

Publications and source records attributed to J Gottschalk.

At least 73 records · Page 4Linked to original sources
PubMed1986

[New aspects of the pathogenesis of acromegaly-somatoliberinomas].

According to modern knowledge, acromegaly can develop in at least three ways. A pituitary adenoma with growth hormone overproduction is the most frequent. Much rarer is ectopic growth hormone secretion by extra-hypophyseal tumors. A further possibility is the production of growth hormone releasing factor (GRF) by hypothalamic or ectopic tumors. This involves the secretion of a substance which selectively stimulates the GH producing cells of the pituitary. Special features of the clinical and morphological picture of this condition are described, based on the authors own observations. Two patients developed acromegaly: one had a retroperitoneal paraganglioma and the other a bronchial carcinoid. Ectopic GRF secretion could be confirmed radioimmunologically and immunohistologically in both cases. As a result of the on-going, tumor related GRF stimulation the patients developed nodular or diffuse GH-cell hyperplasia in the adenohypophysis. Since ectopic GH secretion does not cause hyperplasia of the adenohypophyseal cells, morphologic examination of the hypophysis can contribute to the differential diagnosis in such cases.

Acromegaly↗
PubMed1986

[Cell proliferation and glial fibrillary acidic protein in brain tumors].

The results of histoautoradiographic and immunohistochemical studies of biopsy specimens of 15 brain tumours are reported. The specimens were labeled with 3H-thymidine using an in vitro technique. Meningiomas, oligodendrogliomas and well differentiated astrocytomas showed a median S-phase fraction of about 1%. In contrast, the labeling indices of 4 from 7 anaplastic astrocytomas were higher (2.1, 3.0, 3.5, 11.4). With increasing degree of malignancy the proliferative heterogeneity of the tumours increases. In every glioma varying amounts of glial fibrillary acidic protein (GFAP) were detected immunohistochemically (PAP technique). In 3 high-grade gliomas (2 glioblastomas, 1 anaplastic astrocytoma) an inverse relation of the investigated parameters (high S-phase fraction, low GFAP expression) was found. An exact prediction on biological behaviour of an individual tumour by GFAP detection immunohistochemically is not possible, because a high GFAP content can be detected also in some malignant tumours. However, the 3H-thymidine labeling indices of viable parts of the tumours, probably reflecting the growth fraction seem to be clinically important parameters, especially in respect to the prognosis.

Adolescent↗
PubMed1986

[Importance of immunohistochemistry for neuro-oncology. III. Demonstration of glial fibrillary acidic proteins (GFAP) in anaplastic astrocytomas and glioblastomas].

Expression of gliofibrillary acidic protein in 23 anaplastic astrocytomas and 33 glioblastomas has been investigated and correlated with tumor behavior as reflected in both the length of the preoperative history and in the post-operative survival time. Three degrees of positive immunoreactivity to anti-GFAP can be distinguished: positive GFAP reaction in more than 2/3 of cells; in 1/3 to 2/3 of all cells; in less than 1/3 of all cells; negative reaction. All anaplastic astrocytomas and 27 of 33 glioblastomas showed GFAP positive reactions. The proportion of highly reactive tumors is higher by anaplastic astrocytomas than by glioblastomas (7 of 33). For both astrocytomas and glioblastomas there is a tendency for a decrease in the expression of GFAP to be associated with a shorter preoperative history and with a shorter survival time. This is more prominent for astrocytomas than for glioblastomas. This finding supports the opinion expressed in previous publications that the GFAP expression is reversely related to the level of tumor anaplasticity.

Astrocytoma↗
PubMed1985

[Unusual abdominal apudomas. I. Cushing syndrome in association with Zollinger-Ellison syndrome in an endocrine pancreas tumor].

Ectopic production of ACTH is observed in 6% of patients with Cushing syndrome. Ten percent of these cases are related to endocrine pancreatic tumors. In a few cases a multiplicity of hormones are produced. The combination with a Zollinger-Ellison syndrome is very infrequent. In the present case, a female patient aged 54, there was an interval between the onset of Zollinger-Ellison and Cushing syndrome. The combination of bilaterally enlarged adrenals in the absence of an adrenal adenoma and the presence of Crooke-cells in the adenohypophysis in a patient with Cushing syndrome are of diagnostic significance. This trias should always alert the physician to the possibility of extrahypophyseal ACTH production.

Adrenocorticotropic Hormone↗
PubMed1985

[Immunohistological determination of beta-endorphin in chromophobe, clinically hormone-nonproducing hypophyseal adenomas].

Pituitary adenomas are usually classified according to the nature of their proper hormonal production. Silent adenomas of the pituitary are tumors without clinical and biochemical evidence of overproduction of any known adenohypophyseal hormones. The proportion of such seemingly nonfunctioning tumors is 20 to 30%. Silent corticotropic adenomas are able to synthesize some normal or abnormal sequences of proopiomelanocortin precursor without any signs of hypercorticism. These tumors were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) positivity and chromophobic adenomas with moderate or no PAS positivity. All of our cases were chromophobic adenomas. Two of the cases were positive for beta-endorphin by immunofluorescence. ACTH immunoreactivity was not present in the cells. Electron microscopic study of the adenoma cells showed small secretory granules with a halo. The diameter of these granules varied from 50 to 250 nm. Automated morphometric and densitometric investigations of silent corticotropic adenomas and adenomas from patients with Cushing's disease gave different karyometric results. The most important practical problem arising from the present investigation was the high frequency of recurrence of silent corticotropic tumors.

Adenoma, Chromophobe↗
PubMed1985

[Significance of immunohistochemistry in neuro-oncology. I. Demonstration of glial fibrillary acid protein (GFAP) in extracranial metastases from primary brain tumors].

8 cases were studied to determine whether immunohistochemical investigation with anti-GFAP could contribute to confirming a primary brain tumor origin for an extracranial metastasis. The materials studied consisted of 3 glioblastomas, 3 anaplastic astrocytomas, and 2 medulloblastomas, along with their extracranial metastases. GFAP could be immunohistochemically demonstrated in all 6 primary glial tumors as well as in the metastases of the 3 astrocytomas and of 2 glioblastomas. The medulloblastomas and their metastases were immunohistochemically GFAP-negative. GFAP is thus a marker for extracranial metastases of astrocytomas and glioblastomas. A negative result however does not exclude the possibility that a metastasis is of glial origin as shown by the GFAP-negative metastasis of the one glioblastoma.

Adult↗
PubMed1984

Seeds for peace.

Explore the source record for details and available documents.

Civil Disorders↗
PubMed1984

[Multidimensional analysis of automatically measured karyometric data on pituitary adenomas].

131 pituitary adenomas (50 growth hormone-secreting adenomas, 19 prolactinomas, 7 adenomas associated with Cushing's disease and 55 endocrine-inactive adenomas) have been investigated morphometrically and densitometrically by use of a system for automated microscope picture analysis (AMBA). To classify the adenomas as good as possible we used a hierarchically structured classifier which uses the measured parameters. The adenomas associated with Cushing's disease differed mostly from the inactive tumors in their karyometric features. We found similar differences for growth hormone-secreting adenomas, whereas prolactinomas showed only small differences. Partly clear differences by multidimensional analysis appeared between adenomas associated with Cushing's disease, somatotropic adenomas and prolactinomas. Most of the clinically inactive tumours (37/55) showed similarities with the active adenomas. Only in 18 inactive tumors we could not find feature combinations corresponding with those of endocrine-active adenomas.

Acromegaly↗
PubMed1984

[Correlation between the morphological and functional parameters in hypophyseal adenomas of acromegalic patients].

A series of 50 human pituitary adenomas with acromegaly has been investigated morphologically and densitometrically by use of a system for automated microscope picture analysis (AMBA). Twenty nuclear and tissue features have been measured. The tumors were divided into eosinophilic, eosinophilic/chromophobe and chromophobe adenomas. We found no correlation between the analysed karyometric features and the blood hormone levels. But considering the results of the hematoxylin-eosin-staining, significant differences exist between the three histological subtypes. Eosinophilic adenomas show higher blood hormone levels than mixed and chromophobe tumors. Significant differences between the subtypes in some nuclear and tissue features allow a classification. Eosinophilic adenomas have bigger nuclei with higher extinction (that means higher DNA-content). The parameter EXTK (expected extinction at the borderline of the nuclei) was of great importance for the separation of mixed and chromophobe adenomas. The size of the adenomas had no influence on the blood hormone levels. Further studies are necessary to answer the question whether these results are a true expression of a different functional state.

Acromegaly↗
PubMed1983

[Automated morphometric and densitometric studies of pituitary adenomas].

A set of 131 pituitary adenomas has been investigated morphometrically and densitometrically by use of a system for automatical microscope picture analysis (AMPA). About 500 nuclei per adenoma have been scanned for estimating 20 nuclear and tissue parameters (5 and 10 min per adenoma). Endocrine inactive adenomas differ significantly by some parameters from active adenomas. The cell nuclei of inactive tumors are smaller, of more spherical and have higher extinction values on an average. The nuclei of adenomas from patients with Cushing's syndrome differ from the nuclei of prolactinomas and acromegalics because of their lower similarity to spheres. We found no correlation between the nuclear and tissue parameters analyzed in this study and the blood hormone levels.

Acromegaly↗
PubMed1980

[Tissue-dependent metabolic behaviour of collagen--autoradiographic and immunhistochemical findings (author's transl)].

After the intraperitoneal application of 3H-proline a higher grain density over the myocardium and the aorta in comparison with the cartilage, the glomeruli and the cutaneous connective tissue of rats was found. The maximal incorporation was established in the aorta at 6 h, in the skeletal muscle at 18 h after the injection of radioactive proline. Immunhistochemical findings reported in the literature and first results of our own indicate a special distribution pattern of the various collagen types in the organs under study. Seen in this connection the autoradiographic results may imply that type I and III collagen has a higher metabolic intensity than type II and IV collagen. Animals with renal hypertension of 3 weeks duration show an increase in the ratio of the extranuclear to the intranuclear grain density in the myocardium and the aorta after 3H-proline application.

Animals↗
PubMed1977

Team nursing coverage of prenatal-intrapartum patients at a university hospital. An innovation in obstetric nursing.

A unique approach in utilization of nursing personnel was instituted at the University of Colorado Medical Center to alleviate the following patient care problems: 1) lack of continuity of care of obstetric patients, 2) inadequate prenatal instruction, and 3) the unpredictability of patient census in the labor and delivery area. Half the nurses from the labor and delivery area were organized into four teams of two nurses each who acquired a case load of patients for antepartum care. When a patient was admitted to the hostpial in labor, the nurse from her team who was on call came in and provided all nursing care during the intrapartum period. The problems and benefits of this new approach to nursing care are discussed.

Colorado↗
PubMedDate not supplied

Third World women call for a balanced perspective on women's health.

In 1990 a conference entitled "In Search of Balanced Perspectives and Global Solidarity for Women's Health and Reproductive Rights" took place in Manila, the Philippines. The message from the Third World women who attended was that their struggles for personal and reproductive freedom are integrally linked with their dependent economic status. In addition, the conference addressed the violence many Third World women suffer as a result of oppressive state and religious policies. More than 50% of the women who attended one panel testified that they had personally experienced "state violence." The women called for an immediate end to women's oppression via nationalism and militarism in addition to racism, sexism, and classism. They represented a challenge to all of us--to work toward a balanced perspective on women's health in the context of the socioeconomic and political development of all peoples.

Developing Countries↗