Biomedical subjects

J Gottschalk

Publications and source records attributed to J Gottschalk.

75 records · Page 5Linked to original sources

PubMedDate not supplied

HEA 125 and Ber EP4: two monoclonal anti-epithelial, non-cytokeratin antibodies distinguishing metastatic carcinomas from glial tumors.

Since some monoclonal anti-cytokeratin antibodies also react with glial tumors to a relatively high degree, an immunohistochemical study was performed to examine the reaction of 40 glial tumors and neuroepithelial tumors with glial differentiation to the monoclonal anti-epithelial non-cytokeratin antibodies HEA 125 and Ber EP4. Seven of these tumors were cytokeratin-positive neoplasms (6 gliosarcomas and 1 ependymoma). In addition, 20 metastatic carcinomas were investigated. All glial tumors showed a negative reaction to HEA 125 and Ber EP4, whereas 19 of the 20 metastatic carcinomas were positive with these two monoclonal antibodies. HEA 125 and Ber EP4 thus can be used as additional markers especially in cytokeratin-negative small cell carcinomas.

Antibodies, Monoclonal↗

PubMedDate not supplied

[Age dependent changes in signal transduction of glucocorticoid hormones after physiological stress in liver cells of male Wistar rats].

After physiological stress older male Wistar rats showed a faster normalization of the corticosterone level in serum and of the concentration of unoccupied glucocorticoid receptors in liver cytosol than young ones, which is contrary to female rats. The nuclei binding of glucocorticoid receptor complexes (GRC) was significantly reduced in older control animals compared with young ones. The nuclei binding of GRC was reduced in young rats until 60 min after stress compared to controls, whereas it had been increasing in older animals at this time. Contrary to female rats, the addition of the endogenous ATP-stimulated translocation promoter (ASTP) alone or together with ATP did not elevate the nuclei binding, but it groups. Crossing experiments using nuclei of controls and GRC of control and stressed animals, resp., seem to disclose a longer association of GRC with the nuclei in old animals than in young ones.

Aging↗

PubMedDate not supplied

Dysembryoplastic neuroepithelial micro-tumor in a 75-year-old patient with long-standing epilepsy.

Dysembryoplastic neuroepithelial tumors (DNT) are rare, cortically located neoplasma associated with intractable partial complex seizures. This entity was first described by Daumas-Duport et al. [1988], who also coined the term DNT. In that report, at the time of operation, the patients' ages ranged from 3 to 30 years and the duration of symptoms ranged from 2 to 18 years. In contrast, we observed a histologically comparable tumor in a 75-year-old female with a 60 year epilepsy history. Autopsy revealed an 8 mm large tumor in the right hippocampus. In view of the extremely prolonged course of the patient's symptoms and the complete lack of excessive cell proliferation, the differentiation of a genuine tumor versus a hamartoma remains equivocal.

Aged↗