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Biomedical subjects

J Golding

Publications and source records attributed to J Golding.

At least 199 records · Page 11Linked to original sources
PubMed1985

Febrile convulsions in a national cohort followed up from birth. I--Prevalence and recurrence in the first five years of life.

Of 13 135 children followed up from birth to the age of 5 years, 303 (2.3%) had febrile convulsions. Prior neurological abnormality had been noted in 13. Of the 290 remaining children, 57 (20%) presented with a complex convulsion, and 103 children (35%) went on to have further febrile convulsions. The risk of further febrile convulsions varied with the age at first convulsion and the presence of a history of convulsive disorders in relatives. There were no significant differences between the sexes.

Age Factors↗
PubMed1985

Febrile convulsions in a national cohort followed up from birth. II--Medical history and intellectual ability at 5 years of age.

Three hundred and three children with febrile convulsions were identified in a national birth cohort of 13 135 children followed up from birth to the age of 5 years. Breech delivery (p less than 0.05) was the only significantly associated prenatal or perinatal factor. There were no associations with socioeconomic factors. Excluding the 13 known to be neurologically abnormal before their first febrile convulsion, children who had had a febrile convulsion did not differ at age 5 from their peers who had not had febrile convulsions in their behaviour, height, head circumference, or performance in simple intellectual tests.

Analysis of Variance↗
PubMed1985

What else do SIDS risk prediction scores predict?

Various aspects of the medical and social history of 12 743 children examined at the age of 5 years were related to two risk scores for the sudden infant death syndrome (SIDS) computed from data collected in the neonatal period. Children at high risk of SIDS were also at high risk of pneumonia, non-accidental injury and repeated or prolonged hospital admissions. There were stronger associations, however, with factors indicating social disruption and environmental disadvantage.

Accidents↗
PubMed1985

Non-natural deaths in two health districts.

Details of all deaths in children (less than 16 years) resident in Oxfordshire and West Berkshire from 1970-9 were ascertained; 259 non-natural deaths were identified. Half were due to road traffic accidents, and another quarter occurred during play outside the home. There were differences in sex, age, and social class between the types of accident. A clustering of fatal accidents, particularly to pedestrians, was observed at around the time of the child's birthday. It is suggested that the excitement engendered overrides the child's normal caution. Local action to reduce accidents from specific hazards might complement national education campaigns.

Accidents↗
PubMed1985

Identification of cases of sudden infant death syndrome from death certificates.

A method is proposed for identification of cases of sudden infant death syndrome (SIDS) from information available on death certificates. Deaths at ages between 7 days and 2 years, referred to a coroner, having certain specified causes of death codes, identified 160 of 169 cases of SIDS confirmed as such by a pathologist. The sensitivity of the method was 94% and the specificity was 97%.

Death Certificates↗
PubMed1984

Is there a link between cot death and child abuse?

Forty five babies delivered in Oxford obstetric units who subsequently died unexpectedly in infancy were compared with 134 controls matched for maternal age, social class, parity, and year of birth to see whether five factors identified in an earlier study as predictive of subsequent child abuse would also predict the sudden infant death syndrome. Epidemiological findings had suggested certain similarities between the two events. In contrast with babies who were abused, four of the five factors did not distinguish between babies who died suddenly and unexpectedly and their controls, but there was a slight increase in the proportion of mothers of babies who died suddenly and unexpectedly for whom nursing staff thought that support and advice on feeding the baby were needed. Factors predictive of child abuse did not predict sudden infant death in this study.

Affective Symptoms↗
PubMed1984

Factors associated with delayed onset of regular respiration.

In a population of 16333 singleton births born in one week of April, 1970, 4.4% failed to establish regular respiration within 3 min of birth. A follow-up at 5 years of age collected medical, educational and sociological information on 79.6% of the survivors of the cohort identified by the birth survey. Data have been analysed to investigate the relationships between the delay in the onset of regular respiration and possible risk factors identifiable prior to or at the time of birth. Complex statistical analysis employing linear modelling techniques showed that the delay in the onset of respiration was primarily related to: null and high parity; antepartum haemorrhage (especially placenta praevia); pre-eclampsia; breech delivery; Caesarian section and low birthweight. There was no association with maternal smoking during pregnancy or with social class. These conclusions are reasonably consistent with those drawn from other studies using alternative measures of asphyxia.

Child, Preschool↗
PubMed1984

Delayed onset of regular respiration and subsequent development.

A comprehensive survey carried out at birth, data on mortality and a 5 year follow-up covering medical, educational and sociological aspects of child development were available for singleton births born in one week of April 1970. The survey at 5 years of age included 12363 children, 79.6% of the surviving cohort. An assessment has been made of the extent to which delay in the onset of regular respiration at birth is associated with the subsequent development of the child. Using the results of our previous investigations, the relationships between this delay and other factors known at the time of birth have been taken into account. The distributions of a large number of development variables were not significantly different for groups of children determined by respiratory delay at birth, but there was an association with mortality and cerebral palsy. In addition, there was an unexpected relationship between delayed onset of respiration and subsequent bronchitis. This association remained significant after controlling for possible confounding effects using linear modelling techniques.

Bronchitis↗
PubMed1983

Plus ça change: predictors of birthweight in two national studies.

The 16 989 singleton births in one week of March, 1958, studied by the British Perinatal Mortality Survey, were subjected to an analysis of covariance, which showed that major factors associated with birthweight of the infant were: maternal height, history of smoking in pregnancy, parity and history of pre-eclampsia during the pregnancy. The same analysis was repeated on the data collected on 16792 singletons born 12 years later in one week of April, 1970 and studied by the British Births Survey. In spite of major changes in obstetric practice and in the maternal population, the same factors were shown to be highly significant and the magnitude of the associations had changed little.

Analysis of Variance↗
PubMed1983

Analysis of completed reproductive histories: a cautionary tale.

Recent authors have suggested that cross-sectional studies of adverse outcome of pregnancy are misleading, and that the only valid method of analysis controls for eventual number of pregnancies. The present study shows, by simple examples, that such a method produces results that cannot be interpreted in the way claimed for them.

Birth Order↗
PubMed1983

Breast feeding, eczema, asthma, and hayfever.

The association of breast feeding with rates of atopic illness during the first five years of life was assessed in a national study of 13 135 children studied during the first week and at age 5 years. Eczema was reported more often in children who had been breast fed; this relationship persisted even after allowance was made for social and family factors influencing the likelihood both of breast feeding and of eczema; the other factors most significantly associated with rates of eczema were parental history of eczema or asthma and advantaged family socioeconomic status. A similar, but less pronounced, positive association of breast feeding with reported hayfever became non-significant after adjustment for intervening factors. Rates of reported asthma were not influenced by breast feeding. "Any wheezing" including asthma was reported more often in children who had not been breast fed, but this association disappeared after adjustment for parental asthma and maternal smoking. Breast feeding does not appear to protect against these atopic diseases. The positive association with reported eczema might relate to accuracy of diagnosis or to associated influences not considered in the analysis; alternatively, it might be due to (recent) environmental contaminants crossing in breast milk, causing eczema in the child.

Asthma↗
PubMed1983

Maternal anti-nauseants and clefts of lip and palate.

1 Data on drug prescriptions were obtained from the general practitioners of 196 women who had had infants with clefts of lip or palate and those of 407 control women, matched for age, parity, social class and year of delivery. 2 There was no excess of index women who had presented with nausea or vomiting. 3 There was a significant excess (12 cases, nine controls, P less than 0.02) of women who had been prescribed Debendox (the 3-constituent, or pre-1976, formulation of Bendectin) in early pregnancy. 4 This result was not thought to be conclusive evidence of a teratogenic effect but caution in prescribing is advised pending more extensive studies.

Abnormalities, Drug-Induced↗