Search PubMed⌕ Search

Biomedical subjects

J Godlewski

Publications and source records attributed to J Godlewski.

At least 55 records · Page 3Linked to original sources

[Apotemnophilia].

Explore the source record for details and available documents.

Aged↗

[Typology of rape].

Explore the source record for details and available documents.

Emotions↗

Pharmacokinetic interaction of psychotropic drugs. I. Divergent effect of mianserin on pharmacokinetics and pharmacodynamics of amphetamine.

Pharmacokinetics of amphetamine and stereotypy caused by this drug was studied after premedication with two doses of mianserin (2 and 10 mg/kg). High doses of mianserin depressed the amphetamine level in blood and cerebral tissue and increased the stereotypy. The results suggest that the potentiation of the action of amphetamine by mianserin is mainly due to pharmacodynamic synergism and depends on the blockade of central serotonergic receptors by mianserin.

Amphetamine↗

On P-chlorphenylalanine interference with phenobarbital formation from primidone.

Premedication with PCPA antagonized in rats the anticonvulsant activity of Primidone and of other drugs against seizures evoked by electroshock. Only in the case of Primidone, however, the anticonvulsant activity could not be re-established by increasing the dosage. Our investigations have shown that PCPA caused a strong inhibition of the conversion of Primidone to phenobarbital, both in vivo and in vitro.

Animals↗

The effect of chlorpromazine on pharmacokinetics and pharmacodynamics of phenobarbital in X-irradiated rats.

Male Wistar rats were irradiated with a single 600R dose of X-rays on the whole body. Chlorpromazine was given 30 min before phenobarbital. Phenobarbital sleeping time was prolonged by chlorpromazine both in irradiated and non-irradiated rats. On the 3rd day after irradiation the prolongation of the phenobarbital sleep by chlorpromazine was more marked than on the 6th day. No correlation between the pharmacodynamic action of phenobarbital and its cerebral level was noted.

Animals↗