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Biomedical subjects

J Godlewski

Publications and source records attributed to J Godlewski.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Investigations on the interaction between cyproheptadine and amphetamine.

The effect of cyproheptadine (CPH) given in doses of 1.25 and 5 mg/kg intraperitoneally one hour before administration of D-(+)-amphetamine (AMPH) 5 mg/kg subcutaneously was studied. A moderate increase was observed in the intensity of amphetamine-induced stereotypy and a significant rise in the number of rearings after premedication with CPH 5 mg/kg. In pharmacokinetic investigations the serum level of AMPH was found to be decreased in the animals after CPH premedication. The biological half-time of AMPH in the blood was reduced after premedication with CPH 5 mg/kg. On the other hand, the level of amphetamine rose in the brain following premedication with CPH in both doses. These results suggest that the rise in brain AMPH level could be responsible for intensification of AMPH effects induced by CPH premedication.

Amphetamine↗
PubMedDate not supplied

Effect of thymoanaleptic agents on the course of experimental arterial hypertension and catecholamine content in tissues and urine.

Experimental hypertension was induced in rats by two methods. In the course of hypertension development the rats of experimental groups were treated with following tricyclic antidepressive agents: Imipramine, Opipramol, Amitriptylline and Nortriptylline injected in doses of 5.0 or 0.5 mg per 1 kg of body weight. Higher doses of the above drugs inhibited the development of hypertension, whereas the lower doses had no effect on arterial blood pressure.

Animals↗
PubMedDate not supplied

Role of serotoninergic and adrenergic mechanisms in the action of prominal.

The aim of this work was determination of the interrelations between the metabolism of biogenic amines in the brain and the action of Prominal. The power of the anticonvulsive action of Prominal was decreased by p-chlorphenylalanine (PCPA). The influence of the tested anticonvulsant on the levels of noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and on serotonin turnover was investigated and a correlation was found between the anticonvulsive action of Prominal and its effect on the serotonin level. Prominal increased serotonin synthesis and turnover in the brain. It may be supposed that the anticonvulsive action of Prominal is connected with its effect of serotonin metabolism in the central nervous system.

Animals↗