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Biomedical subjects

J G Moore

Publications and source records attributed to J G Moore.

At least 109 records · Page 6Linked to original sources
PubMed1981

Adenocarcinoma of the uterine cervix.

One hundred patients with primary adenocarcinoma of the uterine cervix were evaluated. Of the 48 Stage I patients, 13 were treated with radical surgery, 16 with radiation alone, and 19 with combination therapy. Life table analysis of Stage I patients showed no significant difference in survival for those treated with radical surgery or combination therapy. Both groups had a greater five-year survival (P less than 0.05) than those treated with radiation. Recurrences in Stage I were more frequent with primary radiation alone, both locally and at distant sites (P less than 0.01). Greater tumor size was related to poorer survival, and failures in patients with larger lesions were more common in those treated with radiation therapy. Survival for the 32 Stage II patients was greater for those treated with combination therapy. Higher tumor grade was associated with poorer survival for each stage, regardless of treatment. More complications were associated with radiation therapy than with radical surgery. Radiation therapy alone is not sufficient for patients with Stage I and II disease, and radical surgery may be appropriate treatment for Stage I disease.

Adenocarcinoma↗
PubMed1981

Gastric emptying of varying meal weight and composition in man. Evaluation by dual liquid- and solid-phase isotopic method.

Ten subjects were given self-selected filling meals (mean weight = 1692 g) and meals of 900 and 300 g. The three meals varied in composition and total kcal. Solid and liquid phase gastric emptying was evaluated using 99mTc-sulfur colloid-labeled chicken liver and [111In]DTPA, and emptying was quantitated using the geometric mean of the anterior and posterior counts. Emptying of the solid-phase marker was linear; mean half-emptying times were 277 min, 146 min, and 77 min for the filling, 900-g, and 300-g meals, respectively. Emptying of the liquid-phase marker was curvilinear, mean half-emptying times were 178 min, 81 min, and 40 min, for the filling, 900-g, and 300-g meals, respectively. Thus, meals of larger weight and kcal content were associated with longer emptying times for both solids and liquids.

Adult↗
PubMed1981

The effect of search time on perception.

A group of 100 carefully selected chest radiographs was read by ten observers, five experienced and five inexperienced. The radiographs were chosen to present the readers with a disproportionately large number of both subtle abnormalities and nonpulmonary lesions. Each reader was allowed to search the radiographs for as long as appropriate, up to a maximum of four minutes. The length of time taken for each observation was recorded to the nearest second. The time-perception data were plotted on both linear and semilogarithmic graphs. The results showed that experienced readers concluded their visual search while positive detection rate was higher than the rate for false-positives. For lesions in the central phasic, with both a rapid and a slow component of perception. If these data are plotted on a semilogarithmic scale, each of the two components plots as a straight line. For lesions in the periphery of the radiograph (chest wall and upper abdomen), the time-perception curve is monophasic, showing only a slow component.

False Negative Reactions↗
PubMed1981

Effect of wine on gastric emptying in humans.

The effect of wine on gastric emptying of meals was studied in 10 healthy male subjects. A dual radioisotopic method was employed utilizing isotope tracers added to the liquid (111In-diethyltriamine pentaacetic acid) and solid phases (99mT-tagged chicken liver) of the meal. In a random design subjects were fed two standardized 900-g meals containing 450 g of solid food ingredients and 450 g of either Cabernet Sauvignon (mean ethanol concentration = 9500 mg/dl) or low-alcohol Cabernet Sauvignon (mean ethanol concentration = 1312 mg/dl). In addition, 7 of the 10 subjects were fed wine and low-alcohol wine without solid food. Wine, when compared with low-alcohol wine, did not significantly alter gastric emptying of either liquid or solid food components.

Adult↗
PubMed1981

Consuming capacity for single meals in humans after a 24-hour fast.

Self-selected, ad libitum meals were repeatedly fed to 5 healthy male subjects in order to empirically assess the influence of various intravenous and intraduodenally delivered solutions on food consumption. The solutions included i.v. and i.d. saline, i.v. and i.d. glucose, and i.v. autologous plasma feedings which had been previously obtained from the subjects after feeding or fasting states. Each subject had 11 meals under the various conditions. Liquid and solid food intakes in grams and calories were measured with each meal. No significant mean differences in food consumption were detected between the various i.v. and i.d. conditions; hence, food consumption for all meals was combined for the 5 subjects. Significant individual differences in food intakes were found that could not be correlated with body size, gastric emptying rates, or with the capacity to secrete gastric acid.

Adult↗
PubMed1980

Influence of glucose on cephalic-vagal-stimulated gastric acid secretion in man.

Gastric acid secretion was stimulated by the preparation and anticipation of a self-selected meal in five healthy male subjects. The purpose of the investigation was to determine whether intravenous (IV) or intraduodenally (ID) administered glucose solution given during the test hour of meal preparation and anticipation altered psychically stimulated acid secretion. Each subject had seven self-selected meals and received in a randomized, blinded manner the following IV or ID solutions during the test hour: IV normal saline (200 ml/hr and 1000 ml/hr; N = 2); IV glucose, 10 g (200 ml/hr, 5% D/W; N = 1); IV glucose, 25 g (250 ml/hr, 10% D/W; N = 1); IV glucose, 100 g (1000 ml/hr 10% D/W: N = 1); ID normal saline (1000 ml/hr; N = 1) and ID glucose, 30-100 g (600-2000 ml/hr, 5% D/W; N = 1). Analysis of results revealed that only ID glucose significantly inhibited psychically stimulated acid secretion at doses and resultant plasma glucose concentrations considered physiological.

Adult↗
PubMed1980

Intraocular implants: the postoperative astigmatism.

A series of 100 cases of intraocular implants has been considered, especially with regard to the postoperative astigmatism. This was found to be far higher than in a similar series of cases subjected to the same techniques without an implant. The operative results appear to be as good as in any conventional series, except for 2 cases. The reason for the excessive astigmatism (average 2.84 D) is not clear but the following factors have been suggested: (1) faulty surgical technique, that is, irregular corneal healing; (2) astigmatic errors in the actual intraocular lens itself; (3) tilting of the intraocular lens; (4) the intraocular lens, owing to its own inherent weight, may pull on the iris and ciliary body and even distort the cornea on healing. A summation of all these factors could produce an undesirably high degree of astigmatism.

Astigmatism↗
PubMed1980

The relationship of gastric acid secretion to plasma glucose in five men.

Twelve-hour basal gastric acid collection (no. = 113) and insulin-stimulated acid studies (no. = 47) were obtained in five healthy male volunteers. Basal collections were obtained during infusion with intravenous saline, 5% glucose, or 15% glucose solutions. Various insulin dosages were used for the insulin studies. Thus, for each subject a hyperglycemic to hypoglycemic plasma glucose range was produced which could be related to acid output. In the normoglycemic range (110 to 57 mg/100 ml) a graded acid increase was noted in association with a graded reduction in plasma glucose. This suggests that physiological variations in plasma glucose influence acid secretion in man.

Adult↗
PubMed1980

Effects of meal size and correction technique on gastric emptying time: studies with two tracers and opposed detectors.

Geometric-mean correction of gastric radioactivity can be used to correct for the distribution, depth, and attenuation of the radionuclide. Anterior image counts were compared with the geometric mean of anterior and posterior counts, using a computer-assisted gamma camera. Phantom and human studies using Tc-99m and In-111 were used to evaluate the difference between anterior-only and geometric-mean data. The effect of meal size on gastric emptying was studied using Tc-99m and In-111 simultaneously as solid-phase and liquid-phase markers. Differences between the anterior data and AP-PA data corrected by geometic mean were compared in ten healthy male subjects. The average half-emptying times for solid food, with 1692-, 900-, and 300-g meals, were 277, 146, and 77 min, respectively. Average half-emptying times for liquid were 178, 81, and 38 min for the same meals.

Gastric Emptying↗
PubMed1979

Urinary tract endometriosis: enigmas in diagnosis and management.

The diagnosis and management of endometriosis presents several enigmas. This review, of eight patients with endometriosis involving the urinary tract, from three large clinical services in the City of Los Angeles, highlights some very difficult problems. Not only diagnostic errors but also inappropriate conservatism and inadequate surveillance have led to compromised function, resection, and/or destruction of the kidneys, ureters, or bladder. The series indicates those findings which are likely to result in urinary tract destruction and points out those clinical situations in which delays or conservative management must be undertaken only with pressing indications and then only with continued and careful surveillance.

Adult↗
PubMed1979

Gastric secretory and humoral responses to anticipated feeding in five men.

It is believed that humans anticipate appetizing meals by increasing vagally mediated gastric acid secretion. Studies were conducted on 5 normal male volunteers to characterize further the secretory response to anticipated meals. Plasma gastrin and glucose levels were monitored to assess the possibility that these humoral factors participated in the observed secretory changes. Subjects were not fed for 22 hr and were intubated at 10 AM. Basal gastric collections were begun, and at 1 PM on different days, subjects either (a) selected meals of choice prepared in their presence for 1 hr before nasogastric tube withdrawal and meal ingestion or (b) were not food-teased or fed. Gastric collections were obtained every 10 min during the "test" hour (1-2 PM) during both (a) and (b) studies and titrated for gastric acid. Blood samples for plasma glucose and RIA gastrin were obtained during basal and test hours every 10 min. Pentagastrin-stimulated maximal acid output studies were conducted on all subjects on separate days. Results showed a progressive and statistically significant rise in gastric acid secretion when an appetizing, self-selected meal was anticipated. The magnitude of this rise was 55% of the mean pentagastrin-induced acid response. This acid response did not correlate with changes in plasma glucose or gastrin. The study demonstrated that pure psychic stimulation may be as effective an acid stimulant as sham feeding.

Adult↗
PubMed1978

Influence of jejunoileal bypass on protein metabolism during pregnancy.

Management of the pregnant patient who has undergone operation for jejunoileal bypass poses many problems for the attending obstetrician. Several recent studies have broadened our knowledge of this group of patients. Unfortunately, the significance of this form of weight loss upon the developing fetus is at best only poorly understood. In our study, amino acid chromatography was performed at 34 weeks' gestation and at delivery in order to assess the impact of this procedure upon maternal and fetal (cord blood) amino acid concentrations. Results suggest that protein metabolism in the patient who has had intestinal bypass without resulting complications and in her fetus is comparable to that in normal pregnancy. Altered amino acid profiles were observed in one twin gestation and in one patient who continued to lose weight throughout pregnancy. The significance of these observations is discussed with respect to the relationship of protein deprivation to neonatal development.

Adult↗
PubMed1978

Treatment of recurrent Paget's disease of the vulva with topical bleomycin.

Seven patients with recurrent Paget's disease of the vulva underwent treatment with topical bleomycin (NSC 125066-Blenoxane, Bristol Laboratories) ointment. None had an associated invasive carcinoma. Four patients experienced a complete, objective response to this therapy, and one of these has responded completely to treatment of a subsequent recurrence. In two patients the response could not be evaluated. All patients experienced pain in the treated area; one, developed systemic toxicity to bleomycin requiring cessation of therapy. Topical bleomycin appears to benefit selected patients with recurrent Paget's disease of the vulva.

Administration, Topical↗