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Biomedical subjects

J G Lane

Publications and source records attributed to J G Lane.

At least 55 records · Page 3Linked to original sources

Dupuytren's contracture in an adolescent.

Dupuytren's disease is a fibrotic process that can impair hand function by producing flexion contractures of the digits. The hypertrophic changes and contracture of the palmar fascia are frequently encountered in the geriatric population but can also occur in the adolescent age group. There is a definite genetic predisposition, and familial occurrences are common. Females of any age and males under age 40 are more prone to postoperative complications than other patients.

Adolescent↗

Laryngeal chondritis in Texel sheep.

An obstructive, upper respiratory tract disease characterised by severe dyspnoea and deaths has been recognised in Texel sheep. It is caused by chronic suppuration within the arytenoid cartilages of the larynx resulting in swelling and occlusion of the lumen. The clinical and pathological features of the disease are described and its possible cause and treatment are discussed.

Animals↗

Cardiovascular abnormalities accompanying acute spinal cord injury in humans: incidence, time course and severity.

The frequency of cardiovascular abnormalities was evaluated in 71 consecutive patients with acute injury to the spinal cord. Persistent bradycardia was universal in all 31 patients with severe cervical cord injury and less common in milder cervical injury (6 of 17) or thoracolumbar injury (3 of 23) (p less than 0.00001). Marked sinus slowing (71 versus 12 versus 4%, respectively, p less than 0.00001), hypotension (68 versus 0 versus 0%, p less than 0.00001), supraventricular arrhythmias (19 versus 6 versus 0%, p = 0.05) and primary cardiac arrest (16 versus 0 versus 0%, p less than 0.05) were significantly more frequent in the severe cervical injury group. The frequency of bradyarrhythmias peaked on day 4 after injury and gradually declined thereafter. All observed abnormalities resolved spontaneously within 2 to 6 weeks. The primary mechanism underlying these observations appears to involve the acute autonomic imbalance created by the disruption of sympathetic pathways located in the cervical cord. Acute severe injury to the cervical spinal cord is regularly accompanied by arrhythmias and hemodynamic abnormalities not found with thoracolumbar cord trauma. These abnormalities are limited to the first 14 days after injury, a period in which life-threatening disturbances must be anticipated.

Adolescent↗

Observations on headshaking in the horse.

The clinical records of 100 cases of headshaking in horses were reviewed. Possible causes of the abnormal behaviour were identified in 11 animals; these included ear mite infestation, otitis interna, cranial nerve dysfunction, cervical injury, ocular disease, guttural pouch mycosis, dental periapical osteitis and suspected vasomotor rhinitis. However, in only two of these could it be shown that correction of the abnormality led to elimination of the headshaking. The additional clinical signs exhibited by the other idiopathic cases of headshaking included evidence of nasal irritation, sneezing and snorting, nasal discharge, coughing and excessive lacrimation. Many of these horses also showed a marked seasonal pattern with respect to the onset of the disease and the recurrence of signs in subsequent years. The clinical presentation of idiopathic headshakers and the seasonal incidence of the signs closely resemble allergic rhinitis in man.

Animals↗

Radiographic examination of the facial, nasal and paranasal sinus regions of the horse: I. Indications and procedures in 235 cases.

The radiographic procedures used for examination of the facial area and paranasal sinuses of 235 horses are reported. Clinical indications for these examinations and the diagnoses made are reviewed. Unilateral nasal discharge was the commonest reason for radiography, accounting for about one third of cases, most of which had radiological signs of paranasal sinus disease recognisable on erect lateral films. Oblique projections were required to obtain further information about the maxillary dental arcades and ventro-dorsal views demonstrated sinus expansion and extension of disease into the nasal cavity. In 24 horses with bilateral nasal discharge, the origin was usually shown to be in the lower respiratory tract and radiographic abnormalities were found in only 20 per cent of cases. Facial swelling was a feature of 25 per cent of cases; the commonest causes were premolar periapical disease, best shown on oblique views with the patient recumbent, and suture periostitis, easily demonstrated on erect lateral films. Other causes of facial swelling, which required multiple radiographic projections for evaluation, were sinus cysts and tumours and peripheral soft tissue masses. Epistaxis for which no cause could be found in the lower respiratory tract was the indication for radiography in a further 10 per cent of cases. In almost half of these a radiopaque shadow representing an ethmoid haematoma could be seen on an erect lateral film. A sinus cyst and a tumour were also recorded but most other causes of epistaxis failed to produce radiographic signs.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Radiographic examination of the facial, nasal and paranasal sinus regions of the horse. II. Radiological findings.

The radiographic findings in 167 horses subjected to radiography of the facial area, nasal cavity and paranasal sinuses are recorded. Cases were grouped according to clinical diagnosis and the common and disparate radiographic features between and within groups are discussed. Dental disease occurred most frequently and accounted for about 30 per cent of cases, most of which had periapical infection. This disorder presented as two distinct clinical entities in almost equal numbers affected teeth with roots rostral to the maxillary sinus usually produced facial swelling, whereas those with roots within the sinus were generally associated with nasal discharge as a result of secondary sinusitis. In the former group periapical changes could readily be identified on radiographs, but in the latter group affected teeth could be recognised with confidence in only about half the cases. Primary sinusitis was the commonest specific condition recorded and accounted for 32 cases, three of which were mycotic. Using lateral erect projections, comparison of the radiographic features of primary sinusitis and sinusitis secondary to dental disease showed some useful differentiating signs. In four ponies, rhinitis associated with sinusitis led to disruption of the intra-nasal structures but mycotic rhinitis, nasal ulceration and an intra-nasal foreign body produced no radiographic abnormalities. Sixteen cases of suture periostitis were recorded, with varying degrees of new bone formation, and of 13 animals presented for evaluation of trauma, pre-diagnosed fractures were demonstrated in 10 and complications due to sinusitis in three.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Equine paranasal sinus cysts: a report of 15 cases.

The clinical and radiographic features of 15 cases of paranasal sinus cysts are described. Breed, sex and side frequency were unremarkable but two distinct categories of age incidence emerged. Onset of signs had occurred before one year of age in three cases, while all but two of the remaining 12 animals were older than nine years. The most common clinical signs were nasal airway obstruction, facial swelling and nasal discharge, often occurring in combination. Radiographic changes were recorded in all horses. Sinus opacification was a consistent finding and in several cases the bone surrounding the sinus had increased in thickness. Increase in intra-maxillary sinus pressure was demonstrated by septal displacement on ventro-dorsal radiographs in almost half the cases. Less common signs included expansion, free fluid accumulation within the affected sinus, dental distortion and displacement and mineralisation. Two horses were destroyed without treatment but in 13 animals surgical exploration was performed. Two of these were destroyed, one at the time of surgery and one five days postoperatively. In the remaining 11 cases, all accessible parts of the cyst were removed through a facial flap and drainage to the nasal meati was established. All these horses recovered satisfactorily and were followed up for periods between three months and six years without evidence of recurrence. Thirteen cysts arose in the caudal maxillary sinus and one each in the frontal and rostral maxillary compartments. Histopathological examination of portions of the cyst walls suggests that, like ethmoidal haematomas, they may originate from episodes of haemorrhage beneath the upper respiratory tract mucosa.

Airway Obstruction↗

Pharmacokinetics of intravenously administered ketamine in the horse.

The metabolism and distribution of ketamine and its two major metabolites (norketamine and dehydronorketamine) was investigated in 10 horses undergoing airway surgery. Following premedication with xylazine (1.1 mg kg-1 intravenously) anaesthesia was induced by the rapid injection of ketamine at a dose of 2.2 mg kg-1 intravenously. Anaesthesia was maintained with halothane vaporized in oxygen and nitrous oxide (50:50). Serially collected blood samples were analysed by a sensitive gas liquid chromatographic technique. Plasma ketamine concentrations declined biexponentially with a rapid initial distribution phase (t1/2 2.89 +/- 0.25 minutes) being followed by a slower elimination phase (t1/2 65.84 +/- 3.46 minutes). Norketamine was found in the plasma of all the horses, but only at low concentrations while there was very little dehydronorketamine detected. It seems that recovery from ketamine anaesthesia in the horse depends mainly on rapid redistribution of the drug from the central compartment and this explains the abrupt recovery from ketamine anaesthesia often observed in the horse.

Anesthesia, General↗

Parasitic laryngeal papillomatosis in a horse.

Papillomatous lesions intruding into the laryngeal airway were identified in an imported polo pony during a routine neurological examination for partial quadriplegia. Histological examination established a diagnosis of laryngeal besnoitiosis but it is unlikely that the laryngeal parasitism was associated with the cerebellar neuropathy which was also present.

Animals↗

Cardiovascular instability following acute cervical spinal cord trauma.

Irregularities in vital sign (pulse, blood pressure, cardiac rhythm) recordings are commonly observed following acute spinal cord injury. These abnormalities have been generally attributed to autonomic instability. However, there have been no clinical reports that evaluate these problems in a large group of acutely injured patients. Therefore, this study was performed on 45 patients with acute cervical spinal cord injuries to evaluate the incidence, severity, and risk factors for cardiovascular instability. This investigation revealed that there is a direct correlation between the severity of the cord injury and the incidence and severity of cardiovascular problems. Endotracheal suctioning with or without documented hypoxia are major causes of severe bradycardia and cardiac arrest within the first 2 weeks after trauma. Careful monitoring of severely injured patients and attention to the warning signs of cardiovascular instability can reduce the risk of life-threatening emergencies.

Acute Disease↗

Clinicopathological features of lymphosarcoma involving the thoracic cavity in the horse.

The clinical and post mortem features of 11 cases of lymphosarcoma involving the thoracic cavity are reviewed. The clinical findings included inappetence, weight loss, pectoral oedema, dyspnoea, pleural effusion and distension of the jugular veins. Dysphagia was present in three cases. At post mortem examination lesions were found in the abdomen as well as the chest in eight cases; clinical signs of abdominal disease were present in two cases. The features of nine other similar cases recorded in the literature are reviewed.

Animals↗

Evaluation of an enzyme-linked immunosorbent assay (ELISA) for the diagnosis of Aspergillus fumigatus intranasal infection of the dog.

ELISA appears to be a less reliable method than counterimmunoelectrophoresis for the diagnosis of nasal aspergillosis in the dog. False-positive or false-negative results were recorded for anti-A. fumigatus IgG in nine animals with aspergillosis and in 27 disease-free dogs although this problem could be reduced with careful selection of antigen.

Animals↗