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Biomedical subjects

J G Chi

Publications and source records attributed to J G Chi.

At least 199 records · Page 11Linked to original sources
PubMed1989

Aneurysmal ("angiomatoid") fibrous histiocytoma in a child.

A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorder, such as the involvement of subcutis, its occurrence in the scalp, and a documented history of minor trauma. The lesion clinically resembled the gross features of hemangioma. The experience in the present case raises the need for considering AFH as one of major differential diagnosis of nodular cutaneous tumors in children that simulate malignancy such as angiomatoid malignant fibrous histiocytoma and Kaposi's sarcoma.

Child↗
PubMed1989

Acardiac twins--an analysis of 10 cases.

The pathological characteristics of the acardiac fetus were studied based on 10 autopsy cases. These cases were collected during a 13-year period at Seoul National University Hospital. All 10 fetuses were monochorionic twins, and six of them were male. Externally normal co-twins survived in five cases and died perinatally in three cases. The gestational period of these acardiacs ranged from 20 to 33 weeks. All of them showed a growth arrest of a fairly wide spectrum. Four cases belonged to acardius anceps, five were acardius acephalus, and one was acardius amorphus. Nine out of 10 cases were holoacardius, whereas one was hemiacardius with a vestigial heart tube present. Characteristic artery-to-artery anastomoses were demonstrated in all cases where examination was possible. The umbilical cords of the acardiacs often consisted of only two vessels, i.e., one umbilical artery and one umbilical vein, and these vessels were directly attached to the arteries and veins of the normal co-twins on the placental surface. The vascular system of the acardiac fetuses was simplified, providing only inflow and outflow pathways through common iliac vessels and vitelline vessels. When the head part was preserved (acardius anceps), the facial features were indistinguishable, particularly in the midfacial region, which resulted in a characteristic holoprosencephalic malformation of the brain in two out of four cases. Normal eyeball structure was not noted in any of these cases. The oral cavity and tongue were rarely recognized. Once the head part was absent (acardius acephalus) there was a wide variation of thoracic organ development. Hypoplastic lungs were seen in three cases, and they were connected to the trachea. A tracheoesophageal fistula was seen twice. The gastrointestinal tract was the most common feature of these acardiac monsters. However, it often lacked some portions, such as a stomach, midgut or part of a large intestine. The kidneys, testes and other parts of the urinary system were other common constituents of the acardiacs.

Abnormalities, Severe Teratoid↗
PubMed1988

Malignant tumors among Koreans-relative frequency study on 19,140 cases during 1978 to 1986.

A statistical analysis was made on 19,140 primary malignant tumors histopathologically diagnosed at Seoul National University Hospital during 9 year period from 1978 to 1986. The study was performed to understand the recent trend of the relative frequency of the primary malignant tumors among Koreans and to compare it with the previous studies using same hospital materials, twice presented in 1968 and 1978, respectively. Sex distribution of the cases was 10,025 (52.38%) males and 9,115 (47.62%) females. Among males the frequency rank was stomach (33.88%), lung and bronchus (8.73%), leukemia (7.02%), liver (4.79%) and oral cavity (4.70%). And among females it was uterine cervix (24.48%), stomach (20.45%), thyroid (7.87%), breast (6.48%) and leukemia (4.78%). The relative frequency of malignant tumors in this study was generally similar to the previous data published in 1978 at this department, except for the fact that stomach and lung cancers were more commonly seen in both sexes during this study period than the previous periods of years.

Cohort Studies↗
PubMed1988

Cross-sectional illustration on major types of conjoined twins.

Conjoined twins show varying degree of conjoining in either facing or side-by-side fashion. Cephalothoracopagus janiceps is a prototype of facing anomaly in which the two bodies demonstrated a cross symmetry to the midline, that is axial symmetry. Interfacial and intersternal lines crossed at a right angle and no abnormality of situs was associated. Dicephalus dipus dibrachius is a case of side-by-side union, in which the bodies facing nearly the same direction were symmetrical to the middle sagittal plane. Abnormal situs of one was always associated. Other types of conjoined twins as thoracopagus lie between the two extremes of facing and side-by-side union. The three dimensional architectures of the organs in each type would be explained using cross sectional figures of skull, thorax and pelvis. Although the facing twins share the internal organs without fusion, the organs in the side-by-side component are fused with modification of the situs. We postulate sixteen pairs of situs and four manners of division for the explanation of the midline organs and the presence of a dominant co-twin. The splenic locations in a given cardiopulmonary situs are evaluated for the appraisal and applicability of these hypotheses.

Embryonic and Fetal Development↗
PubMed1988

Primary intimal fibroplasia of the renal artery.

Two cases of primary intimal fibroplasia of the renal artery with renovascular hypertension are described. Case 1 was 27 year old female who was incidentally found to have blood pressure of 210/130 mmHg on routine physical examination. Renal arteriogram revealed tubular narrowing of the mid protion of the left renal artery. Both patients showed lateralization in renin activity at the involved side renal vein. Case 2 was a 10 year old girl who was first noted to have a hypertension of 180/120mmHg after a sudden attack of seizure, vomiting and altered consciousness. Renal arteriogram showed concentric narrowing of the proximal half of the right renal artery. Histopathologic examination of the affected arterial segments from both cases showed essentially same findings, i,e., diffuse fibrous thickening of the intima occluding the lumen, focal fragmentation, duplication and disappearance of the internal elastic membranes. There were no deposit of lipid and inflammatory cells. The media and adventitia remained intact. The blood pressure of both patients became normal, after the surgery and the patients are in good health up to this time.

Adult↗
PubMed1988

Congenital absence of ductus arteriosus--an autopsy case.

Isolated absence of the ductus arteriosus is extremely rare condition although the ductus arteriosus may be hypoplastic or aplastic in association with other aortic arch anomalies. Authors described a case of isolated agenesis of the ductus arteriosus documented by postmortem examination of a newborn infant who died of pneumonia following operation for a large omphalocele. The heart showed ventricular septal defect. However, no other cardiovascular anomalies were associated in this case. There were three vessels that were taking off from the aorta consisted of the right brachiocephalic artery, left common carotid-artery and left subclavian artery. The anteriorly located pulmonary artery was divided into the right and left pulmonary arteries. There was no connection of vessel between the pulmonary artery and the aorta.

Abnormalities, Multiple↗
PubMed1988

Tissue parasitic diseases in Korea.

Parasitic disease is still important subject in the field of infectious diseases in Korea considering it's number and morbidity. Recently there was conspicuous reduction of parasitic disease in terms of soil-transmitted nematodiasis, but parasitism affecting organs other than intestinal tract is still a considerable problem. This survey covers the parasitic diseases cross-sectioned at a pathology laboratory of a referral hospital, trying to elucidate the significance of its relative frequency and also to describe some histopathological changes made by different parasites. Entire pathological materials of parasitic diseases, that were referred, examined and confirmed at the Department of Pathology, Seoul National University Hospital from 1968 to 1987, were used for the study. There was a total of 594 cases of tissue parasitic diseases. This number accounted for 0.33 per cent of total accessions of surgical pathology. There occurred average 30 cases of tissue parasitic disease each year at this Hospital. Protozoal diseases were constituted of 15 cases of amebiasis, 7 cases of leishmaniasis (imported) and 5 cases of Pneumocystis carinii infections. Among helminthic infections cysticercosis was the most common (425 cases), and was followed by paragonimiasis (35 cases), sparganosis (31 cases), clonorchiasis (32 cases) and ascariasis (16 cases). In addition there were 4 cases of anisakiasis, 2 cases of fascioliasis, 2 cases of echinococcosis (imported) and a case of strongyloidiasis and a case of metagonimiasis respectively. It is emphasized that imported parasitic diseases such as leishmaniasis and hydatid disease become steadily found nowadays. Schistosomiasis is another possible imported disease, but not found in this series. And certain cestodiasis particularly cysticercosis and sparganosis should be the subjects of epidemiologic re-evaluation in view of steady occurrence of their morbidity.

Adult↗
PubMed1988

Malignant histiocytosis. Clinicopathologic review of 18 cases with immunohistochemical study.

We reviewed clinical and pathologic characteristics of 18 cases of malignant histiocytosis including 2 autopsy cases with special interest on their immunohistochemical characteristics. We report 3 cases of unusual immunohistochemical finding and postulate these cases may be a supportive evidence of the view that dendritic cells share common precursor with those of mononuclear phagocytic system. More accumulated cases in the future and careful analysis would be needed to answer the basic question about the origin of malignant histiocytosis.

Adolescent↗
PubMed1988

A case of unilocular hydatid disease imported from Saudi Arabia.

A 39-year-old Korean man with general malaise was found to have two hepatic cysts by computed tomography. He had the history of close contact with domesticated wild dog in Saudi Arabia in 1976. Two cysts, 15cm and 10cm in diameter which contained clear fluid, were excised from both lobes of the liver. He was pathologically diagnosed as unilocular hydatid disease. This case is regarded as an imported case from Saudi Arabia.

Adult↗
PubMed1988

A study on demyelinating effect of galactocerebroside in experimental allergic encephalomyelitis.

An experimental allergic encephalomyelitis was induced by bovine myelin basic protein (MBP) and bovine galactocerebroside (GC) on male guinea pigs. Animals were divided into five experimental and one control groups. Among the five experimental groups, three were inoculated with 75 micrograms, 150 micrograms and 300 micrograms of MBP, respectively, to see the dose dependency of demyelination. The fourth group was inoculated with mixture of 75 micrograms of MBP and 180 micrograms of GC and the fifth group with 180 micrograms GC. All inocula was injected intradermally in emulsion state mixed with equal amount of complete Freund adjuvant. Control group was injected with adjuvant only. Clinical symptoms began to appear from 15th day after inoculation and animals were sacrificed on maximum neurologic deficit or 4 to 5 days after the onset of symptoms. Demyelination was observed in 6 out of 8 animals inoculated with MBP/GC mixture, while only 3 out of 24 animals inoculated with various dosage of MBP showed demyelination. The difference was statistically significant. Serum antibodies to MBP and GC were measured by ELISA method. All of the eight animals inoculated with MBP/GC mixture and two animals inoculated with GC had low titer of anti-GC antibodies, while all animals inoculated with MBP, MBP alone or MBP/GC mixture, had high titer of anti-MBP antibodies. Therefor it is concluded that the demyelination is augmented by GC and is not significantly dose-dependent on MBP.

Animals↗
PubMed1988

Intestinal pathology in human metagonimiasis with ultrastructural observations of parasites.

A human case of intestinal metagonimiasis that was incidentally found during the histological examination of a resected segment of jejunum was described. The small adults trematode of Metagonimus yokogawai were found free in jejunal lumen as well as impacted in intervillous spaces. Histologically intestinal lesions were massive lymphoplasmacytic and eosinophilic infiltration in stroma, erosion of neanby enterocytes, goblet cell depletion and occasional villous edema. Scanning electron microscopy revealed the worm of spatulate appearance with rake-shaped tegumental spines. By transmission electron microscopy, the syncytial integument with dense discoidal bodies, basement membrane muscle cells and subtegumental cells were observed. Characteristic junctional complex was demonstrated between subtegumental and parenchymal cells as well as between parenchymal cells.

Adult↗
PubMed1988

A histopathologic study on 1,095 surgically resected thyroid specimens.

A histopathologic study was made on 1,095 thyroid specimens which had been removed surgically under various diagnoses at Seoul National University Hospital during the six-year period, 1976-1981. Among the 1,095 surgically removed thyroids, adenomatous goiter was the most common single disease, accounting for 43% of all cases; this was followed by papillary carcinoma and follicular adenoma. Of the malignant tumors, papillary carcinoma was the most frequent, accounting for 259 cases, 76.85% of all malignancies. Ground glass nuclei and psammoma bodies were seen in approximately 64% and 65% of the papillary carcinomas, respectively. Squamous metaplasia was, however, present in 17%. There were also 53 follicular, 13 anaplastic and seven medullary carcinomas. Of the 56 occult sclerosing carcinomas, most were detected in the backgrounds of the adenomatous goiters. Occult sclerosing carcinoma was found in 9.2% of the adenomatous goiters and in 4.3% of the follicular adenomas.

Adult↗
PubMed1987

Cerebral sparganosis: CT characteristics.

Cerebral sparganosis is an extremely rare parasitic zoonosis caused by a migrating plerocercoid tapeworm larva, genus Spirometra. Nineteen computed tomography (CT) scans of 12 patients with cerebral sparganosis were retrospectively analyzed and correlated with clinical and pathologic data. On CT scans, the following characteristics were noted: (a) unilateral involvement; (b) extensive or multifocal areas of low density along white matter bundles, with ipsilateral ventricular dilatation and localized cortical atrophy; (c) nodular or irregular enhancement with spotty calcification; and (d) change in location of enhancing nodules on sequential scans. These pathognomonic features reflect a chronic inflammatory process with both active granulomatous lesions and widespread degeneration of brain tissue, especially in the white matter. Degeneration is probably caused by migration of the long-surviving larva along the fiber tracts of white matter.

Adult↗
PubMed1987

Menkes disease--an autopsy case with metal analysis of hair.

We report the first case of Menkes' disease in Korea, occurring in a 1 1/2 year old boy with characteristic clinical, arteriographic and pathologic features. Postmortem examination revealed widespread neuronal destruction and abnormally tortuous and elongated large arteries including cerebral, visceral and limb vessels. Microscopically, many of the hairs formed were twisted (pili torti), of varying caliber (monilethrix), and fractured (trichorrhexis nodosa). In the radioactivated analysis of scalp hair, copper elements was not found. The abnormal vessels were characterized by fragmentation and disruption of the internal elastic lamina with intimal proliferation. The neuronal destruction was widespread in the cerebral gray matter and in the cerebellum, and there was associated gliosis. The changes in the cerebellum were particularly severe, with neuronal loss in the internal granular cell layer. Many Purkinje cells were lost, and the remainder showed unusual dendritic sprouts from the cell body and grotesque proliferation of dendritic tree. In other organs, mild chronic peribronchitis, and scattered foci of immature glomeruli in renal cortex were noted.

Angiography↗
PubMed1987

Disseminated neonatal herpes simplex virus infection with necrotizing encephalitis--an autopsy case.

An autopsy case of disseminated HSV type 2 infection occurring in a neonate at 32 weeks' gestation, delivered by cesarean section after premature rupture of membrane of 7 days duration, is presented. Herpes simplex virus type 2 was isolated from the vesicular skin lesion. The mother and patient had specific antibody to type 2 herpes simplex virus. Patient's parents had denied any herpetic orolabial or genital lesion during or before this pregnancy. Cultures from the cervical and vaginal swabs of the mother were negative for HSV. Postmortem examination showed hepatic necrosis, skin vesicle, devastating necrotizing inflammation of the brain, chorioretinitis and interstitial pneumonitis.

Autopsy↗
PubMed1987

Intestinal Behçet's disease in a child--a case report.

Behçet disease is relatively rare in pediatric age group. And the bowel involvement is seen in only a small portion of Behçet disease. However, once the bowel is involved it is potentially life threatening event. We report a 15 year old boy with intestinal Behçet's disease who had a history of recurrent oral and genital ulcers for several years. He underwent right hemicolectomy under the impression of intestinal tumor. Pathologically the lesion was a large sharply delineated ulcer in the cecum. The ulcer was round and deep with elevating margin, and was associated with thickening of affected intestinal wall. Microscopically, the ulcer base consisted of granulation tissue with fissurings and underminings. Characteristic phlebitis and occlusive arterial lesion were seen in intestinal wall. The inflammatory lesion was most pronounced around the ulcer but could be recognizable throughout the resected specimen.

Adolescent↗