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Biomedical subjects

J G Chi

Publications and source records attributed to J G Chi.

At least 217 records · Page 12Linked to original sources
PubMed1987

Crohn's disease--a case report.

A case of rather typical Crohn's disease in a 10 year old girl is described. She had suffered from intractable abdominal pain, diarrhea and fever for 1 year. Eventual right hemicolectomy revealed diffuse involvement of terminal ileum, cecum and ascending colon by confluent ulcerations and transmural inflammation. Histologically there were numerous well developed non-caseating granulomas scattered transmurally and in regional lymph nodes. Deep penetrating ulcerations were characteristic. Acid fast staining failed to demonstrate any organism. The rarity of Crohn's disease in Korea and this occurrence in pediatric age prompted this report.

Child↗
PubMed1987

Intramural sparganosis manifested as intestinal obstruction--a case report.

A case of intramural sparganosis of jejunum presenting as intestinal obstruction is described. Resected intestine from a 48 year old man with acute abdomen revealed a degenerated sparganum in the submucosa with typical tissue reaction and extensive edema. The tissue reaction was basically granulomatous, consisting of layers of inner palisading histiocytes and outer mononuclear cell infiltration. Many calcospherules were prominent within the degenerated worm. Eosinophil infiltration was scanty.

Granuloma↗
PubMed1987

Intracranial granulocytic sarcoma (chloroma) in a nonleukemic patient.

Chloroma is a granulocytic sarcoma with it's characteristic greenish color. Recently there is an increased number of cases that are apparently aleukemic when the tumor mass is first presented. Recently we experienced a case of granulocytic sarcoma with characteristic green color (chloroma), which showed no evidence of leukemia in the bone marrow and peripheral blood. This patient presented headache, and was diagnosed brain tumor on computed tomography. A left parietal cranietomy was done to remove a large central dome-like mass, 8 cm, involving the dura with a slightly dusky greenish solid appearance. Compact nests of moderately mature granulocytes and immature cells comprised the tumor. Histochemical and electron microscopic studies confirmed these tumor cells as myeloid cells in varying stages of maturation. Several days after the operation, left cervical lymph nodes became palpated, and the biopsied lymph nodes revealed same neoplastic cells seen in the skull. However, bone marrow aspiration, biopsy and peripheral blood smears did not show any evidence of leukemia.

Adolescent↗
PubMed1987

Liver cell adenoma in a neonate--report of an autopsy case.

A case of liver cell adenoma that was incidentally found at postmortem examination of a neonate who died of E. coli sepsis is described. The adenoma was a sharply demarcated, not encapsulated mass located subcapsularly in the right lobe, and was pale tan to light yellowish round nodule of 0.9 cm in diameter. Microscopically, the tumor was composed of sheets and cords of uniform and slightly enlarged hepatocytes separated by dilated sinusoids. There were no portal zones or central veins to suggest the normal lobular architecture. The nuclei were bland and the cytoplasm varied from clear to acidophilic, containing lipid vacuoles. Ultrastructural examination showed that the hepatocytes of the tumor had highly differentiated organelles, reminiscent of normal hepatocytes.

Adenoma↗
PubMed1987

Infantile hemangioendothelioma of the liver--a case report.

A case of type 1 infantile hemangioendothelioma of the liver in a 3 month old male infant who had an abdominal mass incidentally noted at 40 days of age, is described. Grossly, the tumor showed a well circumscribed, pinkish gray and gelatinous mass with areas of central necrosis, multifocal thrombi and hemorrhages, and small cysts. Microscopically, the lesion consisted of numerous vascular channels of various size lined by a single layer of flat or plump endothelial cells. Areas of infarction, thrombosis and calcification, and formation of cavernous hemangiomatous foci were also noted in the lesion. Ultrastructurally, the cells had the characteristics of endothelium, including basal lamina, pinocytic vesicles, and Weibel-Palade bodies. Factor VIII-associated antigen was demonstrated in the tumor cells.

Hemangioendothelioma↗
PubMed1987

Malignant lymphomas in Korea.

A retrospective histological study of 540 malignant lymphomas diagnosed at the Department of Pathology of the Seoul National University from 1976 through 1986 is presented. Malignant lymphoma is the 10th most common malignant tumor in Korea, comprising 3.07% of all malignancy during period of study. Among malignant lymphomas non-Hodgkin's lymphoma accounted for 82% and accordingly the Hodgkin's disease was for 18%. The most common type of non-Hodgkin's lymphoma was diffuse histiocytic lymphoma of Rappaport. Follicular lymphoma was very rare, comprising only 2.3%. T-cell lymphoma accounted for 9.6% of non-Hodgkin's lymphomas, the most frequent type being lymphoblastic lymphoma. Immunoblastic sarcoma and mycosis fungoides were occasionally seen but there was no case of pleomorphic adult T-cell lymphoma. Among Hodgkin's diseases, mixed cellularity type was the most common type, and nodular sclerosis type was relatively rare.

Adolescent↗
PubMed1987

An evaluation of frozen section biopsy in 4434 cases.

Frozen section diagnosis is a highly useful method of diagnosis. There were 4434 frozen sections, 24 false positive diagnosis, 65 false negative diagnosis and 30 deferred diagnosis. This method achieves the highest accuracy when there is a cooperation between experienced surgeon and reliable and careful pathologist. It is wise to defer the diagnosis of consult to other pathologist in difficult situation.

Biopsy↗
PubMed1986

Ovarian sex cord tumor with annular tubules.

A pathologic study was done on four cases of ovarian sex cord tumor with annular tubules. All four tumors occurred in young women (11-24 years of age) and were not associated with the Peutz-Jeghers syndrome. Two patients had evidence of hyperestrinism. One patient who had metastasis to the retroperitoneum, left supraclavicular lymph node, and liver confirmed the malignant potential of this tumor. Gross examination revealed tumors that were solid, yellowish, and unilateral, with varying degrees of cystic degeneration. Microscopic examination showed simple or complex annular tubules with prominent basement membranes. Many tumor cells contained lipid in the cytoplasm. Ultrastructural study showed Charcot-Bottcher filaments in all four cases, indicating Sertoli cell differentiation. True lumens and microvilli were identified in one case. The classification of the sex cord tumor with annular tubules as a Sertoli cell tumor, annular tubular type was proposed on the basis of ultrastructural findings.

Adolescent↗
PubMed1986

Melanotic neuroectodermal tumor of infancy.

A case of melanotic neuroectodermal tumor of infancy was presented. This tumor occurred in the right maxillary alveolar ridge of 3-month-old female infant, showing bluish enlargement of alveolar mucosa with the displacement of central deciduous incisor. We described the gross, microscopic, and ultrastructural findings of this tumor. This case appears to be the first case of MNTI, reported in a Korean.

Female↗
PubMed1985

Cardiovascular system in conjoined twins: an analysis of 14 Korean cases.

A new classification of cardiovascular system in conjoined twins is introduced. A special effort has been made to analyze the degree of fusion and symmetry of hearts and great vessels, based on 14 pairs of conjoined twins. The degree of cardiovascular union of the twins is classified into five types. Cases with no vascular union in cardiac, aortic, and inferior vena caval levels were grouped into type I (four cases). Cases with separate hearts and union between aortas or inferior venae cavae were grouped into type II (three cases). Cardiac fusion at the atrial level was grouped into type III (three cases). All of the three cases showed fusion between right atria (subtype IIIa). The theoretical fusion between the left atria or between the left and right atria is put into subtype IIIb. The type IV represents fusion of both atria and ventricles regardless of the number of the chambers (three cases). Type V represents single heart in one of the twins (one case). The external morphologic type and the situs of each twin pair were closely related to the cardiac abnormalities. Dicephalus and thoracopagus were more likely to be associated with abnormal situs and complex cardiac fusion. Abnormal situs was seen in seven out of 14 cases. Three cases with polysplenia and a case with asplenia showed more complex cardiac abnormalities than those with normal situs or situs inversus.

Cardiovascular Abnormalities↗
PubMed1985

Malignant lymphomas in Korea.

A retrospective histological study based on biopsy material of 341 cases of malignant lymphoma diagnosed at the Department of Pathology of the Seoul National University from 1976 through 1983 was conducted, to reveal some characteristics of malignant lymphomas occurring in Korea. Malignant lymphoma was the seventh most common malignant tumor (4.03%) among Koreans. Non-Hodgkin's lymphoma predominated over Hodgkin's disease, accounting for 87% of all malignant lymphomas. Follicular lymphoma was rarely seen in Korea (3%), and among types of non-Hodgkin's lymphoma the diffuse histiocytic type (57%) and the poorly differentiated lymphocytic type (26%) of Rappaport were common. Follicular center cell lymphomas (Lukes-Collins) were most commonly seen, whereas T-cell lymphoma was found in approximately 10% of the non-Hodgkin's lymphomas. Not a single case of pleomorphic adult T-cell lymphoma was encountered in this series. Among subtypes of Hodgkin's disease the nodular sclerosis type was particularly rare, comprising only 15% of the Hodgkin's disease cases.

Adolescent↗
PubMed1984

Fetus-in-fetu: report of a case.

A case of fetus-in- fetu is reported. It occurred in an 8-week-old Korean boy who had been born by cesarean section due to abdominal distension. The fetus-in- fetu was connected to the superior mesenteric artery and consisted of two masses, apparently representing two portions of an acardiac monster. There was an amniotic membrane covering both masses, and the umbilical cord clearly was identifiable. One mass included the brain, eye, trachea, salivary glands, thyroid, pancreas, spleen, etc., while the other mass contained extremity bones, vertebrae, testis, adrenals, and intestinal loops. This is probably a case of separated fetus-in- fetu that showed unusually well-developed internal organs.

Abnormalities, Severe Teratoid↗
PubMed1982

Diffuse striated muscle heteroplasia of the lung. An autopsy case.

We studied a diffuse, striated muscle heteroplasia in the lungs in a 20-week-old stillborn fetus. The lung was small, but retained normal shape. There was no tumefaction. Histologically, a massive and diffuse distribution of the striated muscle cells was found among the interstitia of the dysplastic lung, representing solid adenomatoid malformation. Based on the findings in this case and the cases of others, we believe that the presence of the striated muscle and adenomatoid malformation are causally related, and the striated muscle cells arise from the heteroplastic transformation of the pluripotential embryonal mesenchymal cells.

Female↗
PubMed1981

Leigh's subacute necrotizing encephalomyelopathy: possible diagnosis by CT scan.

A 28-month-old Korean girl developed a rapidly progressive disease, characterized by disturbance of consciousness, tremor, nystagmus, ophthalmoplegia, irregular deep respiration and vomiting. The patient succumbed 2 weeks after the onset of the illness. CT scan disclosed bilaterally symmetrical, low density lesions in the white matter and lateral basal ganglia. Distinctive histopathological findings at postmortem included spongiotic necrosis of the neuropil, marked capillary vascularity, persistence of relatively normal neurons in severely damaged zones, and comparatively little astrocytosis. The bilaterally symmetrical distribution of these changes in the putamen and periaqueductal gray matter of the midbrain were compatible with Leigh's disease.

Central Nervous System Diseases↗
PubMed1980

Anatomical observations of the development of the pituitary capsule.

A morphological study on the development of the pituitary capsule is reported, based on serial or step-sections of 56 pituitary glands from human embryos and fetuses ranging in gestational age from 4 to 40 weeks. Formation of the pituitary capsule is preceded at a very early embryonic stage by mesenchymal cell proliferation around Rathke's pouch when it forms the primitive adenohypophysis. The proportionally large adenohypophysis wraps around the neurohypophysis as it grows down from the diencephalon. Therefore, the fibrous capsule around the adenohypophysis represents the whole hypophysis as a membrane district from the dura mater or pia arachnoid membrane. The pituitary capsule appears not be to a derivative of either the dura mater or the pia arachnoid; instead it is a separate covering of the developing Rathke's pouch.

Anencephaly↗
PubMed1977

Left-right asymmetries of the temporal speech areas of the human fetus.

Left-right asymmetries of the transverse temporal (Heschl) gyri and the temporal plane become recognizable by 31 weeks' gestation. The transverse temporal gyri are larger in number and extent on the right side in 54% of 207 serially sectioned fetal brains ranging in gestational age from 10 to 44 weeks, and the temporal plane is larger on the left side in those brains. There are two transverse temporal gyri on the left and a single right transverse temporal gyrus on the right in 18% of the brains. No asymmetry of number of transverse temporal gyri or extent of the temporal plane is apparent in 28%. These findings, which confirm those in adult brains, suggest that anatomical asymmetries for left hemispheral speech and language dominance may be established during the last trimester of fetal life.

Female↗
PubMed1977

Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland.

Striking similarities between the pineals of 107 fetuses and infants and a pigmented neuroectodermal tumor occurring in the right orbital and right frontal regions in a 6-month-old Puerto Rican boy were found. Both the human fetal pineal and melanotic neuroectodermal tumors of infancy are characterized by pigmented (melanin) epithelial cells, small undifferentiated cells, and a fibrovascular stroma. Our findings suggest the fetal pineal may be a normally occurring precursor of the melanotic neuroectodermal tumor of infancy, or that melanin production may be a normal capability of differentiating neuroepithelial cells.

Child, Preschool↗