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Biomedical subjects

J Flament

Publications and source records attributed to J Flament.

At least 73 records · Page 4Linked to original sources
PubMed1987

[The visual field of pseudophakic patients. Perimetric and statistical study].

One hundred and twenty two visual fields were studied in 98 pseudophakic subjects, using cinetic perimetry according to Goldmann, in order to plot the internal (I1), medium (I2) and peripheral (I4) isopters. Computerized processing of data provided average results, allowing the following conclusions: In general, 20% of the total surface is lost in pseudophakia. This loss, as a consequence of prismatic effects of lenses, involves the internal isopters (26%) rather than the peripheral isopters (15%). Individually, these data can be modified by the location of the lens or by the diameter of its optical part: the more anterior or the smaller is the optical part, the narrower does the visual field become. Additional correction, particularly if exceeding 2 diopters is a supplementary factor of reduction. The perimetric consequences of pseudophakia are functionally latent. Nevertheless, the prismatic effects of intraocular lenses could account for the difficulties met in examination of peripheral fundus.

Adolescent↗
PubMed1986

Treatment of hairy-cell leukemia with recombinant alpha 2-interferon.

Eleven patients with hairy-cell leukemia (eight with progressive and three with non-progressive disease) were treated with low dose recombinant human alpha 2-interferon. After a 3-month treatment period, nine patients showed an improvement and one patient a partial remission. By then, transfusions were not required any more and serious infections were no longer encountered. Four patients were further treated: three for a total period of 9 months and one for 6 months; all of them reached a partial or complete remission. The treatment was equally effective in patients with both progressive and non-progressive disease. Previous absence of response to splenectomy did not preclude a positive effect of IFN therapy. In two patients, IFN dose reduction was necessary due to unremitting flu-like symptoms.

Humans↗
PubMed1986

[Course and prognosis of serous detachment of the retinal pigment epithelium].

In a 15-year retrospective study the spontaneous evolution of serous detachment of the pigment epithelium was investigated functionally, by perimetry, biomicroscopically, and angiofluorographically, in order to identify the manifestations of this syndrome and determine its prognosis. Serous detachments of the retinal pigment epithelium are generally associated with senile macular degeneration, central serous chorioretinopathy, diffuse pigment epitheliopathy, or are idiopathic. The patients studied were divided into two groups: 45 patients under 55 years old (64 eyes), kept under observation for an average of 70 months, and 42 patients over 55 years old kept under observation for an average of 38 months. These two groups were compared with a group of cases of isolated colloidal degeneration. The good prognosis for the first group is emphasized. Stabilization or improvement of visual acuity was normal. In the second group, complications included subretinal neovascularization in 29% and tears in the retinal pigment epithelium in 3.5% of the cases. Visual acuity deteriorated in one-third of the cases. Factors which adversely affected prognosis were an initial detachment larger than the diameter of the optic disk, macular location, and contralateral neovascularization. However, the results with spontaneous evolution were not worse than those in laser-treated cases reported in the literature.

Adult↗
PubMed1986

[Sarcoidosis of the anterior optic pathways. A diagnostic discussion].

Two anatomo-clinical cases of neuro-ophthalmic sarcoidosis are reported where recognition of systemic involvement was delayed because unusual and quite isolate visual symptoms were present. The first patient had granulomas involving the intracranial optic nerve, presenting as optic nerve glioma. The second case presented as a chiasmal syndrome sharing unusual perimetric evolution. This binasal hemianopsia was probably the consequence of pre-chiasmal circulatory changes. Neuro-ophthalmic sarcoidosis should be included in the differential diagnosis of any involvement of the anterior visual pathways since these localizations are not as rare as was formerly thought. Improved awareness of this condition is a result of better neurodiagnostic studies by computed tomography which was not accurate enough a few years ago.

Diagnosis, Differential↗
PubMed1986

Impairment of phagocyte oxidative metabolism in hemodialyzed patients with iron overload.

In order to study the influence of iron overload on the polymorphonuclear leucocyte (PMN) metabolism of patients on chronic hemodialysis, generation of superoxide anion (O2-) by PMN in whole blood was compared in two groups of hemodialyzed patients: group A consisted of twenty-one individuals with serum ferritin levels above 1000 ng/ml and group B of nineteen individuals with serum ferritin levels below 1000 ng/ml. Whereas basal production of O2- was similar in the two groups (6.3 +/- 4.6 vs 11.5 +/- 8.3 nmoles O2- 10(6) granulocytes-1 15 min-1) (mean +/- s.e.m.), PMN response to opsonized zymosan was significantly lower in group A as compared with group B (86.5 +/- 6.3 vs 120.4 +/- 8.2 nmoles O2- 10(6) granulocytes-1 15 min-1) (p less than 0.01). Superoxide anion generation induced by the dialysis procedure was reduced in eight patients from group A (89.2 +/- 32.1) as compared with eight patients from group B (374.3 +/- 100.0 nmoles O2- 10(6) granulocytes-1 15 min-1) (p less than 0.05). These data suggest that iron overload may be involved in the impairment of neutrophil phagocytosis in patients on chronic hemodialysis.

Blood Transfusion↗
PubMed1985

Therapeutic effect of human recombinant interferon-alpha-2C in essential thrombocythaemia.

Human recombinant interferon-alpha 2C was given to 4 patients with essential thrombocythaemia. Three patients achieved a complete remission on day 19 +/- 1 and the 4th achieved a partial remission. After 4 weeks of induction therapy, a maintenance therapy of twice weekly intramuscular injections of 5 X 10(6) or 10 X 10(6) IU was instituted but did not maintain the remission.

Aged↗